Why just one sperm can enter the secondary oocyte? Why just one sperm can enter the secondary oocyte? Solution Sperm fuses with the egg and fertilizes it. Normally only one sperm fuses with an egg and if more than one sperm fuses this is called polyspermy.Development of the zygote usually stops if polyspermy occurs and in most cases, the egg cell blocks polyspermy. In polyspermy,multipolar or extra miotic spindles are formed which stop the fertilized egg development by causing faulty segregation of chromosomes during cell division. The egg plasma prevent polyspermy by depolarising the egg plasma membranes after the first sperm cell fuses with the egg cell. Thus preventing further sperm from fusing, this is the primary block to polyspermy. The secondary block to polyspermy is by the cortical reaction within the egg cell . the fusion of the sperm with an egg plasma membrane causes an increase in cytosolic calcium within the egg. The calcium activates the egg to begin development, which initiates a cortical reaction that releases various enzymes that change the structure of the outside layer of the egg. This hardens the zona pellucida which prevents another sperm from binding to it..