Solubility in water happens when something is polar or charged. Charged is much easier to understand--it\'s when there\'s an actual positive or negative charge on any given molecule. Polarity is just like charge, but instead of the electrons being specifically on a given atom and not on another (like in Na+ and Cl-), they\'re shared in a way such that they spend more time on one atom vs another (like CH3OH--the electrons spend more time on the O than they do on either the C or the Hs). How do you know which atoms like to hold onto electrons more than other atoms? Electronegativity differences. Certain atoms like F, N, and O are really electronegative, which means they like to hold onto electrons more than other atoms, like, say, C and H. So, if F were bound to C, the electrons would be on the F more often than the C. On the other hand, if you have to atoms, like C and H, which have very similar electronegativity values, they will share the electrons more readily, and the electrons don\'t stay on one or the other atoms more often. Such molecules are called non-polar, and are, in fact, not soluble in water. Instead, they\'re fat-soluble, because fat is just a whole bunch of C-H bonds next to each other. So, looking at the structures of those given vitamins, vitamin A consists mostly of a bunch of C-H bonds; it\'s likely fat soluble. Vitamin B6 has a bunch of C-O-H bonds and an N, too. It\'s much more polar, and likely water soluble. Vitamin C has tons of oxygens and is definitely water soluble. Vitamin E is mostly C-H bonds and not too many O-H or O-C bonds, so it\'s likely fat soluble. Hope that helps! :) Solution Solubility in water happens when something is polar or charged. Charged is much easier to understand--it\'s when there\'s an actual positive or negative charge on any given molecule. Polarity is just like charge, but instead of the electrons being specifically on a given atom and not on another (like in Na+ and Cl-), they\'re shared in a way such that they spend more time on one atom vs another (like CH3OH--the electrons spend more time on the O than they do on either the C or the Hs). How do you know which atoms like to hold onto electrons more than other atoms? Electronegativity differences. Certain atoms like F, N, and O are really electronegative, which means they like to hold onto electrons more than other atoms, like, say, C and H. So, if F were bound to C, the electrons would be on the F more often than the C. On the other hand, if you have to atoms, like C and H, which have very similar electronegativity values, they will share the electrons more readily, and the electrons don\'t stay on one or the other atoms more often. Such molecules are called non-polar, and are, in fact, not soluble in water. Instead, they\'re fat-soluble, because fat is just a whole bunch of C-H bonds next to each other. So, looking at the structures of those given vitamins, vitamin A consists mostly of a bunch of C-H bonds; it\'s likely fat soluble. Vi.