The document discusses recent scientific findings related to DNA repair and gene expression regulation. It describes a study that linked epigenetic mechanisms controlling gene expression to bone and joint damage in ankylosing spondylitis. The study examined 75 patients over several years, finding that genes are not always expressed and require triggers to start expression processes. Maintaining high DNA methylation can also relate to non-expression of genes. Separately, it mentions the discovery of a "DNA ambulance" motor protein complex in yeast cells that repairs damaged DNA, though inaccurately and in a way that could lead to cancer. Researchers are working to better understand these DNA repair mechanisms and how genomic damage relates to disease progression and pathology.

1. Luis Daniel Uribe Montoya
ID: 000094455

4. The DNA repair allows
the cells to keep
producing proteins and
to replicate themself.
There are genes that not
always are being
expressed and requires
a trigger to start that
process.

5. MECHANISM REGULATING GENE EXPRESSION
LINKED TO BONE AND JOINT DAMAGE IN
ANKYLOSING SPONDYLITIS.
Influence of epigenetics on disease progression
(June 12, 2015)
MECHANISM REGULATING GENE
EXPRESSION LINKED TO BONE AND JOINT
DAMAGE IN ANKYLOSING SPONDYLITIS.

6. A high metilation state of
DNA is related with the non
expression of genes.
MECHANISM REGULATING GENE EXPRESSION LINKED TO
BONE AND JOINT DAMAGE IN ANKYLOSING SPONDYLITIS.

7. MECHANISM REGULATING GENE EXPRESSION LINKED TO
BONE AND JOINT DAMAGE IN ANKYLOSING SPONDYLITIS.
The study consisted of 75 AS
patients that had radiographs on
average every three years, with 35
of these patients exhibiting
radiographic progression.

8. MECHANISM REGULATING GENE EXPRESSION LINKED TO
BONE AND JOINT DAMAGE IN ANKYLOSING SPONDYLITIS.
INVESTIGATING
THE
MECHANISMS
THAT CONTROL
THESE CHANGES
COULD ONE DAY
LEAD TO
THERAPEUTIC
TARGETS FOR AS.

9. MECHANISM REGULATING GENE EXPRESSION LINKED TO
BONE AND JOINT DAMAGE IN ANKYLOSING SPONDYLITIS.
Student´s Observation:

10. SCIENTISTS DISCOVER FIRST 'DNA AMBULANCE'
(July 24, 2015)

11. The nuclear pore
complex, repairs
damaged DNA
inaccurately, which
could leads to
develop cancer.

12. The researchers
discovered this DNA
ambulance, which is a
motor protein complex,
by using yeast cells.

13. The
researchers team is
searching for more
DNA ambulances
and roads while
conducting a study
to see what role
they might play in
causing cancer.

16. THESE ADVANCES WILL LEAD
US TO A BETTER
UNDERSTANDING OF THE
HUMAN BODY PATOLOGY.

17. BEING ABLE TO RELATE
GENOMIC DAMAGE
WITH THE ADVANCE OF
A PATOLOGY WILL
EVENTUALLY GIVE US
THE CAPACITY TO
GENERATE NOT ONLY
A TREATMENT FOR IT
BUT A CURE.

18. THE TREATMENTS ARE
USUALLY USED WHEN A
DISEASE HAVE STARTED TO
DAMAGE OUR BODY BUT IF
DOCTORS CAN BEGIN THE
USE OF MEDICAMENTS TO
AVOID THE INITIAL DAMAGE
IT WILL BE LIKE THE
PHYLOSOPHER´S STONE FOR
OUR LIFES, GETTING AWAY
OF ILLNESS AND AGING.

19.  European League Against Rheumatism. (2015, June
12). Mechanism regulating gene expression linked to
bone and joint damage in ankylosing spondylitis:
Influence of epigenetics on disease
progression. ScienceDaily. Retrieved August 23, 2015
from
http://www.sciencedaily.com/releases/2015/06/150
612091828.htm
 University of Toronto. (2015, July 24). Scientists
discover first 'DNA ambulance'. ScienceDaily.
Retrieved August 23, 2015 from
http://www.sciencedaily.com/releases/2015/07/150
724081702.htm

20. ANGER AND
HATE IT'S
JUST A
HUMAN
PLAY