The document provides background information on Mesopotamia. It describes Mesopotamia as the earliest civilization known as the "Cradle of Civilization", located between the Tigris and Euphrates Rivers in present-day Iraq. It summarizes that the Sumerians who lived in southern Mesopotamia were the first to develop systems of writing, mathematics, wheeled vehicles, and metalworking. The document also briefly outlines the major peoples and empires that arose and fell in Mesopotamia over 3000 years, including the Sumerians, Akkadians, Babylonians, Assyrians, and Persians.