3. Gestational hypertension
new hypertension presenting after 20 weeks without
significant proteinuria and features of
preeclampsia,BP levels return to normal within 3
months postpartum
Pre-eclampsia
is new hypertension presenting after 20 weeks with
significant proteinuria.
Severe pre-eclampsia
is pre-eclampsia with severe hypertension and/or
with symptoms,and/or biochemical and/or
haematological impairment. after 20 weeks
4. Eclampsia is a convulsive condition associated
with pre-eclampsia
Chronic hypertension is hypertension that is
present before 20 weeks characterized by a BP
of 140/90 mmHg or greater . It can be primary
or secondary in aetiology
Pre-eclampsia superimposed on chronic
hypertension is hypertension present before 20
weeks with development of symptoms of pre-
eclampsia after 20 weeks
5. Significat proteinuria excretion of 300mg/24hr of
urinary proteins in 24hr urine collection or a
concentration of 30mg/dl >1+ on dipstick in atleast
two random urine samples collected 4 to 6 hrs apart
Grades of hypertension
Mild hypertension
diastolic blood pressure 90–99 mmHg, systolic blood
pressure140–149 mmHg.
Moderate hypertension
diastolic blood pressure 100–109 mmHg, systolic blood
pressure 150–159 mmHg.
Severe hypertension
diastolic blood pressure 110 mmHg or greater, systolic
bloodpressure 160 mmHg or greater
6. A pregnancy specific syndrome characterized by
variable degrees of placental dysfunction and a
maternal response featuring systemic infammation
7. The etiology of preeclampsia is unknown. However,
placental delivery reverses the symptoms of
preeclampsia, suggesting that the placenta has a
controlling role in the condition. Additionally, women
with increased placental tissue for gestational age, such
as hydatiform moles and twin pregnancies, have an
increased incidence of preeclampsia.
Several theories attempt to explain the
pathophysiology of preeclampsia
Most popular theory holds that improper placental
development results in placental vascular endothelial
dysfunction and a relative uteroplacental insufficiency.
The vascular endothelial dysfunction results in
increased permeability, hypercoagulability, and diffuse
vasospasm
8. Changes in normal pregnancy
In normal pregnancy spiral arteries of the placental bed undergoes
a series of physiological changes
cytotrophoblasts replace the endothelial cells in the spiarl arteries
resulting in destruction of medial elastic and muscular tissue,these
physiological changes reach the inner third of myometrium and
create a low vascular arterioler system that allows a dramatic
increase in blood supply necessary to serve the growing fetus.The
end result is that 100 to 120 spiral arteries are converted into dilated
inelastic tubes without maternal vasomotor control
Changes in preeclampsia
In pre-eclampsia about half to 2/3rd of spiral arteries escape this
transformation ,in these arteries the myometrial segment remain
anatomically intact,do not dilate,many vessels are occluded by
fibrinoid material and exhibit adjacent foam cell invasion
(atherosis).Atherosis and thrombosis leads to microinfarcts in
placenta and are responsible for abruption due to decidual
necrosis,separation and hemmorhage.
9.
10.
11.
12. Cardiovuscular system
Severe pre-eclampsia is characterized by vasoconstriction and a leaky
microcirculation,with extravasation of fluid in E.C.S and relative hypovolemia
leading to hemoconcentration,edema and swelling often facial particularly
peroorbital edema in contrast to physiological pedal edema
Renal system
Primary renal manifestation of endothelial cell activation is inflammatory
swelling of glomeruler endothelial capillaries causing an increase in the renal
vascular resistance with a decrease in the renal blood flow resulting in decreased
GFR and EFRP complicating to ANURIA or OLIGURIA leading to ARF.
The first change in the renal system involvement is tubular dysfunction resulting
in decreased uric acid clearance from the body and hyperuicemia,the next event is
proteinuria due to loss of negative charge from the GBM ,finally there is rise in
levels of urea and creatinine . Proteinuria further leads to hypoalbunemia with
extravasation of fluid in ECS resulting in genearilzed edema and,ascites,pleural
effusion,pulmonary,cerebral and laryngeal edema.
