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International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072
© 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 1681
Adaptive Fractional Order PID Controller Design of a Pacemaker based
on Heart Rate Control Strategy
Adnan Mukhtar1, Farhan Mukhtar2
1Electrical and Electronics Engineering Department, Amity University Uttar Pradesh, Noida, 201303, India
2Automobile Engineering Department, Manav Rachna International Institute of Research and Studies Faridabad,
Haryana, 121004, India
------------------------------------------------------------------------***-------------------------------------------------------------------------
Abstract- At present, most of the patients with irregular
heartbeats especially the men complain that they undergo
shallow breathing. Shallow breathing takes place when the
heart does not properly pump blood to the lungs. There is a
rapid growth of shallow breathing cases and its impact is
significant on the health of patients. When a heart beats too
slowly or unevenly, it does not deliver blood and oxygen to
the body properly and effectively. These problems can be
overcome, by designing a proper controller or control
system that will regulate the heartbeats properly and
effectively. This paper mainly emphasizes the design of the
Proportional-Integral-Derivative controller (PID), Tilt-
Integral-Derivative controller (TID), Fractional Order PI
controller (FOPI), and Fractional Order PID controller
(FOPID) based on heart rate control strategy of a
pacemaker.
Keywords: Artificial Intelligence (AI), FOPID
Controller, IAE, ITAE, Genetic Algorithm (GA), TID
Controller
1. INTRODUCTION
The human being’s heart is a muscular internal organ
about the size of a human fist [1]. It lies just behind and
slightly to the left of the breastbone [3]. It pumps blood
through the mesh of veins and arteries. The blood supplies
the essential nutrients and oxygen (O2) to the human body
and aids in removing metabolic wastes [2]. The blood
through the mesh of veins and arteries must flow in a
normal pattern. When the blood flows too slowly or
unevenly through the veins and arteries, it causes shallow
breathing. The diagnosing process of irregularities of a
human being's heart is very essential otherwise; the
sufficient amount of blood and oxygen will not flow to the
body [4], [5]. The irregularities in a patient’s heart can be
monitored and detected using electrocardiography (ECG)
[10]. It is possible to save human beings from heart
problems by properly and continuously measuring and
observing the variations in the pattern of electrical signals
[4], [5]. Heart diseases are rapidly growing and their
impact on the health of human beings is significant. Heart
diseases arise due to stress, anxiety, thinking, and so on.
To get over the heart diseases, pacemakers are used to
regulate and maintain the heart rate by sending electrical
signals to the heart thus save human beings from minor
and major heart attacks [6].
In literature, various methodologies are available that
regulate and maintain the heart rate of a human. In this
work, PID, TID, Fractional Order PI, and Fractional Order
PID controllers are designed to maintain and regulate the
heart rate based on heart rate pacemaker control strategy.
To achieve better results, these controllers are tuned/
optimized using an artificial intelligence technique;
Genetic Algorithm (GA). PID is feasible, robust and its
concept is simple. TID resembles with PID but the tilted
gain replaces the proportional gain It is easy to tune than
PID [8]. FOPID being an advanced PID controller is more
robust and flexible than PID and TID because it has five
gain parameters [9]. Moreover, it yields better output
responses. GA is easy to understand, it can be easily
incorporated and it has robust parameters, it has a simple
concept, and better efficiency [7]. The three controllers are
compared based on peak value (PV), settling time (ST),
steady-state error (ESS), Integral of Time Multiplied by
Absolute Error (ITAE), and Integral of Absolute Error
(IAE). The entire work is carried out in
MATLAB/SIMULINK.
This work is organized as: section 2 explains the system
description, section 3 explains the simulation work, and
section 4 discusses the conclusion.
2. SYSTEM DESCRIPTION
A. 2.1 Pacemaker
A pacemaker (PM) is a device that stimulates the muscles
of the patient’s heart when it beats too slowly or unevenly
or when the patient undergoes shallow breathing. It
comprises of a sensing part and an output part [4].
a. Sensing Part: This part of the pacemaker helps in
sensing the heart rate of a patient.
b. Output Part: This part of the pacemaker helps in
sending electrical signals to the muscles of the patient’s
heart, thus regulate the heart rate of a patient.
