The student attended three seminars on different topics that helped them define their interest in scientific investigation. The first seminar discussed neurotrophic factor biodynamics in animal disease models. The second presented new treatments for epilepsy using pluripotent cells. The third introduced techniques for melting and analyzing crystals using thermo gravimetric analysis, differential thermal analysis, and mass spectrometry. Attending these seminars exposed the student to current research themes and motivated them to learn more about areas that piqued their interest.
Professor Peter Gunning, Associate Dean (Research), UNSW Medicine, Editor-In-Chief, BioArchitecture
President, ASBMB; Head, Oncology Research Unit,
School of Medical Sciences, UNSW. http://www.garvan.org.au/news-events/leaders-in-science-and-society
Controversy - The Cause of Alzheimer's / By Michael MullanMichael Mullan
A recent paper by a huge international collaborative group of researchers has re-fired the controversy over what really causes Alzheimer's disease. An article written by Dr. Michael Mullan, an Alzheimer's researcher.
Read more...
Patrik Brundin - Are Synucleinopathies Prion Diseases?Alzforum
Presentation made April 8, 2016 at the live webinar hosted by Alzforum - http://www.alzforum.org/webinars/webinar-pathogenic-protein-spread-lets-think-again
Professor Peter Gunning, Associate Dean (Research), UNSW Medicine, Editor-In-Chief, BioArchitecture
President, ASBMB; Head, Oncology Research Unit,
School of Medical Sciences, UNSW. http://www.garvan.org.au/news-events/leaders-in-science-and-society
Controversy - The Cause of Alzheimer's / By Michael MullanMichael Mullan
A recent paper by a huge international collaborative group of researchers has re-fired the controversy over what really causes Alzheimer's disease. An article written by Dr. Michael Mullan, an Alzheimer's researcher.
Read more...
Patrik Brundin - Are Synucleinopathies Prion Diseases?Alzforum
Presentation made April 8, 2016 at the live webinar hosted by Alzforum - http://www.alzforum.org/webinars/webinar-pathogenic-protein-spread-lets-think-again
Eat less, live longer cutting back on food can help repair the body by Dr.Ma...Healthcare consultant
Eating less can boost healthier ageing by protecting the body’s cells from harmful deterioration and the risk of cancer.
Scientists know an extreme diet does not appeal to many people but say their discovery could lead to ways of mimicking its effects and pave the way for an “anti-ageing pill.
Cell lineage trees and the limiting problem of comprehensive rejuvenationattilacsordas
Edited version of the slides of the talk given by AgeCurve CEO/Founder Attila Csordas on 20190912 in Longevity - How Humans Will Live Longer and Prosper event in Mayfair, London.
A Mechanistic, Stochastic Model Helps Understand Multiple Sclerosis Course an...Mutiple Sclerosis
Isabella Bordi, Renato Umeton, Vito A. G. Ricigliano, Viviana Annibali, Rosella Mechelli, Giovanni Ristori, Francesca Grassi, Marco Salvetti, and Alfonso Sutera
Heritable and nonheritable factors play a role in multiple sclerosis, but their effect size appears too small, explaining relatively little about disease etiology. Assuming that the factors that trigger the onset of the disease are, to some extent, also those that generate its remissions and relapses, we attempted to model the erratic behaviour of the disease course as observed on a dataset containing the time series of relapses and remissions of 70 patients free of disease-modifying therapies. We show that relapses and remissions follow exponential decaying distributions, excluding periodic recurrences and confirming that relapses manifest randomly in time. It is found that a mechanistic model with a random forcing describes in a satisfactory manner the occurrence of relapses and remissions, and the differences in the length of time spent in each one of the two states. This model may describe how interactions between "soft" etiologic factors occasionally reach the disease threshold thanks to comparably small external random perturbations. The model offers a new context to rethink key problems such as "missing heritability" and "hidden environmental structure" in the etiology of complex traits.
Biology, genetics, nanotechnology, neuroscience, materials science, biotech, ...Brian Russell
Over the past two years I've done a lot of interesting research which I've decided to aggregate. My research pertains to the following: Biology, Genetics, Nanotechnology, Neuroscience, Materials Science, Biotechnology, Chemical Engineering, All Things 3-D, Super Computing, Quantum Physics, Energy, Design, & Sustainability.
