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FETAL GROWTH
RESTRICTION
DISCUSSION
Prof.Pushpalatha
ETIOLOGY OF FGR…….
Maternal
Hypertensive
disorders
Diabetic
vasculopathy
CRF
Collagen vascular
disease
Thrombophilia
Fetal
Aneuploidy
Viral infections
Heart Disease
Placental
Placental
abnormalities
Thrombosis
Chorioangioma
Placental
Dysfunction
CHROMOSOMAL
ABNORMALITIES…..
Edward’s
Patau’sDown’s
DIAGNOSIS……….?
Clinical
examination
Ultrasound
EXAMINATION
SFH
Sensitivity
60-85%
PPV
20-80%
ULTRASOUND
BIOMETRY…… A C
Highest
sensitivity
Highest NPV
Serial
measurement
Smallest
measurement
FETAL DOPPLER….
UMBLICAL ARTERY
FETAL DOPPLER….
Reduced diastolic
flow-30 % villi affected
Absent/reversal-70%
affected
Reduces fetal death
by 29%
Intervention
based on fetal
doppler
MCA
MCA
Hypoxia –
Cerebral Vasodilation
Brain Sparing / Cephalisation
 flow liver & kidneys, “Hind
limb reflex” Oligohydramnios
MCA
Does not predict more than umb A alone
-ve predictive value
Worsening of hypoxia – normalisation of
previously abn MCA doppler
MCA – PSV remains abnormal as fetus
decompensates
VENOUS DOPPLER
Ductus Venosus
•Forward flow throughout
cardiac cycle
•Reflects cardiac function
DUCTUS VENOSUS
VENOUS DOPPLER
Reversed ‘a’ wave backflow in venous
circulation leads to pulsations in umbilical vein &
reversed flow in IVC - foetal right heart faliure.
Associated with metabolic acidosis
Venous doppler evaluation most beneficial in
early onset IUGR
DOPPLER INDICES < PNM
Doppler
Parameter
Increased UA resistance
Absent UA EDF
Decreased MCA
Reversed UA EDF
IAUV Pulsations
Abnormal DV a-wave
Perinatal
Mortality
5.6%
11-13%
21%
20-24%
35%
30-38%
ANTEPARTUM SURVEILLANCE EARLY
N umblical
art
Uterine art.
notching Elevated
doppler
index
Brain
sparing
N MCA
N DV
N UV
DOPP
LER
FHR –delayed maturation
AFV – no changes
BPS – delayed maturation of
ANTEPARTUM SURVEILLANCE LATE
Umb art.
AREDF
DV elevated
index
Loss of
variability
Umb V- pulsatile
flow
Absent/rever
sed a wave
Late
deceleratio
n
oligohydram
nios
anhydramni
os
Declining
activity
Loss of tone
Loss of
movement
Loss of
breathing
DOPP
LER
AFV
FHR
BP
S
MANAGEMENT
Rest  stress, quit smoking
Low dose aspirin
Antenatal corticosteroids – word of
caution
Doppler waveform abn precede abn in
BPP & NST by several weeks
MANAGEMENT
Most
mature
foetus
HIE /
PM
BALANCE
MANAGEMENT
Abn UA
waveforms
Late decelaration
• Lagtime is more in
Preterm
• Less in term
GRIT TRIAL
500 Women
• Randomized
• A / R EDF in UA
• Immediate Vs Delayed Delivery
Outcome
• No difference in perinatal
mortality
• At 2 years no difference in
neurological outcome > 31
wks
GRIT TRIAL
< 31 wks immediate
delivery  in disability(14%
vs 5 %)
GA is the greatest
determinant of intact
survival
Awaiting TRUFFLE study
results
ALGORITHM
DECREASED EDF
NST Bi weekly
BPP weekly
UA doppler weekly
Fetal growth every 3 weeks
AREDF
Hospitalisation
Frequent / continuous fetal monitoring
Steroids
MCA doppler weekly
DV doppler every 3-4 days
BPP daily
FGR > 24 wks
UMBLICAL
ART DOPPLER
MODE OF DELIVERY
UA  EDF normal OCT
successful induction of
labour
A / RED EDF ----- LSCS
SCREENING
Ultrasound
Uterine
artery
notching
Biochemical
analytes
AFP
Beta HCG
PlGF
SCREENING UTERINE ARTERY
THANK YOU….

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Fgr case discussion