Orthogonal Frequency Division Multiple Access (OFDMA) is a multiple access technique that uses OFDM and FDMA. It divides the available bandwidth into multiple orthogonal subcarriers, assigning subsets of subcarriers to individual users. This allows for efficient use of spectrum and multi-user diversity. OFDMA provides better performance in fading environments compared to CDMA. However, it suffers from high peak-to-average power ratio and requires tight synchronization between users. OFDMA is used in wireless standards like WiMax due to its ability to support high data rates and combat intersymbol interference.