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072
© 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 1682
2.2 Mathematical Modeling
Fig. 1 shows the conduction model of the heart [11-12].
Fig -1: Conduction Model of Heart
The various components of this model are tabulated in
Table I.
Table I. COMPONENTS OF CONDUCTION MODEL
S.NO Components Values
01 Capacitor 1 µF
02 Resistor 1 ῼ
The sum of currents flowing through the capacitor and the
resistor is the stimulus current [11]
(1)
Where Is is the stimulus current, IC and Ir are the currents
flowing through the capacitor and resistor respectively.
(2)
The drop in voltage across the membrane due to the
current flowing is [11]
(3)
Now, if a load of pacemaker is assumed to be fixed, then
[11] gives the equation of energy
(4)
Where W is the energy usage, Z is the load impedance, and
t is the stimulus time.
2.3 Types of Controllers
The controllers used in this paper to regulate the heart
rate based on the pacemaker are
1. Proportional-Integral-Derivative Controller (PID)
2. Tilt-Integral-Derivative Controller (TID)
3. Fractional Order Proportional-Integral Controller
(FOPI)
4. Fractional Order Proportional-Integral-Derivative
Controller (FOPID)
The controller gains of these controllers based on Genetic
Algorithm (GA) are tabulated in Table II.
Table II. CONTROLLER PARAMETERS
S.NO Controller
Gains
GA-
PID
GA-TID GA-
FOPI
GA-
FOPID
01 KP 6.1900 0.3707 0.3553
02 KI 4.1528 15.8070 0.0290 0.0089
03 KD 9.9031 6.5702 0.0043
04 KT 13.8795
05 λ 0.2310 0.0321
06 µ 0.3104 0.2134
3. SIMULATION RESULTS
The SIMULINK model of the pacemaker is shown in Fig. 1
[4], [5], [10].
Fig -2: SIMULINK Model of Pacemaker
The SIMULINK models, output responses, and error
responses of a pacemaker with PID, TID, FOPI, and FOPID
controllers are shown in Fig. 3-Fig. 15 and the results are
tabulated in Table. III
Fig -3: SIMULINK Model of Pacemaker with PID controller
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072
© 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 1683
Fig -4: SIMULINK Model of Pacemaker with TID controller
Fig -5: SIMULINK Model of Pacemaker with FOPI
controller
Fig -6: SIMULINK Model of Pacemaker with FOPID
controller
Fig -7: Output Response of Pacemaker with PID controller
Fig -8: Output Response of Pacemaker with TID controller
0 2 4 6 8 10 12 14 16 18 20
0
10
20
30
40
50
60
70
80
90
100
Time (sec)
Pulse
Reference
GA-PID
0 2 4 6 8 10 12 14 16 18 20
0
10
20
30
40
50
60
70
80
90
100
Time (sec)
Pulse
Reference
GA-TID
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072
© 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 1684
Fig -9: Output Response of Pacemaker with FOPI
controller
Fig -10: Output Response of Pacemaker with FOPID
controller
Fig -11: Overall Output Response of Pacemaker
Fig -12: Error Response with PID controller
Fig -13: Error Response with TID controller
Fig -14: Error Response with FOPI controller
0 2 4 6 8 10 12 14 16 18 20
0
10
20
30
40
50
60
70
80
90
100
Time (sec)
Pulse
Reference
GA-FOPI
0 2 4 6 8 10 12 14 16 18 20
0
10
20
30
40
50
60
70
80
90
100
Time (sec)
Pulse
Reference
GA-FOPID
0 2 4 6 8 10 12 14 16 18 20
0
10
20
30
40
50
60
70
80
90
100
Time (sec)
Pulse
Reference
GA-PID
GA-TID
GA-FOPI
GA-FOPID
0 2 4 6 8 10 12 14 16 18 20
0
100
200
300
400
500
600
Time (sec)
Error
ITAE
IAE
0 2 4 6 8 10 12 14 16 18 20
0
5
10
15
20
25
30
35
40
45
50
Time (sec)
Error
ITAE
IAE
0 2 4 6 8 10 12 14 16 18 20
0
5
10
15
20
25
30
Time (sec)
Error
ITAE
IAE
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056
Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072
© 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 1685
Fig -15: Error Response of Pacemaker with FOPID
controller
Table III. COMPARISON BETWEEN PID, TID, FOPI AND
FOPID CONTROLLERS
S.NO Specifications GA-
PID
GA-
TID
GA-
FOPI
GA-
FOPID
01 PV (pu) 94.526 89.81
2
77.56
4
75.601
02 ST (sec) 15.213 6
.316
3.431 3 .238
03 ESS 0.32 0.15 0 0
04 ITAE 519.1 49.6 19.3 7.79
05 IAE 151.7 47.5 28.8 27.5
4. CONCLUSION
Heart rates indicate different types of heart diseases. The
basis of the pacemaker is heart rate. The patients with
irregularities such as shallow breathing must use
pacemakers. In this paper, to achieve better output
responses, PID, TID, FOPI, and FOPID controllers with the
GA technique are designed to maintain and regulate the
heart rate of a patient. Based on the output responses, the
performance shown by the FOPID controller is far better
than PID, TID, and FOPI controllers. The quantitative
comparison of time-domain specifications viz.- peak value,
settling time, steady-state error, ITAE value, IAE value
with GA-FOPID indicate much superior performance.
