This randomized trial by Jorde et al demonstrated neutral effect of high dose vitamin D on lipids and glucose tolerance

1. www.pronutritionist.net
No improvement in cardiovascular
risk factors in overweight and
obese subjects after
supplementation with vitamin D3
for 1 year.
Jorde R et al.
J Intern Med 2010; 267(5): 462-472.
Page 1 Jorde R et al. J Intern Med 2010; 267(5): 462-472.

2. Page 2
Background
• Cross-sectional studies indicate vitamin D to be of importance
for
– glucose tolerance
– blood pressure
– serum lipids
• Whether supplementation with vitamin D would improve cardio-
vascular risk factors is not known
Jorde R et al. J Intern Med 2010; 267(5): 462-472. www.pronutritionist.net

3. Methods
• Double blind placebo-controlled intervention trial
• Duration 1 year
• n = 330
• Subjects were overweight or obese
• Presented results are secondary outcome measures
(primary end point was weight loss, reported earlier)
• Intervention:
– 40 000 IU (1000 µg) per week (DD group), ie. circa 140 µg/day
– 20 000 IU (500 µg ) per week (DP group), ie. circa 70 µg/day
– Placebo (PP group)
– All subjects were given 500 mg calcium daily
Page 3 Jorde R et al. J Intern Med 2010; 267(5): 462-472. www.pronutritionist.net

4. Results
• At baseline the mean serum 25(OH)D levels were
58 nmol L−1
(all subjects)
• Mean serum 25(OH)D levels increased
– to 140 nmol L−1
in DD group (40 000 IU vitamin D)
– to 101 nmol L−1
in DP group (20 000 IU vitamin D)
• No significant differences were found between the groups
regarding change in measures of glucose metabolism or
serum lipids.
• In the DP group, there was a slight but significant increase in
systolic blood pressure compared with the placebo group.
Page 4 Jorde R et al. J Intern Med 2010; 267(5): 462-472. www.pronutritionist.net

5. Discussion
• Results do not support a positive effect of vitamin D on
glucose tolerance, blood pressure or serum lipids.
• Further studies in subjects with low serum 25(OH)D levels
combined with impaired glucose tolerance, hypertension or
dyslipidaemia are needed.
• Potential positive effects of vitamin D on cardiovascular
health do not seem to be mediated via lipids or glucose
tolerance
• High doses (70-140 µg/d) used in the study were well
tolerated
Page 5 Jorde R et al. J Intern Med 2010; 267(5): 462-472. www.pronutritionist.net

6. Discussion
• Results do not support a positive effect of vitamin D on
glucose tolerance, blood pressure or serum lipids.
• Further studies in subjects with low serum 25(OH)D levels
combined with impaired glucose tolerance, hypertension or
dyslipidaemia are needed.
• Potential positive effects of vitamin D on cardiovascular
health do not seem to be mediated via lipids or glucose
tolerance
• High doses (70-140 µg/d) used in the study were well
tolerated
Page 5 Jorde R et al. J Intern Med 2010; 267(5): 462-472. www.pronutritionist.net