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Textbook of
Human
Embryology
with Clinical Cases and 3D Illustrations
Dr Yogesh Sontakke
Associate Professor,
Department of Anatomy,
JIPMER, Pondicherry 605006
Features of the book
 Concise text is given in easy language for quick recapitulation during examination.
 3D illustrations to provide easy imagining of embryological changes.
 Flowchart to revise and memorise the developmental sequence.
 Tables to summarise that essential facts.
 Summary (examination guide): To overcome the difficulty of summarising the facts in theory examinations.
 Neet, MCQ, Viva and Clinical facts markings: For preparation of various upcoming academic entrance examinations.
 Boxes: To focus on important topics.
 Interesting facts: To isolate them from main text, so that these facts should not be missed.
 40 Scanning electron micrographs: to give real insight in developing structures.
 70 Clinical cases: For early clinical exposure of various clinical anomalies encountered by eminent clinicians.
 Practice figures: Easy to draw figures in theory examination.
3D illustrations to provide
easy imagining of
embryological changes.
• Most of the figures are 3D
illustrations that resembles
original human organs and
hence give idea about original
human structures
Flowchart to revise and memorise the
developmental sequence.
• More than 50 flowcharts are given
• Flowchart uses:
• Easy to remember
• Easy to revise: decreases the revision time drastically
• Helpful in theory examinations
• Gives idea of sequential development in embryology
Flowchart 4.2: Formation of blastocyst. Flowchart 11.3: Development of the palatine tonsil
Flowchart 20.2: Development of kidney. Figure 21.1: Sex differentiation in male.
Tables to summarise that essential facts.
• In each chapter, small tables are included to summarise the facts
• Uses of these tables:
• To summarise the facts
• Decreases the revision time drastically
• Helpful in theory examinations: if student write only the tabulated facts,
rather than lengthy writeups
Part of liver Embryonic source
Lobes of liver
- Liver parenchyma
- Bile canaliculi
- Bile ductules
Endoderm: hepatic bud
arising from the second
part of the duodenum
(that develops from
foregut)
Connective tissue
- Glisson’s capsule
- Connective tissue stroma
- Kupffer’s cells
- Blood vessels
Mesoderm: septum
transversum
Liver sinusoids Vitelline and umbilical
veins
Ligaments of liver
- Falciform ligament
- Lesser omentum
- Coronary ligaments
- Triangular ligaments
Ventral mesogastrium
Ligamentum teres hepatis Left umbilical vein
Ligamentum venosum Ductus venosus
Table 15.1: Development of liver.
Part of diaphragm Embryonic source
Central tendon Septum transversum
Small peripheral part Pleuro-peritoneal membranes
Large peripheral part
(posterolateral)
Mesoderm of lateral body wall
Right and left crus Dorsal mesentery of
oesophagus
Table 17.1: Development of diaphragm
Summary (examination guide): To overcome the
difficulty of summarising the facts in theory examinations.
• Uses of Summary (examination guide):
• Given in many places to summarise the lengthy descriptions
• To avoid the confusion of student about ‘What to write in the
examination’
• Decreases the revision time drastically
Example from Chapter 18:
Formation of Interventricular Septum
Q. Write short note on development of interventricular septum.
Summary (examination guide)
 Interventricular part consists of three parts:
- Muscular part: develops from muscular ridge arising on the floor of primitive
ventricle.
- Bulbar part: develops from right and left bulbar ridges arising from conus cordis.
- Membranous part: develops from proliferation of AV cushion that fills the gap
between muscular and bulbar parts.
Neet, MCQ, Viva and Clinical facts markings: For preparation of
various upcoming academic entrance examinations.
• The markings on important lines are given that may
be useful for
• Neet: National Eligibility cum Entrance Test
• MCQ: multiple choice questions
• Viva: for oral examination
• Clinical facts: For indicating the points that will have
clinical applications
Box 2.1:Teratoma
Teratoma
 Teratoma is a tumour that consists of
tissues derived from all germ layers
 Sacrococcygeal teratoma is the most
common tumour in newborns (1 in
20,000–70, 000 births). It arises from
primordial germ cells.Neet
 It occurs more frequently in females than
in males.
 It constitutes 3% of childhood
malignancies.
 ……… Continued…
Box 16.1:Tracheoesophageal fistula
Q: Write short note on
tracheoesophageal fistula
 Definition: Tracheoesophageal fistula is an abnormal
congenital communication between the trachea and
oesophagus.
 Incidence: 1:3000-4500 births.
 Causes
Right and left tracheoesophageal folds on fusion forms
tracheoesophageal septum that separates the trachea
from the oesophagus. Failure of fusion of
tracheoesophageal septum results in TEF.
