Pathogenesis of Alzheimer's disease

1. PATHOGENESIS OF
ALZHEIMER’S DISEASE
Dr NIDHI RAI

2. AMYLOID CASCADE
HYPOTHESIS

6. TAU PROTEIN HYPOTHESIS

9. MORPHOLOGY OF
ALZHEIMER’S DISEASE

10. CORTICAL ATROPHY
71 yr male without AD 71 Yr male with AD

11. Coronal slice:
Disproportionately enlarged temporal horn of lateral ventricle
Narrowed entorhinal cortex

12. MICROSCOPIC FEATURES

13. NEUROFIBRILLARY TANGLES

14. GHOST TANGLES
Bielschowsky’s stain H & E

15. SENILE PLAQUE – MILIARY APPERANCE

16. NEURITIC PLAQUE
CLASSIC PLAQUE PERIVASCULAR PLAQUE

17. DIFFUSE PLAQUE
AMORPHOUS APPEARANCE WITHOUT SHOWING NEURITIC CHANGES
( BIELSCHOWSKY STAIN )

18. Striatum Cerebellar cortex

19. CEREBRAL AMYLOID ANGIOPATHY
THIOFLAVIN SILVER S STAIN SHOW AMYLOID DEPOSITION
WITHIN THE WALLS OF THE MENINGEAL BLOOD VESSELS.

20. HIRANO BODIES
 Refractile, brightly
eosinophilic, structures.
 Rod shaped, ovoid ,
spherical or cylindrical
structures.
 Characteristic Crystalloid
or “Herring-bone”
pattern.

21. GRANULOVACUOLAR DEGERNERATION

22. REFERENCES
Diagnostic neuropathology – Greenfield : 7th edition
Early diagnosis of Alzheimer’s : Scinto & Daffner
 Robbins
 Internet
Journals

23. THANK YOU