13. Abnormal hemostasis
Platelet activation a feature of normal pregnancy is exaggerated in
pre-eclampsia as sysytemic endothelial cell activation cause platelet
adherence to site of endothelial damage.Platelets consumption
result in thrombocytopenia while platelet adherence leads to
formation of microthrombi effecting microcirculation leading to
increased intravuscuar coagulation with a rise in fibrin
degradation products and hemolysis of RBC’s in microvessels
leading to HELLP syndrome.
HELLP syndrome
It is Hemolysis,elevated liver enzymes and low platelets caused
by abnormal hemostasis and liver involvement due to excessive
fibrinogen deposition in hepatic sinusoids also obstructing blood
flow leading to hepatic capsular distension and epigastric
pain,nausea,vomiting. It may complicate to subcapsular
hematoma and liver rupture presenting with severe epigastric
pain,shoulder pain,shock, hemoperitoneum,respiratory difficulties
or pleural effusion.
14. Nulliparity
extremes of maternal age
multifetal gestation
pre-eclampsia in a previous pregnancy
family history
chronic hypertension or renal disease
chronic infections
maternal low birth weight
obesity and insulin resistance
Pre-gestational DM
smoking
maternal genes
chronic inflammatory conditions like (SLE & RA)
Anti-phospholipid antibody syndrome
molar pregnancy
15. Symptoms of pre-eclampsia
severe headache
problems with vision, such as blurring or flashing before the eyes
severe pain just below the ribs
vomiting
sudden swelling of the face, hands or feet.
Seizures (eclampsia) grand mal in character with tonic clonic phases
Physical signs:
Asymptomatic hypertension is discovered on routine prenatal
examination.
Diffuse edema has a high specificity for preeclampsia.
Neurologic findings such as papilledema and hyperreflexia must be
addressed quickly, as they can herald the onset of eclampsia.
Petechiae and bruising could suggest coagulopathy.
Right upper quadrant or mid epigastric tenderness develops as a
result of hepatocellular necrosis.
16. Complications
Maternal complications
Abruption placenta
DIC/HELLP syndrome
Acute Renal Failure
Eclampsia
Liver failure & Hemmorhage
Stroke
Death
Long term cardiovascular morbidity
Neonatal complications
Preterm delivery
IUGR
Hypoxic neurological injury
Perinatal death
Low birth weight with long term morbidity
18. BASELINE
•CBC
•BLOOD GROUP
•HEPATITUS B & C
Urine analysis of a clean catch specimen
Proteinuria 2+ or higher is significant and warrants further
evaluation to rule out preeclampsia.
A 24-hour urine collection with more than 300 mg of protein
RFT’s
• UREA > 40 mmol/l or >11 mg/dl
• Creatinine>1 mg/dl
• Serum uric acid levels >6.3 mg/dl
LFT’s
• AST or ALT >50 IU/L
• Biluribin >25 IU/L
Clotting profile
• PT/APTT
• Fibrin degradation products
19. Ultrasound
Confirmation of normal fetal development is important
and standard prenatal care in all pregnancies.Points to
study in US are
Fetal biometry(AC,HC,BPD,FL)
AOL & estimated fetal weight
Placental localization
Doppler velocimetry
Screening test in first trimester to detect changes in
spiral arteries and is considered abnormal if there is an
early diastolic notch or high RI
20. Management can be discussed under following headings
Prevention
Antihypertensive treatment
Anticonvulsant treatment
Steroids for lung maturation
Fluid balance
Mode and timing of birth
Fetal monitoring in high risk patient
Intrapartum care
Postnatal monitoring,treatment and investigations
Breast feeding
Advice and follow up care
21. Primary prevention
Pre pregnancy weight control in high risk patients
Vitamin B and folate supplementations
Cessation of smoking
Control of Hypertension in women having chronic hypertension
Control of sugar levels in women having Diabetes pre-pregnancy
Secondary prevention
Calcium supplementations:it reduces parathyroid and renin release
thereby reducing intracellular calcium and smooth muscle
contractility,the ideal patient is the one who is obese with raised BP at
booking visit
Antiplatelet agents:low dose aspirin is recommended in high risk
patients as it inhibits thromboaxane synthesis thus altering the balance in
favor of PGI usually before 23 weeks and therefore helps in proper
placentation in a dose of 75mg OD starting from 12 weeks until birth
For other agents like Mg and Zinc supplements,fish oil,salt restriction,
antioxidants like vitamin C,E there is insufficient data to recommend
