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C H A P T E R 1 – T H E H U M A N B O D Y : A N
O R I E N T A T I O N
ANATOMY & PHYSIOLOGY
A N O V E R V I E W O F A N A T O M Y A N D
P H Y S I O L O G Y
CHAPTER 1
Let’s start with the basics
 anatomy: the study of the structure and shape of the
body and its parts and their relationships to one another
 gross anatomy: the study of large body structures (human body)
 microscopic anatomy: the study of body structures too small to be
seen with the naked eye (cells and tissues)
 physiology: the study of how the body and its parts work
or function
They are ALWAYS related
 The parts of the body form a well-organized unit
 You want to view the body in terms of structure and
function
 Cardiovascular system
W H Y M U S T W E U S E L E V E L S O F
O R G A N I Z A T I O N ?
LEVELS OF ORGANIZATION
The basics
 Each level contains progressively larger structures
 The structure in each level is composed of structures
from the preceding level
Level 1 – Chemical Level
 Smallest level of organization
 From atoms up to molecules
 atoms: the building blocks of all matter
 ex. H, H2O
Level 2 – Cellular Level
 cells: the smallest unit of all living things
 Ex. neuron
Level 3 – Tissue Level
 tissue: consist of groups similar cells that have a
common function
 4 basic types (epithelial, connective, muscular,
neural)
 ex. neural tissue
Level 4 – Organ Level
 organ: structure composed of two or more tissues
types that performs a specific function
 at this level, extremely complex functions become
possible
 ex. brain
Level 5 – Organ System Level
 organ system: a group of organs that work together
to accomplish a common purpose
 ex. CNS
Level 6 – Organismal Level
 Organismal Level
 organism: an individual living thing composed of
multiple organ systems working together
 Humans use 11 organ systems
A N O V E R V I E W
THE HUMAN ORGAN
SYSTEMS
11 Organ Systems
 We will examine each system in more detail later in
the year
 Look at both the structures involved and how each of
these structures function both independently and
together
 Take note how the organ systems are interrelated
Integumentary System
 structure: skin (external covering of the body)
 function:
 1. waterproofs the body
 2. cushions and protects deeper tissues from injury
 3. excretes salts and urea during perspiration
 4. helps regulate body temperature
Skeletal System
 structure: bones, cartilages,
ligaments, joints
 function:
 1. supports the body
 2. provides a framework for
skeletal muscles
 3. protects some organs
 4. performs hematopoiesis
 hematopoiesis: formation of
blood cells
Muscular System
 structure: skeletal muscles
 function: to contract and to
allow movement
 viewed as the “machines” of
the body
 allows for locomotion,
maintains posture,
produces heat, etc.
Nervous System
 structure: brain, spinal cord, nerves, sensory receptors
(body’s fast-acting control system)
 function:
 1. respond to external stimuli
 2. respond to internal stimuli
 assesses information and responds by activating the
appropriate body effectors (muscles or glands)
Endocrine System
 structure: pituitary, thyroid, parathyroids, adrenals,
thymus, and pineal glands, pancreas, ovaries/testis
 function:
 1. controls body activities (slower than the nervous
system)
 2. produce and release hormones
Cardiovascular System
 structure: heart and blood vessels
 function:
 1. carries oxygen, nutrients,
hormones, and other substances to
and from tissue cells where
exchanges are made
 2. WBCs help protect the body from
foreign invaders (bacteria, toxins,
tumor cells)
Respiratory System
 structure: nasal passages,
pharynx, larynx (vocal cords),
trachea, bronchi and lungs,
 function:
 1. keeps body constantly supplied
with oxygen
 2. removes carbon dioxide from
the body
 thin walls of the air sacs allows
gases to be transported to and
from the lungs
Lymphatic System
 structure: lymphatic vessels,
lymph nodes, spleen, tonsils
 function: 1. returns fluid
leaked from the blood back to
the blood vessels
 2. help cleanse the blood and
house cells involved in
immunity
 complements the
cardiovascular system
Digestive System
 structure: (mouth -> anus)
 oral cavity (mouth), esophagus, stomach, small and large
intestines, rectum, anus
 function:
 1. breakdown food
 2. deliver products to the blood for dispersal to the body
cells
 3. reclaim water (large intestines)
 liver is a digestive organ because it produces bile, which
helps break down fats
 pancreas delivers digestive enzymes to the small
intestines, functionally a digestive organ
Diagram of the Digestive System
Urinary System (Excretory System)
 structure: kidneys, ureters,
bladder, urethra
 function:
 1. removes Nitrogen-containing
wastes from the blood in the form
of urine
 2. helps maintain salt and water
balance (electrolyte)
 3. regulates the acid-base balance
of the blood
Reproductive System
 structure:
 in males: testes, scrotum, penis, accessory glands,
and duct system
 in females: ovaries, uterine tubes, uterus, vagina
 function: to produce offspring
WHAT THINGS MUST HAPPEN IN
INDIVIDUAL ORGAN SYSTEMS AND
BETWEEN MULTIPLE ORGAN
SYSTEMS TO ALLOW THE HUMAN
BODY TO FUNCTION?