It´s a workshop about medical genetics where you would find two news that are related to medicine, biology and genetics, there are some opinions from a medicine student about them to explain how important was each research
Eat less, live longer cutting back on food can help repair the body by Dr.Ma...Healthcare consultant
Eating less can boost healthier ageing by protecting the body’s cells from harmful deterioration and the risk of cancer.
Scientists know an extreme diet does not appeal to many people but say their discovery could lead to ways of mimicking its effects and pave the way for an “anti-ageing pill.
Cell lineage trees and the limiting problem of comprehensive rejuvenationattilacsordas
Edited version of the slides of the talk given by AgeCurve CEO/Founder Attila Csordas on 20190912 in Longevity - How Humans Will Live Longer and Prosper event in Mayfair, London.
A Mechanistic, Stochastic Model Helps Understand Multiple Sclerosis Course an...Mutiple Sclerosis
Isabella Bordi, Renato Umeton, Vito A. G. Ricigliano, Viviana Annibali, Rosella Mechelli, Giovanni Ristori, Francesca Grassi, Marco Salvetti, and Alfonso Sutera
Heritable and nonheritable factors play a role in multiple sclerosis, but their effect size appears too small, explaining relatively little about disease etiology. Assuming that the factors that trigger the onset of the disease are, to some extent, also those that generate its remissions and relapses, we attempted to model the erratic behaviour of the disease course as observed on a dataset containing the time series of relapses and remissions of 70 patients free of disease-modifying therapies. We show that relapses and remissions follow exponential decaying distributions, excluding periodic recurrences and confirming that relapses manifest randomly in time. It is found that a mechanistic model with a random forcing describes in a satisfactory manner the occurrence of relapses and remissions, and the differences in the length of time spent in each one of the two states. This model may describe how interactions between "soft" etiologic factors occasionally reach the disease threshold thanks to comparably small external random perturbations. The model offers a new context to rethink key problems such as "missing heritability" and "hidden environmental structure" in the etiology of complex traits.
Biology, genetics, nanotechnology, neuroscience, materials science, biotech, ...Brian Russell
Over the past two years I've done a lot of interesting research which I've decided to aggregate. My research pertains to the following: Biology, Genetics, Nanotechnology, Neuroscience, Materials Science, Biotechnology, Chemical Engineering, All Things 3-D, Super Computing, Quantum Physics, Energy, Design, & Sustainability.
It´s a workshop about medical genetics where you would find two news that are related to medicine, biology and genetics, there are some opinions from a medicine student about them to explain how important was each research
Wagner College Forum for Undergraduate Research, Vol. 18 No. 1Wagner College
The Fall 2019 issue contains abstracts by Briana Bettencourt, Nicholas Buhta, Alexis Costa, Joseph Fabozzi, Sarah McGee, Kayla Diggs, Elizabeth Patton, Kelsey Savje, Oskar Sundberg and Kaela Teele. It also contains articles by Maria Humphries, Kathleen Leavey, Angela Zagami, Lindy Pokorny and L. Elise Whisler.
The Growth Of New Brain Cells: Researchers Find A Way To "Hack" Neurons' Inte...The Lifesciences Magazine
The sluggish pace makes it difficult for the growth of new brain cells in the lab for research on neurodegenerative and neurodevelopmental disorders, such as autism, Parkinson's disease, and Alzheimer's disease
Stem Cell ResearchStem cells are cells that can grow and differe.docxwhitneyleman54422
Stem Cell Research
Stem cells are cells that can grow and differentiate into other types of cells. These cells have great potential for the treatment of various disorders such as cancer or Parkinson’s disease where the body cannot regenerate healthy cells to cure the disease. Stem cell research has been going on for a long time, and there have been great breakthroughs in the research. One such breakthrough has been the use of stem cells in the rejuvenation of neural cells of monkeys suffering from Parkinson’s disease. Scientists have used induced pluripotent cells to form some types of brain cells that have been damaged by the disease. Parkinson’s disease is caused by the degeneration of specific brain cells that control motor functions and mood. Researchers have previously been able to restore motor functions in rats that have shown characteristic symptoms of Parkinson’s disease by using dopamine neurotransmitters grown from human induced pluripotent cells. In spite of this, there has not been any investigation on the long-term effects of the use of this practice on the primates.
Researchers from California have demonstrated that injecting stem cells taken from the hearts of newborn rats into older rats improved the latter’s cardiovascular function and capacity.