their use in primary prevention
22. Degree of
hypertension
Mild hypertension
(140/90 to 149/
99 mmHg)
Moderate hypertension
(150/100 to 159/
109 mmHg
Severe hypertension
(160/110 mmHg or
higher)
Admit to hospital NO YES YES
Treat NO With oral labetalol† as
first-line treatment to
keep:
diastolic blood
pressure between
80–100 mmHg
systolic blood
pressure less than
150 mmHg
With oral labetalol† as
first-line treatment to
keep:
diastolic blood
pressure between
80–100 mmHg
systolic blood
pressure less than
150 mmHg
Measure
blood
pressure
At least four times a
day
At least four times a day More than four times a
day, depending on
clinical circumstances
Test for
proteinuria
Do not repeat
quantification of
proteinuria
Do not repeat
quantification of
proteinuria
Do not repeat
quantification of
proteinuria
Blood tests Monitor using the
following tests twice a
week: kidney function,
electrolytes, full blood
count, transaminases,
bilirubin
Monitor using the
following tests three
times a week: kidney
function, electrolytes, full
blood count,
transaminases, bilirubin
Monitor using the
following tests three
times a week: kidney
function, electrolytes, full
blood count,
transaminases, bilirubin
23. Only offer women with pre-eclampsia
antihypertensive treatment other than labetalol
after considering side-effect profiles for the
woman, fetus and newborn baby.
Alternatives include methyldopa† and
nifedipine†
24. Adult Dose 5-10 mg IV;
repeat 20min to maximum of 60
mg
Contraindications
Documented
hypersensitivity, dissecting
aortic aneurysm, mitral valve
rheumatic heart disease
Interactions:MAO inhibitors
and beta-blockers may
increase hydralazine toxicity;
pharmacological effects of
hydralazine may be
decreased by indomethacin
Adverse effects headache,
flushing, overshoot
hypotension, peripheral
edema, implicated in
myocardial infarction;
Pregnancy C (safety not
established)
Hydralazine (Apresoline) -- First-line therapy against preeclamptic
hypertension in past decades. Decreases systemic resistance through direct
vasodilation of arterioles resulting in reflex tachycardia..
25. Labetalol (Normodyne) -- Second-line therapy
that produces vasodilatation and decrease in systemic
vascular resistance. Has alpha-1 and beta antagonist
effects and beta-2 agonist effects. Has more rapid onset
than hydralazine and less overshoot hypotension.
Adult Dose 50-100 mg
IV; repeat 30min to a maximum of
300 mg
Preganacy C (safety not
established)
Contraindications
Documented
hypersensitivity,
cardiogenic shock,
pulmonary edema,
bradycardia, heart block,
uncompensated CHF,
reactive airway disease
Precautions Caution in
impaired hepatic function;
discontinue therapy if there are
signs of liver dysfunction; in
elderly patients, a lower
response rate and higher
incident of toxicity may be
observed; intensified
bronchospasms, heart block,
CHF
26.
27. Nifedipine
Potent direct vasodilators,rapid onset of action,safe and effective
Adverse effects severe headache,hypotension and flushing
Nitroprusside (Nitropress) -- Used when hydralazine and labetalol are
ineffective. Reduces peripheral resistance by acting directly on
arteriolar and venous smooth muscle.
Pregnancy C - Safety for use during pregnancy has not been
established.
adverse effects of nitroprusside include tinnitus, blurred vision,
altered mental status, hypotension, and methemoglobinemia
Diazoxide powerful direct vasodilator
mini-bolus dose of 15mg of diazoxide is as effective as hydralazine
with less side effects
28. When to use?
If a woman in a critical care setting who has severe
hypertension or severe pre-eclampsia has or
previously had an eclamptic fit, give intravenous
magnesium sulphate*.
Consider giving intravenous magnesium sulphate*
to women with severe preeclampsia who are in a
critical care setting if birth is planned within 24 hours
29. If considering magnesium sulphate* treatment, use the
following as features of severe pre-eclampsia:
severe hypertension and proteinuria or
mild or moderate hypertension and proteinuria with one or
more of the following:
1. symptoms of severe headache
2. problems with vision, such as blurring or flashing before the
eyes
3. severe pain just below the ribs or vomiting
4. papilloedema
5. signs of clonus (≥3 beats)
6. liver tenderness
7. HELLP syndrome
8. platelet count falling to below 100 x 109 per litre
9. abnormal liver enzymes (ALT or AST rising to above 70
iu/litre).