NECESSARY LIFE
FUNCTIONS
The basic idea
 all organisms must use and maintain necessary life
functions
 organ systems are interdependent
 it is important to establish which organ systems are
most directly related to each life function
What must happen:
 1. Maintain Boundaries
 2. Movement
 3. Responsiveness
 4. Digestion
 5. Metabolism
 6. Excretion
 7. Reproduction
 8. Growth
Maintaining Boundaries
 Maintaining Boundaries
 every living organism needs to maintain boundaries to
keep “insides” distinct from “outsides”
 every individual cell has a membrane (most semi- or
selectively permeable) (microscopic anatomy)
 the body is enclosed by the Integumentary system
(gross anatomy)
 protects internal organs from drying out
 protects internal organs from bacteria
 protects body from the damaging effects of heat, sunlight,
chemical substances, and the external environment
Movement
 movement: all activities promoted by the muscular
system
 muscular system provides the muscles
 skeletal system provides the bones the muscles pull
on as they work
 movement also occurs when substances are
propelled through the internal organs of the
cardiovascular, digestive and urinary systems
Responsiveness
 responsiveness: (also called irritability) is the ability
to sense changes in the environment and react to
them
 the nervous system is the most responsible for
responsiveness
 however, all body cells are irritable to some extent.
Digestion
 digestion: the process of breaking down ingested
food into simple molecules that can be absorbed into
the blood
 in the complex body this is performed by the
digestive system
Metabolism
 metabolism: a broad term that refers to all
chemical reactions that occur within body cells
 includes:
 breaking down complex molecules into simpler ones
 using Oxygen and nutrients to produce molecules of ATP
(adenosine triphosphate, the energy-rich molecules that
power cell activities)
 depends on the respiratory, digestive, and
cardiovascular systems
 mainly regulated by hormones secreted by the
glands on the endocrine system
Excretion
 excretion: the process of removing excreta (wastes)
from the body
 nonuseful substances produced during digestion and
metabolism must be removed
 several organ systems participate in excretion,
including the digestive and urinary systems
Reproduction
 reproduction: the production of offspring
 can occur at both the cellular and organismal levels
 ex. mitosis in cells, human reproduction
 task of the reproductive system, regulated precisely
by the hormones of the endocrine system
Growth
 growth: an increase in size, usually accomplished by
an increase in the number of cells
 for growth to occur, cell-constructing activities must
occur at a faster rate than cell-destroying ones
W H A T A R E T H E B A S I C S U B S T A N C E S
N E C E S S A R Y F O R H U M A N S U R V I V A L ?
SURVIVAL NEEDS
Survival Needs
 several factors necessary for maintaining life
 nutrients, Oxygen, water, appropriate temperature
and atmospheric pressure
 must be present in appropriate amounts; too much
or too little may be equally harmful
Survival Needs
 1. Nutrients
 body takes in through food
 contain the chemicals used for energy and cell building
 proteins, carbohydrates, etc
 2. Oxygen
 the chemical reactions that release energy from foods
require Oxygen
 approximately 20% of the air we breathe is Oxygen
(20.95%)
Survival Needs
 3. water
 60-80 % body weight, 65-75% in muscle, only 10% in fat
 50-60% in most people, women have a lower percentage
due to higher body fat
 single most abundant chemical substance in the body
 provides the fluid base for body secretions and excretions
(secretion is an active process/particle movement,
excretion is a passive process/waste removal)
 chiefly ingested from foods and liquids
 lost by evaporation and body excretions
Survival Needs
 4. body temperature
 must be maintained around 37°C or 98.6°F
 as temperature drops, metabolic reactions slow until
they stop
 as temperature rises, metabolic reactions speed up
and can proceed too rapidly
 at either extreme, death will occur
 most body heat is generated by the activity of skeletal
muscles
Survival Needs
 5. atmospheric pressure
 atmospheric pressure: the force exerted on the
surface of the body by the weight of the air
 breathing and the exchange of oxygen and carbon
dioxide in the lungs depend on appropriate
atmospheric pressure
WHAT IS HOMEOSTASIS?