REFERENCES
1) Taber, Clarence Wilbur, Venes Donald (2009).
Taber’s cyclopedic medical dictionary, F. A. Davis Co,
Pp: 1018-1023.
2) Hall, John (2011). Guyton and Hall textbook of
medical physiology (12th ed.), Philadelphia: Saunder,
Elsevier, P: 157.
3) Moore, Keith L.; Dalley, Arthur F.; Agur, Anne M. R.
(2009), Clinically Oriented Anatomy, Wolters Kluwel
Health/Lippincott Williams & Wilkins, Pp. 127–173.
4) Jyoti Yadav, Asha Rani, and Girisha Garg, “Intelligent
Heart Rate Controller for Cardiac Pacemaker”,
International Journal of Computer Applications,
December-2011, Pp: 22-29.
5) Aysan Esgandanian and Sabalan Daneshvar, “A
Comparative Study on a Tilt-Integral-Derivative
Controller with Proportional-Integral-Derivative
Controller for a Pacemaker”, International Journal of
Advanced Biotechnology and Research (IJBR), April-
2016 Pp: 645-650.
6) Wei Vivien Shi and Meng Chu Zhou, “Body Sensors
Applied in Pacemakers: A Survey”, IEEE Sensors
Journal, June-2012, Pp: 1817-1827.
7) Adnan Mukhtar, Vijay Kumar Tayal and H. P. Singh,
“PSO Optimized PID controller Design for the Process
Liquid Level Control”, 3rd International Conference
on Recent Developments in Automation, Control, and
Power Engineering, Pp: 590-593, February 2020.
8) Pretty Topno and Saurabh Chanana, “Automatic
generation control using optimally tuned tilt integral
derivative controller”, First International Conference
on Control, Measurement, and Instrumentation
(CMI), January-2016.
9) Aysan Esgandanian1 and Sabalan Daneshvar, “A
Comparative Study on a Tilt-Integral-Derivative
Controller with Proportional-Integral-Derivative
Controller for a Pacemaker”, International Journal of
Advanced Biotechnology and Research (IJBR),
Volume 7, Issue 3, Pp: 645-650, April-2016.
10) Mohamed I. Elnaggar, Heba A. El-Khobby, Amira S.
Ashourl Yanhui Guo, and Mustafa M. Abd Elnaby, “An
Optimized Mamdani FPD Controller Design of
Cardiac Pacemaker”, Projects: Biomedical
Engineering, Pp: 1-32, November-2018.
11) Anissia Beainy, George El-Jamal, Ziad Bou Sakr, and
Nazih Moubayed, “Mathematical Modeling of
Pacemaker for Study of Battery Longevity”,
International Conference on e-Technologies and
Networks for Development, Pp: 131-134.
12) R. Sutton I., Bourgeois, “The Foundations of Cardiac
Pacing. Part I”, Futura Publishing Company, Mount
Kisco, NY, 1991.
