“New discovery reveals how RNA moves genetic
information from DNA to create proteins”
and
“Study offers new insights into ...
DNA replication is the
process in which a double
strand generated two
strands daughters .
RNA transcription is the
process...
“New discovery reveals how RNA
moves genetic information from DNA
to create proteins”
NEWS MEDICAL July 15, 2013
the RNA t...
NEWS MEDICAL July 15, 2013
RBFOX1, a controller gene
expression protein is a good
example of the power of
RNA control.
Thi...
NEWS MEDICAL July 15, 2013
RBFOX1 ensures the activity of
genes important for the
function of nerve cells in the
brain. Th...
The RBFOX1 detect patterns in RNA
molecules which are altered,
exercising a control to RNA
processing and movement.
This k...
STUDENT OBSERVATION
We are living on a proteomic century,
and I think is very interesting to look at
deeply into the mecha...
“Study offers new insights into how genome gets
regulated by signalling molecules within human
cells”
NEWS MEDICAL July 2,...
NEWS MEDICAL July 2, 2013
es.wikipedia.org -
Inositol phosphates are a group
of mono- to polyphosphorylated
inositols. The...
Histone Deacetylases (HDACs) are
enzymes that regulate the DNA
replication, HDACs causes the DNA to
become more tightly pa...
There is an inositol
phosphate-binding site at
the interface between the
HDACs and its corepressors
MTA1, for that reason
...
STUDENT OBSERVATION
Cancer research has still been target of
several scientific fields, I think is very
important to under...
Undoubtedly, the
answer to human
diseases is in the
cell Nucleus,
specifically at the
human genome
jairjaramillo.blogspot.com
www.amancchihuahua.orgwww.taringa.net
cancer and autism are two diseases that present
alteratio...
Understanding the interactions of proteins that
control replication and transcription will allow
developing new drugs and ...
Misunderstood
diseases will be
studied based on the
proteins that control
genes
BIBLIOGRAPHY
Martínez S, Lina María. Biología Molecular. 7 ed. Medellín: UPB. Facultad de
Medicina, 2012. 74,,85,89. P
Sch...
¡THANKS!
Plegable biología molecular
Plegable biología molecular
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Plegable biología molecular

  1. 1. “New discovery reveals how RNA moves genetic information from DNA to create proteins” and “Study offers new insights into how genome gets regulated by signalling molecules within human cells” Sara Puche Gómez Medicine student III semester MOLECULAR BIOLOGY antoniopelaezchillon.blogspot.com
  2. 2. DNA replication is the process in which a double strand generated two strands daughters . RNA transcription is the process in which a segment of DNA is copied into RNAm this results in a RNA complement that includes uracil (U) in all instances where thymine (T) would have occurred in a DNA complement. Then it will be used to create proteins Both investigations focused their attention on the “control code” of these two vital processes to find possible causes of diseases like cancer or autism.
  3. 3. “New discovery reveals how RNA moves genetic information from DNA to create proteins” NEWS MEDICAL July 15, 2013 the RNA transcription is regulated by proteins as ADN replication, this fact led to scientists to research more about the RNA “control code” because many human diseases are due to defects on it.
  4. 4. NEWS MEDICAL July 15, 2013 RBFOX1, a controller gene expression protein is a good example of the power of RNA control. This protein also stabilizes RNA www.bioinformatics.org
  5. 5. NEWS MEDICAL July 15, 2013 RBFOX1 ensures the activity of genes important for the function of nerve cells in the brain. The protein is turn off in the brains of patients with autism. www.eluniversal.com.co
  6. 6. The RBFOX1 detect patterns in RNA molecules which are altered, exercising a control to RNA processing and movement. This knowledge is essential to develop new treatment for autism and another diseases NEWS MEDICAL July 15, 2013 es.wikipedia.org -
  7. 7. STUDENT OBSERVATION We are living on a proteomic century, and I think is very interesting to look at deeply into the mechanism of RNA transcription, because, proteins that control this process have the answer to several misunderstood diseases, besides I think our government should invest much money on these kind of researches www.urosario.edu.co
  8. 8. “Study offers new insights into how genome gets regulated by signalling molecules within human cells” NEWS MEDICAL July 2, 2013 The DNA replication is regulated by enzymes as the RNA transcription in a very similar way. But in the first case a family of complexes switch off gene expression, and they in turn are regulated by small signalling molecules called inositol phosphates.
  9. 9. NEWS MEDICAL July 2, 2013 es.wikipedia.org - Inositol phosphates are a group of mono- to polyphosphorylated inositols. They play crucial roles in diverse cellular functions such as:  cell growth  apoptosis  cell migration  endocytosis  cell differentiation
  10. 10. Histone Deacetylases (HDACs) are enzymes that regulate the DNA replication, HDACs causes the DNA to become more tightly packaged and genes switches off by making them unavailable for expression. HDACs are recruited to DNA by corepressors (MTA1 - Metastasis-associated protein 1 )that target the enzyme to the correct gene. .
  11. 11. There is an inositol phosphate-binding site at the interface between the HDACs and its corepressors MTA1, for that reason inositol phosphates are thought as the key regulator throughout this class of enzyme.
  12. 12. STUDENT OBSERVATION Cancer research has still been target of several scientific fields, I think is very important to understad how the proteins interact at the atomic level to improve cancer treatment, after all medicine every time is more and more molecular. As a medicine student is essential to see the life since the basic principle: the genome. www.urosario.edu.co
  13. 13. Undoubtedly, the answer to human diseases is in the cell Nucleus, specifically at the human genome
  14. 14. jairjaramillo.blogspot.com www.amancchihuahua.orgwww.taringa.net cancer and autism are two diseases that present alteration in the DNA or RNA “control code”, that’s why it is important studing the regulators mechanisms of genetic expression
  15. 15. Understanding the interactions of proteins that control replication and transcription will allow developing new drugs and treatments to combat several diseases blogingenieria.com MEDICAL UTILITY
  16. 16. Misunderstood diseases will be studied based on the proteins that control genes
  17. 17. BIBLIOGRAPHY Martínez S, Lina María. Biología Molecular. 7 ed. Medellín: UPB. Facultad de Medicina, 2012. 74,,85,89. P Schwabe, John. Study offers new insights into how genome gets regulated by signalling molecules within human cells. News medical, (online magazine),2013(July2). available online: http://www.news- medical.net/news/20130702/Study-offers-new-insights-into-how-genome-gets- regulated-by-signalling-molecules-within-human cells. aspx. Morris, Quaid. Ray, Debashish. Kazan, Hilal. Hughes, Tim. New discovery reveals how RNA moves genetic information from DNA to create proteins. News medical, (online magazine), 2013(July15) available online: http://www.news- medical.net/news/20130715/New-discovery-reveals-how-RNA-moves-genetic- information-from-DNA-to-create-proteins.aspx
  18. 18. ¡THANKS!

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