WHY IS IT IMPORTANT?
HOMEOSTASIS
Homeostasis
 homeostasis: a state of body equilibrium or stable
internal environment of the body
 literally means “unchanging”
 (homeo = the same, stasis = standing still)
 dynamic state of equilibrium
 ex. blood pressure, waste accumulation, body
temperature
Homeostasis
 communication is key, and is mainly controlled by
the nervous and endocrine systems
 nerves
 bloodborne hormones
 The factor being regulated by homeostasis is the
variable
Homeostasis
 all homeostatic control mechanisms have at least
three components:
 1. A receptor
 2. A control center
 3. An effector
A receptor
 a receptor that responds to environmental changes
 some type of sensor that monitors and responds to
change
 stimulus: the change (pl. stimuli)
 sends information(input) to the second element (the
control center) along the afferent pathway
 the afferent pathway approaches the control center
A control center
 a control center that assesses changes
 determines the level at which a variable is to be
maintained
 analyzes the information it receives
 determines the appropriate course of action or response
The effector
 provides the means for the control center’s response
(output) to the stimulus
 information flows from control center to the effector
along the efferent pathway
 efferent information exits from the control center
 the results of the response feedback to influence the
stimulus
 either depresses (negative feedback) or enhances
(positive feedback)
Negative Feedback Systems
 Negative feedback mechanisms: the
net effect of the response to the
stimulus is to shut off the original
stimulus or reduce its intensity
 most homeostatic control
mechanisms
 ex. Home thermostat
 hypothalamus in the body
 also includes heart rate, blood
pressure, breathing rate, blood
nutrient levels
Positive Feedback Systems
 Positive feedback mechanisms: tend to increase the
original disturbance (stimulus) and to push the
variable farther from its original value
 rare in the body
 events that occur explosively
 ex. Blood clotting, birth
Homeostatic Imbalance
 Homeostasis is so important that most diseases can
be regarded as homeostatic imbalances
 as age increases, organ function decreases, and the
risk of disease/homeostatic imbalance as increases

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The Human Body: An Orientation

  • 1. C H A P T E R 1 – T H E H U M A N B O D Y : A N O R I E N T A T I O N ANATOMY & PHYSIOLOGY
  • 2. A N O V E R V I E W O F A N A T O M Y A N D P H Y S I O L O G Y CHAPTER 1
  • 3. Let’s start with the basics  anatomy: the study of the structure and shape of the body and its parts and their relationships to one another  gross anatomy: the study of large body structures (human body)  microscopic anatomy: the study of body structures too small to be seen with the naked eye (cells and tissues)  physiology: the study of how the body and its parts work or function
  • 4. They are ALWAYS related  The parts of the body form a well-organized unit  You want to view the body in terms of structure and function  Cardiovascular system
  • 5. W H Y M U S T W E U S E L E V E L S O F O R G A N I Z A T I O N ? LEVELS OF ORGANIZATION
  • 6. The basics  Each level contains progressively larger structures  The structure in each level is composed of structures from the preceding level
  • 7. Level 1 – Chemical Level  Smallest level of organization  From atoms up to molecules  atoms: the building blocks of all matter  ex. H, H2O
  • 8. Level 2 – Cellular Level  cells: the smallest unit of all living things  Ex. neuron
  • 9. Level 3 – Tissue Level  tissue: consist of groups similar cells that have a common function  4 basic types (epithelial, connective, muscular, neural)  ex. neural tissue
  • 10. Level 4 – Organ Level  organ: structure composed of two or more tissues types that performs a specific function  at this level, extremely complex functions become possible  ex. brain
  • 11. Level 5 – Organ System Level  organ system: a group of organs that work together to accomplish a common purpose  ex. CNS
  • 12. Level 6 – Organismal Level  Organismal Level  organism: an individual living thing composed of multiple organ systems working together  Humans use 11 organ systems
  • 13. A N O V E R V I E W THE HUMAN ORGAN SYSTEMS
  • 14. 11 Organ Systems  We will examine each system in more detail later in the year  Look at both the structures involved and how each of these structures function both independently and together  Take note how the organ systems are interrelated
  • 15. Integumentary System  structure: skin (external covering of the body)  function:  1. waterproofs the body  2. cushions and protects deeper tissues from injury  3. excretes salts and urea during perspiration  4. helps regulate body temperature
  • 16. Skeletal System  structure: bones, cartilages, ligaments, joints  function:  1. supports the body  2. provides a framework for skeletal muscles  3. protects some organs  4. performs hematopoiesis  hematopoiesis: formation of blood cells
  • 17. Muscular System  structure: skeletal muscles  function: to contract and to allow movement  viewed as the “machines” of the body  allows for locomotion, maintains posture, produces heat, etc.