 Types (Figure 16.4)
……….Continued…
Boxes: To focus on important topics.
• Separate boxes are given to cover important topics, clinical conditions and so
on
Interesting facts: To isolate them from main
text, so that these facts should not be missed.
• These important and interesting points are isolated from main text to
attract attention of the reader
Some interesting facts
 Spermatozoa are artificially capacitated and
used for in vitro fertilisation (IVF).
 In assisted reproduction technology (ART) for
a patient with defective acrosome, sperm is
injected directly into oocyte.
 Sperm with Y chromosome swims faster dur
to smaller size of Y chromosome.Neet
 Sperms are stored in seminiferous tubules
after formation.Neet
Chapter 2
Some interesting facts
Nitabuch’s membrane
 Nitabuch’s membrane is the fibrinoid deposition over
the outer cytotrophoblast shell. It makes a demarcation
between maternal and foetal tissue.
Rohr’s Fibrinoid stria
 Rohr’s fibrinoid stria is the fibrinoid deposition on the
intervillous surface of the syncytiotrophoblast. It was
first described by Wolska (1888).
 These membranes play a major role is an
immunological separation of foetal tissue from
maternal tissue.
Foetal cotyledons
 Chorionic plate shows 40–60 extensions that extend
towards decidua basalis. ………
Langhans layer
 Cytotrophoblast layer is also called Langhans layer.
…….
Chapter 9
40 Scanning electron micrographs: to
give real insight in developing structures.
Scanning electron micrograph 8.1:
SEM showing embryo at 25th days with
closing anterior neuropore. [Species:
mouse, approximate human age: 25
days, frontolateral view].
Scanning electron micrograph 11.1: SEM showing
pharyngeal arches. On twenty seventh day (by the time
that anterior neuropore closes), the first and second
pharyngeal arches are evident. [Species: mouse,
approximate human age: 27 days, lateral view].
70 Clinical cases: For early clinical exposure
of various clinical anomalies encountered by
eminent clinicians.
• 70 clinical cases are described with proper explanations, labelling,
and belong to Indian population
• It will stimulate the insight of the student to see these cases in the
classes of Early Clinical exposures
Clinical image 30.2: Conjoined twins: Thoracopagus
Clinical image 21.4: Perineal Hypospadias
Clinical image 10.3: Harlequin ichthyosis. Clinical Image 11.1. A. Unilateral branchial
cleft cyst (right). B. Excised branchial cyst
from the same case.
Practice figures: Easy to draw figures in
theory examination.
• Specially given to help the student for theory exam preparation
• After understanding 3D images, few important line diagrams are given
for the student to replicate the in the theory examination
Figure 2.9: Ovum
Practice figure 2.3: Structure of ovum.
Difficult to draw
Easy to draw
Practice figure 8.1: Head
and tail folds of embryo
Figure 8.7: Formation of craniocaudal
(head and tail) foldings of the embryo.
Difficult to draw
Easy to draw
Figure 11.9: Derivatives of the pharyngeal pouches.
Practice figure 11.2: Derivatives
of the pharyngeal pouches
Difficult to draw
Give more idea about reality
Easy to draw
Do not give idea about reality
Additional topics/chapters
• Special chapters on:
• Chapter 3: Menstrual cycle
• Chapter 5: Assisted reproductive techniques (includes IVF)
• Chapter 10 : Integumentary system: Skin and its appendages
• Chapter 11: pharyngeal apparatus
• Chapter 26: Skeletal system
• Chapter 27: Muscular system
• Chapter 29: Clinical applications and ultrasonography in embryology
• Chapter 30: Twins
Some Images from book
Figure 2.2: Process of
spermatogenesis.
Figure 2.4: Structure of sperm.
Some Images from Yogesh’s Embryology
Figure 3.2: Layers of uterine endometrium
during proliferative phase of the menstrual
cycle, and blood supply of endometrium
Figure 4.3: Fertilisation. Phase of sperm penetration through
coverings of the ovum
Some Images from Yogesh’s Embryology
Figure 4.7: Blastocyst. Differentiation
of inner cell mass into epiblast and
hypoblast. Figure 6.2: Day 9 embryo. Formation of trophoblastic lacunae.
Some Images from Yogesh’s Embryology
Figure 6.6: Day 13: Development of extraembryonic coelom and
formation of secondary yolk sac.
Figure 8.2: Embryo by day 24: side view
Some Images from Yogesh’s Embryology
Figure 8.11: Sagittal section of the embryo
showing the derivatives of the endoderm.