30. Use the Collaborative Eclampsia Trial[2]
regimen for administration of magnesium
sulphate*:
loading dose of 4 g should be given
intravenously over 5 minutes, followed by an
infusion of 1 g/hour maintained for 24 hours
recurrent seizures should be treated with a
further dose of 2–4 g given over 5 minutes.
Do not use diazepam, phenytoin as an
alternative to magnesium sulphate* in women
with eclampsia.
(NICE GUIDELINE)
31. Continous intravenous infusion
Give 4-6 gm of loading dose in 100 ml of IV fluid administered
over 15-20 min
Begin 2 gm/h in 50 ml of IV maintainance infusion
Measure serum magnesium level at 4-6 hrs and adjust between 4-7
meq/l
Magnesium sulfate is discontinued 24 hrs after delivery
32. Give loading dose of 4 g of magnesium sulfate as a 20% solution
intravenously at a rate of 1g/min
Follow with 10g of magnesium sulfate ,one half(5 g) injected deeply in the
upper outer quadrant of both buttocks using a 3-inch long 20 guage
needle
If convulsions persist after 15 minutes give 2 gm more IV as a
20%solution as 1g/min.,for a large women 4 gm can be given slowly and
safely
Every 4 hrs thereafter give 5 gm of Mg sulphate in alternate buttocks after
assuring
1. the patellar reflex is present
2. Respirations are not depressed
3. Urine output during the previous 4 hrs exceed 400ml
Discontinue 24 hrs after delivery
(William obstetrics)
33. Magnesium Sulfate –
First-line therapy for seizure prophylaxis.
Antagonizes calcium channels of smooth muscle.
Adult Dose 4-6 g IV over 20 min, with maintenance of 1-2 g/h
Contraindications Hypermagnesemia, heart block, severe
hepatitis renal disease, Addison disease, myocardial damage
Overdose calcium gluconate, 10-20 mL IV of 10%; serum
magnesium level should be checked one hour after initiation of
therapy with goal of therapeutic level of 4-7 mEq/L
34. Phenytoin (Dilantin) -- The major site of action is the motor cortex where it
acts by preventing the spread of seizure activity.
Indicated for eclampsia.
Adult Dose 20 mg/kg IV infused at a rate of 12.5 mg/min, not to exceed
1500 mg/24h
Contraindications Documented hypersensitivity, sinoatrial block, sinus
bradycardia, Adam-Stokes syndrome
Pregnancy D - Unsafe in pregnancy
Diazepam (Valium) -- For treatment of seizures resistant to magnesium
sulfate. Depresses all levels of CNS (eg, limbic and reticular formation),
possibly by increasing activity of GABA.
Indicated for status epilepticus in eclamptic patients.
Adult Dose 5-10 mg IV, repeat to total of 30 mg
Contraindications Documented hypersensitivity; narrow angle glaucoma
Fetal respiratory depression, fetal heart beat variability, maternal respiratory
depression, delivery of fetus imminent
Pregnancy D - Unsafe in pregnancy
Precautions Monitor respiratory status during administrati on
35. Corticosteroids for fetal lung maturation
• If birth is considered likely within 7 days in women with pre-
eclampsia:
give two doses of betamethasone* 12 mg intramuscularly 12
hours apart in women between 24 and 34 weeks
consider giving two doses of betamethasone* 12 mg
intramuscularly12 hours apart in women between 35 and 36
weeks.
Corticosteroids to manage HELLP syndrome
Do not use dexamethasone or betamethasone for the treatment of
HELLP syndrome.
36. Do not use volume expansion in women with
severe pre-eclampsia unless hydralazine is
the antenatal antihypertensive.
In women with severe pre-eclampsia, limit
maintenance fluids to 80 ml/hour unless there
are other ongoing fluid losses (for example,
haemorrhage).
37. Manage pregnancy in women with pre-eclampsia conservatively
(that is, do not plan same-day delivery of the baby) until 34 weeks.
Consultant obstetrician should document in the woman's notes the
maternal (biochemical, haematological and clinical) and fetal
thresholds for elective birth before 34 weeks in women with pre-
eclampsia.