  • 18. Nervous System  structure: brain, spinal cord, nerves, sensory receptors (body’s fast-acting control system)  function:  1. respond to external stimuli  2. respond to internal stimuli  assesses information and responds by activating the appropriate body effectors (muscles or glands)
  • 19. Endocrine System  structure: pituitary, thyroid, parathyroids, adrenals, thymus, and pineal glands, pancreas, ovaries/testis  function:  1. controls body activities (slower than the nervous system)  2. produce and release hormones
  • 20. Cardiovascular System  structure: heart and blood vessels  function:  1. carries oxygen, nutrients, hormones, and other substances to and from tissue cells where exchanges are made  2. WBCs help protect the body from foreign invaders (bacteria, toxins, tumor cells)
  • 21. Respiratory System  structure: nasal passages, pharynx, larynx (vocal cords), trachea, bronchi and lungs,  function:  1. keeps body constantly supplied with oxygen  2. removes carbon dioxide from the body  thin walls of the air sacs allows gases to be transported to and from the lungs
  • 22. Lymphatic System  structure: lymphatic vessels, lymph nodes, spleen, tonsils  function: 1. returns fluid leaked from the blood back to the blood vessels  2. help cleanse the blood and house cells involved in immunity  complements the cardiovascular system
  • 23. Digestive System  structure: (mouth -> anus)  oral cavity (mouth), esophagus, stomach, small and large intestines, rectum, anus  function:  1. breakdown food  2. deliver products to the blood for dispersal to the body cells  3. reclaim water (large intestines)  liver is a digestive organ because it produces bile, which helps break down fats  pancreas delivers digestive enzymes to the small intestines, functionally a digestive organ
  • 24. Diagram of the Digestive System
  • 25. Urinary System (Excretory System)  structure: kidneys, ureters, bladder, urethra  function:  1. removes Nitrogen-containing wastes from the blood in the form of urine  2. helps maintain salt and water balance (electrolyte)  3. regulates the acid-base balance of the blood
  • 26. Reproductive System  structure:  in males: testes, scrotum, penis, accessory glands, and duct system  in females: ovaries, uterine tubes, uterus, vagina  function: to produce offspring
  • 27. WHAT THINGS MUST HAPPEN IN INDIVIDUAL ORGAN SYSTEMS AND BETWEEN MULTIPLE ORGAN SYSTEMS TO ALLOW THE HUMAN BODY TO FUNCTION? NECESSARY LIFE FUNCTIONS
  • 28. The basic idea  all organisms must use and maintain necessary life functions  organ systems are interdependent  it is important to establish which organ systems are most directly related to each life function
  • 29. What must happen:  1. Maintain Boundaries  2. Movement  3. Responsiveness  4. Digestion  5. Metabolism  6. Excretion  7. Reproduction  8. Growth
  • 30. Maintaining Boundaries  Maintaining Boundaries  every living organism needs to maintain boundaries to keep “insides” distinct from “outsides”  every individual cell has a membrane (most semi- or selectively permeable) (microscopic anatomy)  the body is enclosed by the Integumentary system (gross anatomy)  protects internal organs from drying out  protects internal organs from bacteria  protects body from the damaging effects of heat, sunlight, chemical substances, and the external environment
  • 31. Movement  movement: all activities promoted by the muscular system  muscular system provides the muscles  skeletal system provides the bones the muscles pull on as they work  movement also occurs when substances are propelled through the internal organs of the cardiovascular, digestive and urinary systems
  • 32. Responsiveness  responsiveness: (also called irritability) is the ability to sense changes in the environment and react to them  the nervous system is the most responsible for responsiveness  however, all body cells are irritable to some extent.