0 2 4 6 8 10 12 14 16 18 20
0
5
10
15
20
25
30
Time (sec)
Error
ITAE
IAE

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IRJET - Adaptive Fractional Order PID Controller Design of a Pacemaker based on Heart Rate Control Strategy

  • 1. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072 © 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 1681 Adaptive Fractional Order PID Controller Design of a Pacemaker based on Heart Rate Control Strategy Adnan Mukhtar1, Farhan Mukhtar2 1Electrical and Electronics Engineering Department, Amity University Uttar Pradesh, Noida, 201303, India 2Automobile Engineering Department, Manav Rachna International Institute of Research and Studies Faridabad, Haryana, 121004, India ------------------------------------------------------------------------***------------------------------------------------------------------------- Abstract- At present, most of the patients with irregular heartbeats especially the men complain that they undergo shallow breathing. Shallow breathing takes place when the heart does not properly pump blood to the lungs. There is a rapid growth of shallow breathing cases and its impact is significant on the health of patients. When a heart beats too slowly or unevenly, it does not deliver blood and oxygen to the body properly and effectively. These problems can be overcome, by designing a proper controller or control system that will regulate the heartbeats properly and effectively. This paper mainly emphasizes the design of the Proportional-Integral-Derivative controller (PID), Tilt- Integral-Derivative controller (TID), Fractional Order PI controller (FOPI), and Fractional Order PID controller (FOPID) based on heart rate control strategy of a pacemaker. Keywords: Artificial Intelligence (AI), FOPID Controller, IAE, ITAE, Genetic Algorithm (GA), TID Controller 1. INTRODUCTION The human being’s heart is a muscular internal organ about the size of a human fist [1]. It lies just behind and slightly to the left of the breastbone [3]. It pumps blood through the mesh of veins and arteries. The blood supplies the essential nutrients and oxygen (O2) to the human body and aids in removing metabolic wastes [2]. The blood through the mesh of veins and arteries must flow in a normal pattern. When the blood flows too slowly or unevenly through the veins and arteries, it causes shallow breathing. The diagnosing process of irregularities of a human being's heart is very essential otherwise; the sufficient amount of blood and oxygen will not flow to the body [4], [5]. The irregularities in a patient’s heart can be monitored and detected using electrocardiography (ECG) [10]. It is possible to save human beings from heart problems by properly and continuously measuring and observing the variations in the pattern of electrical signals [4], [5]. Heart diseases are rapidly growing and their impact on the health of human beings is significant. Heart diseases arise due to stress, anxiety, thinking, and so on. To get over the heart diseases, pacemakers are used to regulate and maintain the heart rate by sending electrical signals to the heart thus save human beings from minor and major heart attacks [6]. In literature, various methodologies are available that regulate and maintain the heart rate of a human. In this work, PID, TID, Fractional Order PI, and Fractional Order PID controllers are designed to maintain and regulate the heart rate based on heart rate pacemaker control strategy. To achieve better results, these controllers are tuned/ optimized using an artificial intelligence technique; Genetic Algorithm (GA). PID is feasible, robust and its concept is simple. TID resembles with PID but the tilted gain replaces the proportional gain It is easy to tune than PID [8]. FOPID being an advanced PID controller is more robust and flexible than PID and TID because it has five gain parameters [9]. Moreover, it yields better output responses. GA is easy to understand, it can be easily incorporated and it has robust parameters, it has a simple concept, and better efficiency [7]. The three controllers are compared based on peak value (PV), settling time (ST), steady-state error (ESS), Integral of Time Multiplied by Absolute Error (ITAE), and Integral of Absolute Error (IAE). The entire work is carried out in MATLAB/SIMULINK. This work is organized as: section 2 explains the system description, section 3 explains the simulation work, and section 4 discusses the conclusion. 2. SYSTEM DESCRIPTION A. 2.1 Pacemaker A pacemaker (PM) is a device that stimulates the muscles of the patient’s heart when it beats too slowly or unevenly or when the patient undergoes shallow breathing. It comprises of a sensing part and an output part [4]. a. Sensing Part: This part of the pacemaker helps in sensing the heart rate of a patient. b. Output Part: This part of the pacemaker helps in sending electrical signals to the muscles of the patient’s heart, thus regulate the heart rate of a patient.