Figure 10.2: Development of hair. Shaft of hair follicle
develops form surface ectoderm
Some Images from Yogesh’s Embryology
Figure 11.11: Anomalies of the position of the
thyroid gland and locations of the thyroglossal cyst
Figure 12.4:
Development of
the palate
Figure 14.4: Transverse
section through the region
of the stomach showing the
changes in the position of
stomach, liver and spleen.
Figure 14.12:
Development of
the anal canal.
Figure 17.3: Separations of the pericardial, pleural and
peritoneal cavities from each other.
Scanning electron micrograph 18.3: Heart chambers
and outflow tract.
Figure 18.15: Tetralogy of Fallot.
Figure 18.8: Development of interatrial septum.
Figure 19.3: Relation of the pharyngeal arch arteries with
foregut
Figure 19.11: Cross section of the embryo showing major
embryonic veins.
Figure 20.3: A 28 days foetus showing pronephros,
mesonephros and metaneprhos.
Figure 21.6:
Anomalies of
processus vaginalis. A.
Hydrocoele. B.
Encysted hydrocoele.
C. Hydrocoele with
congenital inguinal
hernia.
Figure 22.4: Development of
spinal cord.
Figure 22.7: Developing spinal cord – positional changes
Figure 22.16: A: In 8-week
embryo, section showing
medial surface of the right
half of the telencephalon
and diencephalon (red
broken line indicates the
plane of the section for B,
C and D).
Figure 22.18: Formation of commissures of telencephalon at 10 weeks (A) and 16 weeks (B). For integration of the activity of
right and left cerebral hemispheres, commissures play a key role.
Figure 22.1: Fully developed eyeball. Figure 23.3: Further development of eyeball (Day 29 and 33).
Figure 24.3: Development
of membranous labyrinth.
Figure 25.3: Cross section of embryo showing developing
adrenal gland Figure 27.3: Myotomes
Figure 26.3: Endochondral ossification (development of long bone)
About author: Dr Yogesh Sontakke
MBBS, MD (Anatomy)
• Currently working as Associate professor (Anatomy) at Jawaharlal
Institute of Postgraduate Medical Education & Research (JIPMER)
(An Institution of National Importance under the Ministry of Health &
Family Welfare, Government of India), Pondicherry.
• He also author other books:
1. Principles of Histological Techniques, Immunohistochemistry and
Microscopy
2. Principles of Clinical Genetics
3. Principles of Scientific writing

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Features of human embryology by dr yogesh

  • 1. Textbook of Human Embryology with Clinical Cases and 3D Illustrations Dr Yogesh Sontakke Associate Professor, Department of Anatomy, JIPMER, Pondicherry 605006
  • 2. Features of the book  Concise text is given in easy language for quick recapitulation during examination.  3D illustrations to provide easy imagining of embryological changes.  Flowchart to revise and memorise the developmental sequence.  Tables to summarise that essential facts.  Summary (examination guide): To overcome the difficulty of summarising the facts in theory examinations.  Neet, MCQ, Viva and Clinical facts markings: For preparation of various upcoming academic entrance examinations.  Boxes: To focus on important topics.  Interesting facts: To isolate them from main text, so that these facts should not be missed.  40 Scanning electron micrographs: to give real insight in developing structures.  70 Clinical cases: For early clinical exposure of various clinical anomalies encountered by eminent clinicians.  Practice figures: Easy to draw figures in theory examination.
  • 3. 3D illustrations to provide easy imagining of embryological changes. • Most of the figures are 3D illustrations that resembles original human organs and hence give idea about original human structures
  • 4.
  • 5. Flowchart to revise and memorise the developmental sequence. • More than 50 flowcharts are given • Flowchart uses: • Easy to remember • Easy to revise: decreases the revision time drastically • Helpful in theory examinations • Gives idea of sequential development in embryology
  • 6. Flowchart 4.2: Formation of blastocyst. Flowchart 11.3: Development of the palatine tonsil
  • 7. Flowchart 20.2: Development of kidney. Figure 21.1: Sex differentiation in male.