Consultant obstetrician should write a plan for antenatal fetal
monitoring during birth.
Before 34 weeks
Offer birth to women with pre-eclampsia before 34 weeks, after
discussion with neonatal and anaesthetic teams and a course of
corticosteroids has been given if:
severe hypertension develops refractory to treatment
maternal or fetal indications develop as specified in the consultant
plan
38. After 34 weeks
Recommend birth for women who have pre-eclampsia
with severe hypertension after 34 weeks when their
blood pressure has been controlled and a course of
corticosteroids has been completed (if appropriate).
Between 34+0 to 36+6 weeks
Offer birth to women who have pre-eclampsia with mild
or moderate hypertension at 34+0 to 36+6 weeks
depending on maternal and fetal condition,risk factors
and availability of neonatal intensive care.
At 37+0 weeks
Recommend birth within 24–48 hours for women who
have pre-eclampsia with mild or moderate
hypertension after 37+0 weeks (nice guideline)
39. Carry out cardiotocography at diagnosis of severe
gestational hypertension or pre-eclampsia.
If conservative management of severe gestational
hypertension or pre-eclampsiais planned, carry out
all the following tests at diagnosis:
• ultrasound for fetal growth and amniotic fluid
volume assessment
• umbilical artery doppler velocimetry.
If the results of all fetal monitoring are normal in
women with severe gestational hypertension or pre-
eclampsia, do not routinely repeat cardiotocography
more than weekly.
In women with severe gestational hypertension or
pre-eclampsia, repeat cardiotocography if if any of
the following occur:
the woman reports a change in fetal movement
vaginal bleeding
abdominal pain
deterioration in maternal condition.
40. In women with severe gestational hypertension or pre-eclampsia, do
not routinely repeat ultrasound for fetal growth and amniotic fluid
volume assessment or umbilical artery doppler velocimetry more
than every 2 weeks.
If the results of any fetal monitoring in women with severe gestational
hypertension or pre-eclampsia are abnormal, tell a consultant
obstetrician
For women with severe gestational hypertension or pre-eclampsia,
write a careplan that includes all of the following:
o the timing and nature of future fetal monitoring
o fetal indications for birth and if and when corticosteroids should be
given
o when discussion with neonatal paediatricians and obstetric
anaesthetists should take place and what decisions should be made
41. Blood pressure
During labour, measure blood pressure:
• hourly in women with mild or moderate hypertension
• continually in women with severe hypertension.
• Continue use of antenatal antihypertensive treatment during labour.
Haematological and biochemical monitoring
Determine the need for haematological and biochemical tests during labour in
women with mild or moderate hypertension using the same criteria as in the
antenatal period even if regional analgesia is being considered.
Care during epidural analgesia
Do not preload women who have severe pre-eclampsia with intravenous fluids
before establishing low-dose epidural analgesia and combined spinal epidural
analgesia.
42. Do not routinely limit the duration of the
second stage of labour: in women with stable
mild or moderate hypertension or if blood
pressure is controlled within target ranges in
women with severe hypertension.
Recommend operative birth in the second stage
of labour for women with severe hypertension
whose hypertension has not responded to
initial treatment.
43. Blood pressure
In women with pre-eclampsia who did not take antihypertensive treatment and have
given birth, measure blood pressure:
at least four times a day while the woman is an inpatient
at least once between day 3 and day 5 after birth
on alternate days until normal if blood pressure was abnormal on days 3–5.
In women with pre-eclampsia who did not take antihypertensive treatment and have
given birth, start antihypertensive treatment if blood pressure is 150/100 mmHg or
higher.
Ask women with pre-eclampsia who have given birth about severe headache and
epigastric pain each time blood pressure is measured.
44. In women with pre-eclampsia who took
antihypertensive treatment and have given
birth, measure blood pressure:
o at least four times a day while the woman is an inpatient
o every 1–2 days for up to 2 weeks after transfer to
community care until the woman is off treatment and has no
hypertension.
For women with pre-eclampsia who have taken
antihypertensive treatment and have given
birth:
continue antenatal antihypertensive treatment
consider reducing antihypertensive treatment if their blood
pressure falls below 140/90 mmHg
45. reduce antihypertensive treatment if their blood pressure falls
below 130/80 mmHg.
If a woman has taken methyldopa† to treat pre-eclampsia, stop
within 2 days of birth.