  • 2. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072 © 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 1682 2.2 Mathematical Modeling Fig. 1 shows the conduction model of the heart [11-12]. Fig -1: Conduction Model of Heart The various components of this model are tabulated in Table I. Table I. COMPONENTS OF CONDUCTION MODEL S.NO Components Values 01 Capacitor 1 µF 02 Resistor 1 ῼ The sum of currents flowing through the capacitor and the resistor is the stimulus current [11] (1) Where Is is the stimulus current, IC and Ir are the currents flowing through the capacitor and resistor respectively. (2) The drop in voltage across the membrane due to the current flowing is [11] (3) Now, if a load of pacemaker is assumed to be fixed, then [11] gives the equation of energy (4) Where W is the energy usage, Z is the load impedance, and t is the stimulus time. 2.3 Types of Controllers The controllers used in this paper to regulate the heart rate based on the pacemaker are 1. Proportional-Integral-Derivative Controller (PID) 2. Tilt-Integral-Derivative Controller (TID) 3. Fractional Order Proportional-Integral Controller (FOPI) 4. Fractional Order Proportional-Integral-Derivative Controller (FOPID) The controller gains of these controllers based on Genetic Algorithm (GA) are tabulated in Table II. Table II. CONTROLLER PARAMETERS S.NO Controller Gains GA- PID GA-TID GA- FOPI GA- FOPID 01 KP 6.1900 0.3707 0.3553 02 KI 4.1528 15.8070 0.0290 0.0089 03 KD 9.9031 6.5702 0.0043 04 KT 13.8795 05 λ 0.2310 0.0321 06 µ 0.3104 0.2134 3. SIMULATION RESULTS The SIMULINK model of the pacemaker is shown in Fig. 1 [4], [5], [10]. Fig -2: SIMULINK Model of Pacemaker The SIMULINK models, output responses, and error responses of a pacemaker with PID, TID, FOPI, and FOPID controllers are shown in Fig. 3-Fig. 15 and the results are tabulated in Table. III Fig -3: SIMULINK Model of Pacemaker with PID controller
  • 3. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072 © 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 1683 Fig -4: SIMULINK Model of Pacemaker with TID controller Fig -5: SIMULINK Model of Pacemaker with FOPI controller Fig -6: SIMULINK Model of Pacemaker with FOPID controller Fig -7: Output Response of Pacemaker with PID controller Fig -8: Output Response of Pacemaker with TID controller 0 2 4 6 8 10 12 14 16 18 20 0 10 20 30 40 50 60 70 80 90 100 Time (sec) Pulse Reference GA-PID 0 2 4 6 8 10 12 14 16 18 20 0 10 20 30 40 50 60 70 80 90 100 Time (sec) Pulse Reference GA-TID
  • 4. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072 © 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 1684 Fig -9: Output Response of Pacemaker with FOPI controller Fig -10: Output Response of Pacemaker with FOPID controller Fig -11: Overall Output Response of Pacemaker Fig -12: Error Response with PID controller Fig -13: Error Response with TID controller Fig -14: Error Response with FOPI controller 0 2 4 6 8 10 12 14 16 18 20 0 10 20 30 40 50 60 70 80 90 100 Time (sec) Pulse Reference GA-FOPI 0 2 4 6 8 10 12 14 16 18 20 0 10 20 30 40 50 60 70 80 90 100 Time (sec) Pulse Reference GA-FOPID 0 2 4 6 8 10 12 14 16 18 20 0 10 20 30 40 50 60 70 80 90 100 Time (sec) Pulse Reference GA-PID GA-TID GA-FOPI GA-FOPID 0 2 4 6 8 10 12 14 16 18 20 0 100 200 300 400 500 600 Time (sec) Error ITAE IAE 0 2 4 6 8 10 12 14 16 18 20 0 5 10 15 20 25 30 35 40 45 50 Time (sec) Error ITAE IAE 0 2 4 6 8 10 12 14 16 18 20 0 5 10 15 20 25 30 Time (sec) Error ITAE IAE