  • 8. Tables to summarise that essential facts. • In each chapter, small tables are included to summarise the facts • Uses of these tables: • To summarise the facts • Decreases the revision time drastically • Helpful in theory examinations: if student write only the tabulated facts, rather than lengthy writeups
  • 9. Part of liver Embryonic source Lobes of liver - Liver parenchyma - Bile canaliculi - Bile ductules Endoderm: hepatic bud arising from the second part of the duodenum (that develops from foregut) Connective tissue - Glisson’s capsule - Connective tissue stroma - Kupffer’s cells - Blood vessels Mesoderm: septum transversum Liver sinusoids Vitelline and umbilical veins Ligaments of liver - Falciform ligament - Lesser omentum - Coronary ligaments - Triangular ligaments Ventral mesogastrium Ligamentum teres hepatis Left umbilical vein Ligamentum venosum Ductus venosus Table 15.1: Development of liver. Part of diaphragm Embryonic source Central tendon Septum transversum Small peripheral part Pleuro-peritoneal membranes Large peripheral part (posterolateral) Mesoderm of lateral body wall Right and left crus Dorsal mesentery of oesophagus Table 17.1: Development of diaphragm
  • 10. Summary (examination guide): To overcome the difficulty of summarising the facts in theory examinations. • Uses of Summary (examination guide): • Given in many places to summarise the lengthy descriptions • To avoid the confusion of student about ‘What to write in the examination’ • Decreases the revision time drastically
  • 11. Example from Chapter 18: Formation of Interventricular Septum Q. Write short note on development of interventricular septum. Summary (examination guide)  Interventricular part consists of three parts: - Muscular part: develops from muscular ridge arising on the floor of primitive ventricle. - Bulbar part: develops from right and left bulbar ridges arising from conus cordis. - Membranous part: develops from proliferation of AV cushion that fills the gap between muscular and bulbar parts.
  • 12. Neet, MCQ, Viva and Clinical facts markings: For preparation of various upcoming academic entrance examinations. • The markings on important lines are given that may be useful for • Neet: National Eligibility cum Entrance Test • MCQ: multiple choice questions • Viva: for oral examination • Clinical facts: For indicating the points that will have clinical applications
  • 13. Box 2.1:Teratoma Teratoma  Teratoma is a tumour that consists of tissues derived from all germ layers  Sacrococcygeal teratoma is the most common tumour in newborns (1 in 20,000–70, 000 births). It arises from primordial germ cells.Neet  It occurs more frequently in females than in males.  It constitutes 3% of childhood malignancies.  ……… Continued… Box 16.1:Tracheoesophageal fistula Q: Write short note on tracheoesophageal fistula  Definition: Tracheoesophageal fistula is an abnormal congenital communication between the trachea and oesophagus.  Incidence: 1:3000-4500 births.  Causes Right and left tracheoesophageal folds on fusion forms tracheoesophageal septum that separates the trachea from the oesophagus. Failure of fusion of tracheoesophageal septum results in TEF.  Types (Figure 16.4) ……….Continued… Boxes: To focus on important topics. • Separate boxes are given to cover important topics, clinical conditions and so on
  • 14. Interesting facts: To isolate them from main text, so that these facts should not be missed. • These important and interesting points are isolated from main text to attract attention of the reader
  • 15. Some interesting facts  Spermatozoa are artificially capacitated and used for in vitro fertilisation (IVF).  In assisted reproduction technology (ART) for a patient with defective acrosome, sperm is injected directly into oocyte.  Sperm with Y chromosome swims faster dur to smaller size of Y chromosome.Neet  Sperms are stored in seminiferous tubules after formation.Neet Chapter 2 Some interesting facts Nitabuch’s membrane  Nitabuch’s membrane is the fibrinoid deposition over the outer cytotrophoblast shell. It makes a demarcation between maternal and foetal tissue. Rohr’s Fibrinoid stria  Rohr’s fibrinoid stria is the fibrinoid deposition on the intervillous surface of the syncytiotrophoblast. It was first described by Wolska (1888).  These membranes play a major role is an immunological separation of foetal tissue from maternal tissue. Foetal cotyledons  Chorionic plate shows 40–60 extensions that extend towards decidua basalis. ……… Langhans layer  Cytotrophoblast layer is also called Langhans layer. ……. Chapter 9
  • 16. 40 Scanning electron micrographs: to give real insight in developing structures. Scanning electron micrograph 8.1: SEM showing embryo at 25th days with closing anterior neuropore. [Species: mouse, approximate human age: 25 days, frontolateral view]. Scanning electron micrograph 11.1: SEM showing pharyngeal arches. On twenty seventh day (by the time that anterior neuropore closes), the first and second pharyngeal arches are evident. [Species: mouse, approximate human age: 27 days, lateral view].
  • 17. 70 Clinical cases: For early clinical exposure of various clinical anomalies encountered by eminent clinicians. • 70 clinical cases are described with proper explanations, labelling, and belong to Indian population • It will stimulate the insight of the student to see these cases in the classes of Early Clinical exposures
  • 18. Clinical image 30.2: Conjoined twins: Thoracopagus Clinical image 21.4: Perineal Hypospadias
  • 19. Clinical image 10.3: Harlequin ichthyosis. Clinical Image 11.1. A. Unilateral branchial cleft cyst (right). B. Excised branchial cyst from the same case.
