Mesopotamia, located between the Tigris and Euphrates Rivers in modern Iraq, was the site of some of the earliest human civilizations. People first settled there due to natural levees along the rivers that protected against floods while enabling irrigation. Several successive civilizations arose in Mesopotamia over 3000 years, including the Sumerians, Akkadians, Babylonians, and Assyrians. These civilizations developed systems of writing like cuneiform, advanced mathematics, the wheel, and organized religion centered around temples. Though Mesopotamia faced environmental challenges like flooding and lack of resources, its civilizations left lasting legacies as the cradle of modern civilization.