A study done by Jun Takahashi was done to evaluate the safety and applicability of the practice in primates. Human induced pluripotent cells were used to generate dopamine neurons which were transplanted into primates that had been induced to have the Parkinson’s disease. The primates showed increasing spontaneous increase in the motor cells after transplantation and complete functioning in the midbrain. There was no long-term effect of the cells on the primates after two years since no brain tumors were observed (Sandoiu, 2017). This information is critical as it has opened a gateway to the treatment of Parkinson’s disease. The study shows that once more research is done this could be a method to treat people suffering from the disease and will help to relieve human suffering. The study has unlocked one of the many possibilities of the use of stem cell research and will, therefore, earn it more favor and support from the public.
Human neural stem cells are derived via fluorescence-activated cell sorting (FACS) from donated fetal brain tissue.
A study was done on mice by Hai Nguyen, Aileen Anderson and colleagues found that mice receiving stem cells grown from human brain tissue required the depletion of some types of immune cells to improve the motor skills of the mice. The donor cells survived equally when transplanted either immediately or after a month after the injury. Their location however continuously changed and this suggested that the cells were populating the spinal cord at different times after the injury and it affected the ability of the transplants to provide functional recovery of the motor skills (Society for Neuroscience. 2017). This means that the stem cells could .
1. Seminar Essay <br />RISE Program<br />Cristina M. Cruz Irizarry<br />During this semester I got the opportunity to attend three seminars. Each addresses different topics of investigation. This is very helpful for us students, because we get the opportunity to see and take in the themes that are now been investigated. Hearing the seminars is an important aspect that encourages us to be more attracted to certain themes than others; with the purpose of finding our topic of interest in the scientific investigation world. The three seminars that help me define my interest were: Neurotrophic Factor Biodynamic in Animal Models with Diseases, given by Dr. John Spitsbergen; New Techniques for Melting and Analysis of Crystals, by Dr. Andrew McGie; finally New Treatment for Epilepsy Disease, by Lori Isom.<br />The seminar that covers the Neurotrophic Factor Biodynamic in Animal Models of Diseases was a very interesting one. It was given by Dr. John Spitsbergen, he came in representation of the North Michigan University. This study specifies in the relationship between diseases and neurotrophic factors. Neuritrophic factors are proteins that are in charge of the development and maintenance of neurons. Their hypothesis is that the effects of some diseases in the body are dependent on the effects that the disease have to the nuerotrophic factor. To test their hypothesis they use rats that had high blood pressure. After giving the rats a diet high in sodium to maintain their condition of hypertension, it could be observed that whenever there was a change in blood pressure there was a change too in the nuerotrphic responses. The hypothesis came correct; this will promote the study of neurotrhophic factors in the battle against diseases.<br />The seminar given by Lori Isom was related to the new treatments that have been develop for the epilepsy disease. The condition denominated as epilepsy can be very degenerating to the body motor capacities. Epilepsy is a brain condition that is cause when involuntary electric signals in the brain causes convulsations. This convulsations are very dangerous because they interrupt the normal function of the brain. Avery time a patient has a convulsion many cells are damaged. Researchers are looking for a way to restore these cells. They discovered that by allowing the production of pluripotent cells, this damage cells can be replaced. This happens because the pluripotent cells can take any form of cell. These cells are very benefactor to the maintenance of the health of patients with conditions like epilepsy. <br />Last seminar called New Melt Crystallization Techniques for Purification and Analysis Of Organics and Pharmaceutical, presented by Andrew McGie from the University of Pennsylvania. He presents three basic techniques for the analysis and melting of crystals. The first technique offered was Thermo Gravimetric Analysis (TGA). This technique consists of measuring the weigh change amounts of the crystal in function of increasing temperature. The second technique was differential thermal analysis (DTA). This one consisted in the examination of the changes in the basic structure of the crystal during temperature changes. Then the affected structure is compare with the normal structure for the analysis of the changes in structure of the structure. The final technique is known as mass spectrometry (MS) it consist of introducing a charge to the crystal, this helps to identify the mass charge ratio depending on the reaction of the crystal to the charge. <br />In conclusion, each one of the seminars is very rewarding to the scientific community. As part of this community it is very important to be informed of the latest discoveries in science. Knowing about this topic brings opportunities of work to the new scientist, it is important to read and maintain fresh information. Day by day we are forming what we want to be in the future the seminars are a great motivation for keeping us in track.<br /> <br />