1. GraNdStudent Hears Calling to Share Science with YouthsAnd Antisense Therapy for Spinal Muscular Atrophy Shows PromisE GLORIA STHEFANY TORRES DAZA MEDICAL STUDENT 3° SEMESTER
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4. introduction The splicing is a modification of an RNA after transcription, in which introns are removed and exons are joined. The following news explains this important process, and gives a medical application.
5. Grad Student Hears Calling to Share Science with YouthsScience Daily (August 13, 2010) FIRST NEWS
6. Tuttle is a teacher in USA. She spent 10 weeks that summer studying the dynamics of the hepatitis D virus ribozyme, a virus that promotes development of the disease. More recently, she has been working on a project aimed at determining which metal atoms in the spliceosome are responsible for driving the chemistry of RNA molecules.
7. “The splicesome is a critical piece of machinery in the cells,” Tuttle explained. After DNA is transcribed into RNA, the spliceosome cuts that RNA at precise positions and re-stitches it back together in a new way. The transcripts need to be precisely spliced “because if you mess that up, you’re not going to be producing the correct gene products. And sure enough, splicing defects have been implicated in a number of human diseases.”
8. As an elementary school student, Tuttle thought science was all about answering multiple-choice questions from a textbook, not working with the yeast colonies, RNA molecules and X-ray films of her daily routine. A middle-school chemistry class changed all that. Now she feels drawn toward both research and science education. “I really loved teaching. It was fantastic to bring science to the new generation,” she said. For now, “I just want to do good science here and see where it takes me.”
9. Studentobservation: 1° news Thespliceosomeis a topicveryinterestingforthescinece and thestudentstoo. And themostimportantistheexamplethahTuttlegiveus, because, sheteachustostudywithdedicationthetopicsaboutthescience and lookingfortheutilitytothehumanity.
10. Antisense Therapy for Spinal Muscular Atrophy Shows PromiseScience Daily (July 12, 2010) SECOND NEWS
11. Scientists at Cold Spring Harbor Laboratory and California-based Isis Pharmaceuticals have succeeded in reversing symptoms of Type III SMA, a relatively mild form of the disease, in mice by introducing an ASO into their spinal cords. The ASO fixes the molecular mistake underlying SMA by redirecting a cellular editing process called alternative splicing.
12. SMA is caused by insufficient levels of a protein called Survival of Motor Neuron (SMN) in the spinal cord's motor neurons, which waste away along with the muscles that they can no longer control. The SMN1 gene, which produces the SMN protein, is missing or mutated beyond repair in SMA patients. Humans have a second SMN-producing gene called SMN2, but this gene is a poor backup, as it produces very little functional SMN protein. This deficiency stems from a mistake that occurs during splicing, a molecular editing process that kicks in after the gene's DNA has been copied into RNA.
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14. STUDENT OBSERVATION 2° NEWS In thisnewsthesciencetiststeam shows thewaytosavethepatientwith SMA, throughthealternativesplicing. Itis a veryimportantinvestigation, becausethe molecular biologyisthebasic of manyprocesswithmedicalutility, besidesthisprocceshelpstothemedicaladvances and the global healthtoo.
18. I THINK THAT THE SPLICING IS A VERY IMPORTANT PROCESS IN THE MOLECULAR BIOLOGY AND MEDICAL INVESTIGATIONS BECAUSE IT IS THE FUNDAMENTAL BASE TO CURE STRANGERS DISEASES AND IT GIVES DIFFERENT POSSIBILITIES OF ITS TREATMENT AND DIAGNOSTIC.
19. bibliography Grand Student Hears Calling Share Science with Younts. TheUniversity of Chicago News Office. URL: http://www.newswise.com/articles/grad-student-hears-calling-to-share-science-with-youths AntisenseTherapyforSpinal Muscular Antrophy Shows Promise. Science Daily. URL: http://www.sciencedaily.com/releases/2010/07/100712103501.htm MARTINES, S. LinaMaría. Biología Molecular. Quinta edición. Medellín 2009. P 142, 195. REVIEW ARTICLE. URL: http://www.bioline.org.br/pdf?hg06009 SPRINGERLINK. URL: http://www.springerlink.com/content/551x720542804742/
