This document presents a comparative study on the seismic response of 20-story regular and irregular reinforced concrete frame structures with and without base isolation under near-field and far-field ground motions. Nonlinear time history analyses were conducted using Kobe (HIK) and Bhuj earthquake records to represent far-field and near-field ground motions, respectively. Lead rubber bearings were used as the base isolation system. Parameters such as base shear, displacement, drift, and acceleration were compared for regular and irregular structures with fixed and isolated bases under both near-field and far-field ground motions. In general, base shear, displacement, and drift decreased for structures with base isolation compared to fixed base, and seismic response was greater under