  • 20. Practice figures: Easy to draw figures in theory examination. • Specially given to help the student for theory exam preparation • After understanding 3D images, few important line diagrams are given for the student to replicate the in the theory examination
  • 21. Figure 2.9: Ovum Practice figure 2.3: Structure of ovum. Difficult to draw Easy to draw
  • 22. Practice figure 8.1: Head and tail folds of embryo Figure 8.7: Formation of craniocaudal (head and tail) foldings of the embryo. Difficult to draw Easy to draw
  • 23. Figure 11.9: Derivatives of the pharyngeal pouches. Practice figure 11.2: Derivatives of the pharyngeal pouches Difficult to draw Give more idea about reality Easy to draw Do not give idea about reality
  • 24. Additional topics/chapters • Special chapters on: • Chapter 3: Menstrual cycle • Chapter 5: Assisted reproductive techniques (includes IVF) • Chapter 10 : Integumentary system: Skin and its appendages • Chapter 11: pharyngeal apparatus • Chapter 26: Skeletal system • Chapter 27: Muscular system • Chapter 29: Clinical applications and ultrasonography in embryology • Chapter 30: Twins
  • 25. Some Images from book Figure 2.2: Process of spermatogenesis. Figure 2.4: Structure of sperm.
  • 26. Some Images from Yogesh’s Embryology Figure 3.2: Layers of uterine endometrium during proliferative phase of the menstrual cycle, and blood supply of endometrium Figure 4.3: Fertilisation. Phase of sperm penetration through coverings of the ovum
  • 27. Some Images from Yogesh’s Embryology Figure 4.7: Blastocyst. Differentiation of inner cell mass into epiblast and hypoblast. Figure 6.2: Day 9 embryo. Formation of trophoblastic lacunae.
  • 28. Some Images from Yogesh’s Embryology Figure 6.6: Day 13: Development of extraembryonic coelom and formation of secondary yolk sac. Figure 8.2: Embryo by day 24: side view
  • 29. Some Images from Yogesh’s Embryology Figure 8.11: Sagittal section of the embryo showing the derivatives of the endoderm. Figure 10.2: Development of hair. Shaft of hair follicle develops form surface ectoderm
  • 30. Some Images from Yogesh’s Embryology Figure 11.11: Anomalies of the position of the thyroid gland and locations of the thyroglossal cyst Figure 12.4: Development of the palate
  • 31. Figure 14.4: Transverse section through the region of the stomach showing the changes in the position of stomach, liver and spleen. Figure 14.12: Development of the anal canal.
  • 32. Figure 17.3: Separations of the pericardial, pleural and peritoneal cavities from each other.
  • 33. Scanning electron micrograph 18.3: Heart chambers and outflow tract. Figure 18.15: Tetralogy of Fallot.
  • 34. Figure 18.8: Development of interatrial septum.
  • 35. Figure 19.3: Relation of the pharyngeal arch arteries with foregut Figure 19.11: Cross section of the embryo showing major embryonic veins.
  • 36. Figure 20.3: A 28 days foetus showing pronephros, mesonephros and metaneprhos.
  • 37. Figure 21.6: Anomalies of processus vaginalis. A. Hydrocoele. B. Encysted hydrocoele. C. Hydrocoele with congenital inguinal hernia. Figure 22.4: Development of spinal cord.
  • 38. Figure 22.7: Developing spinal cord – positional changes
  • 39. Figure 22.16: A: In 8-week embryo, section showing medial surface of the right half of the telencephalon and diencephalon (red broken line indicates the plane of the section for B, C and D).
  • 40. Figure 22.18: Formation of commissures of telencephalon at 10 weeks (A) and 16 weeks (B). For integration of the activity of right and left cerebral hemispheres, commissures play a key role.
  • 41. Figure 22.1: Fully developed eyeball. Figure 23.3: Further development of eyeball (Day 29 and 33).
  • 42. Figure 24.3: Development of membranous labyrinth.
  • 43. Figure 25.3: Cross section of embryo showing developing adrenal gland Figure 27.3: Myotomes
  • 44. Figure 26.3: Endochondral ossification (development of long bone)
  • 45. About author: Dr Yogesh Sontakke MBBS, MD (Anatomy) • Currently working as Associate professor (Anatomy) at Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER) (An Institution of National Importance under the Ministry of Health & Family Welfare, Government of India), Pondicherry. • He also author other books: 1. Principles of Histological Techniques, Immunohistochemistry and Microscopy 2. Principles of Clinical Genetics 3. Principles of Scientific writing