  • 5. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395-0056 Volume: 07 Issue: 03 | Mar 2020 www.irjet.net p-ISSN: 2395-0072 © 2020, IRJET | Impact Factor value: 7.34 | ISO 9001:2008 Certified Journal | Page 1685 Fig -15: Error Response of Pacemaker with FOPID controller Table III. COMPARISON BETWEEN PID, TID, FOPI AND FOPID CONTROLLERS S.NO Specifications GA- PID GA- TID GA- FOPI GA- FOPID 01 PV (pu) 94.526 89.81 2 77.56 4 75.601 02 ST (sec) 15.213 6 .316 3.431 3 .238 03 ESS 0.32 0.15 0 0 04 ITAE 519.1 49.6 19.3 7.79 05 IAE 151.7 47.5 28.8 27.5 4. CONCLUSION Heart rates indicate different types of heart diseases. The basis of the pacemaker is heart rate. The patients with irregularities such as shallow breathing must use pacemakers. In this paper, to achieve better output responses, PID, TID, FOPI, and FOPID controllers with the GA technique are designed to maintain and regulate the heart rate of a patient. Based on the output responses, the performance shown by the FOPID controller is far better than PID, TID, and FOPI controllers. The quantitative comparison of time-domain specifications viz.- peak value, settling time, steady-state error, ITAE value, IAE value with GA-FOPID indicate much superior performance. REFERENCES 1) Taber, Clarence Wilbur, Venes Donald (2009). Taber’s cyclopedic medical dictionary, F. A. Davis Co, Pp: 1018-1023. 2) Hall, John (2011). Guyton and Hall textbook of medical physiology (12th ed.), Philadelphia: Saunder, Elsevier, P: 157. 3) Moore, Keith L.; Dalley, Arthur F.; Agur, Anne M. R. (2009), Clinically Oriented Anatomy, Wolters Kluwel Health/Lippincott Williams & Wilkins, Pp. 127–173. 4) Jyoti Yadav, Asha Rani, and Girisha Garg, “Intelligent Heart Rate Controller for Cardiac Pacemaker”, International Journal of Computer Applications, December-2011, Pp: 22-29. 5) Aysan Esgandanian and Sabalan Daneshvar, “A Comparative Study on a Tilt-Integral-Derivative Controller with Proportional-Integral-Derivative Controller for a Pacemaker”, International Journal of Advanced Biotechnology and Research (IJBR), April- 2016 Pp: 645-650. 6) Wei Vivien Shi and Meng Chu Zhou, “Body Sensors Applied in Pacemakers: A Survey”, IEEE Sensors Journal, June-2012, Pp: 1817-1827. 7) Adnan Mukhtar, Vijay Kumar Tayal and H. P. Singh, “PSO Optimized PID controller Design for the Process Liquid Level Control”, 3rd International Conference on Recent Developments in Automation, Control, and Power Engineering, Pp: 590-593, February 2020. 8) Pretty Topno and Saurabh Chanana, “Automatic generation control using optimally tuned tilt integral derivative controller”, First International Conference on Control, Measurement, and Instrumentation (CMI), January-2016. 9) Aysan Esgandanian1 and Sabalan Daneshvar, “A Comparative Study on a Tilt-Integral-Derivative Controller with Proportional-Integral-Derivative Controller for a Pacemaker”, International Journal of Advanced Biotechnology and Research (IJBR), Volume 7, Issue 3, Pp: 645-650, April-2016. 10) Mohamed I. Elnaggar, Heba A. El-Khobby, Amira S. Ashourl Yanhui Guo, and Mustafa M. Abd Elnaby, “An Optimized Mamdani FPD Controller Design of Cardiac Pacemaker”, Projects: Biomedical Engineering, Pp: 1-32, November-2018. 11) Anissia Beainy, George El-Jamal, Ziad Bou Sakr, and Nazih Moubayed, “Mathematical Modeling of Pacemaker for Study of Battery Longevity”, International Conference on e-Technologies and Networks for Development, Pp: 131-134. 12) R. Sutton I., Bourgeois, “The Foundations of Cardiac Pacing. Part I”, Futura Publishing Company, Mount Kisco, NY, 1991. 0 2 4 6 8 10 12 14 16 18 20 0 5 10 15 20 25 30 Time (sec) Error ITAE IAE