  • 33. Digestion  digestion: the process of breaking down ingested food into simple molecules that can be absorbed into the blood  in the complex body this is performed by the digestive system
  • 34. Metabolism  metabolism: a broad term that refers to all chemical reactions that occur within body cells  includes:  breaking down complex molecules into simpler ones  using Oxygen and nutrients to produce molecules of ATP (adenosine triphosphate, the energy-rich molecules that power cell activities)  depends on the respiratory, digestive, and cardiovascular systems  mainly regulated by hormones secreted by the glands on the endocrine system
  • 35. Excretion  excretion: the process of removing excreta (wastes) from the body  nonuseful substances produced during digestion and metabolism must be removed  several organ systems participate in excretion, including the digestive and urinary systems
  • 36. Reproduction  reproduction: the production of offspring  can occur at both the cellular and organismal levels  ex. mitosis in cells, human reproduction  task of the reproductive system, regulated precisely by the hormones of the endocrine system
  • 37. Growth  growth: an increase in size, usually accomplished by an increase in the number of cells  for growth to occur, cell-constructing activities must occur at a faster rate than cell-destroying ones
  • 38. W H A T A R E T H E B A S I C S U B S T A N C E S N E C E S S A R Y F O R H U M A N S U R V I V A L ? SURVIVAL NEEDS
  • 39. Survival Needs  several factors necessary for maintaining life  nutrients, Oxygen, water, appropriate temperature and atmospheric pressure  must be present in appropriate amounts; too much or too little may be equally harmful
  • 40. Survival Needs  1. Nutrients  body takes in through food  contain the chemicals used for energy and cell building  proteins, carbohydrates, etc  2. Oxygen  the chemical reactions that release energy from foods require Oxygen  approximately 20% of the air we breathe is Oxygen (20.95%)
  • 41. Survival Needs  3. water  60-80 % body weight, 65-75% in muscle, only 10% in fat  50-60% in most people, women have a lower percentage due to higher body fat  single most abundant chemical substance in the body  provides the fluid base for body secretions and excretions (secretion is an active process/particle movement, excretion is a passive process/waste removal)  chiefly ingested from foods and liquids  lost by evaporation and body excretions
  • 42. Survival Needs  4. body temperature  must be maintained around 37°C or 98.6°F  as temperature drops, metabolic reactions slow until they stop  as temperature rises, metabolic reactions speed up and can proceed too rapidly  at either extreme, death will occur  most body heat is generated by the activity of skeletal muscles
  • 43. Survival Needs  5. atmospheric pressure  atmospheric pressure: the force exerted on the surface of the body by the weight of the air  breathing and the exchange of oxygen and carbon dioxide in the lungs depend on appropriate atmospheric pressure
  • 44. WHAT IS HOMEOSTASIS? WHY IS IT IMPORTANT? HOMEOSTASIS
  • 45. Homeostasis  homeostasis: a state of body equilibrium or stable internal environment of the body  literally means “unchanging”  (homeo = the same, stasis = standing still)  dynamic state of equilibrium  ex. blood pressure, waste accumulation, body temperature
  • 46. Homeostasis  communication is key, and is mainly controlled by the nervous and endocrine systems  nerves  bloodborne hormones  The factor being regulated by homeostasis is the variable
  • 47. Homeostasis  all homeostatic control mechanisms have at least three components:  1. A receptor  2. A control center  3. An effector
  • 48. A receptor  a receptor that responds to environmental changes  some type of sensor that monitors and responds to change  stimulus: the change (pl. stimuli)  sends information(input) to the second element (the control center) along the afferent pathway  the afferent pathway approaches the control center
  • 49. A control center  a control center that assesses changes  determines the level at which a variable is to be maintained  analyzes the information it receives  determines the appropriate course of action or response
  • 50. The effector  provides the means for the control center’s response (output) to the stimulus  information flows from control center to the effector along the efferent pathway  efferent information exits from the control center  the results of the response feedback to influence the stimulus  either depresses (negative feedback) or enhances (positive feedback)
  • 51. Negative Feedback Systems  Negative feedback mechanisms: the net effect of the response to the stimulus is to shut off the original stimulus or reduce its intensity  most homeostatic control mechanisms  ex. Home thermostat  hypothalamus in the body  also includes heart rate, blood pressure, breathing rate, blood nutrient levels
  • 52. Positive Feedback Systems  Positive feedback mechanisms: tend to increase the original disturbance (stimulus) and to push the variable farther from its original value  rare in the body  events that occur explosively  ex. Blood clotting, birth
  • 53. Homeostatic Imbalance  Homeostasis is so important that most diseases can be regarded as homeostatic imbalances  as age increases, organ function decreases, and the risk of disease/homeostatic imbalance as increases