Offer women with pre-eclampsia who have given birth transfer
to community care if all of the following criteria have been met:
1. there are no symptoms of pre-eclampsia
2. blood pressure, with or without treatment, is 149/99 mmHg or
lower
3. blood test results are stable or improving.
Write a care plan for women with pre-eclampsia who have given
birth and are being transferred to community care that includes
all of the following:
• who will provide follow-up care, including medical review if
needed
• frequency of blood pressure monitoring
• thresholds for reducing or stopping treatment
• indications for referral to primary care for blood pressure review
• self-monitoring for symptoms.
46. Offer women who have pre-eclampsia and are
still on antihypertensive treatment 2 weeks
after transfer to community care a medical
review.
Offer all women who have had pre-eclampsia a
medical review at the postnatal review (6–8
weeks after the birth).
Offer women who have had pre-eclampsia and
who still need antihypertensive treatment at
the postnatal review (6–8 weeks after the birth)
a specialist assessment of their hypertension.
47. Haematological and
biochemical monitoring
In women who have pre-eclampsia with mild
or moderate hypertension, measure platelet
count, transaminases and serum creatinine 48–
72 hours after birth
do not repeat platelet count, transaminases or
serum creatinine measurements if results are
normal at 48–72 hours.
If biochemical and haematological indices are
improving but stay within the abnormal range
repeat measurements as clinically indicated
and at the postnatal review (6–8 weeks after the
birth).
48. If biochemical and haematological indices are
not improving , repeat platelet count,
transaminases and serum creatinine
measurements as clinically indicated.
carry out a urinary reagent-strip test at the
postnatal review (6–8 weeks after the birth).
Offer women who had pre-eclampsia and still
have proteinuria (1+ or more) at the postnatal
review (6–8 weeks after the birth) a further
review at 3 months after the birth to assess
kidney function and consider offering them a
referral specialist kidney assessment.
49. In women who still need antihypertensive treatment in the postnatal period,avoid
diuretic treatment for hypertension if the woman is breastfeeding or expressing
milk.
Tell women who still need antihypertensive treatment in the postnatal period that
the following antihypertensive drugs have no known adverse effects on babies
receiving breast milk:
labetalol
nifedipine
enalapril
captopril
atenolol
metoprolol
Tell women who still need antihypertensive treatment in the postnatal period that
there is insufficient evidence on the safety in babies receiving breast milk of the
following antihypertensive drugs:
• ARBs
• amlodipine
• ACE inhibitors other than enalapril† and captopril†.
Assess the clinical wellbeing of the baby, especially adequacy of feeding, at least
daily for the first 2 days after the birth.
50. Long-term risk of cardiovascular disease
increased later in life
Long-term risk of end-stage kidney disease
Tell women with a history of pre-eclampsia who
have no proteinuria and no hypertension at the
postnatal review (6–8 weeks after the birth) that
although the relative risk of end-stage kidney
disease is increased the absolute risk is low and no
further follow-up is necessary
Thrombophilia and the risk of pre-eclampsia
Do not routinely perform screening for thrombophilia
in women who have had pre-eclampsia.
51. Risk of recurrence of hypertensive
disorders of pregnancy
Tell women who had gestational hypertension that their
risk of developing:
• gestational hypertension in a future pregnancy ranges from about
16 to 47%
• pre-eclampsia in a future pregnancy ranges from 2 to 14%
Tell women who had pre-eclampsia that their
• risk of gestational hypertension in a future pregnancy ranges
from about 13 to 53%
• pre-eclampsia in a future pregnancy is up to about (16%)
• pre-eclampsia in a future pregnancy is about (25%) pregnancies if
their preeclampsia was complicated by severe pre-eclampsia,
HELLP syndrome or eclampsia and led to birth before 34 weeks,
and about (55%) pregnancies if it led to birth before 28 weeks.
52. Inter-pregnancy interval and recurrence of
hypertensive disorders of pregnancy
Tell women who have had pre-eclampsia that there is no
additional risk of recurrence with inter-pregnancy interval
up to 10 years
Body mass index and recurrence of
hypertensive disorders of pregnancy
Advise women who have had pre-eclampsia to achieve and
keep a BMI within the healthy range before their next
pregnancy (18.5–24.9 kg/m2)