This presentation covers the detailed information about the recent advancements in pharamceutical industries. have a look to know more.

1. TECHNOLOGYADVANCEMENTS IN
PHARMACEUTICALS
BY
T.MOUNIKA GAYATHRI
M.S.PHARM (RT)
NIPER-HYD

2.  The pharmaceutical industry is an important component of health care
systems throughout the world.
 The quest for innovation is a major driving force in pharma.
 From the discovery of therapeutic biologicals in the 1920s, such as
Salvarsan and insulin, to the blockbuster drugs birthed in the 1990s, such as
Lipitor and Humira, pharma has always been on a quest for novel,
groundbreaking drug development.
 As we know that we are living in the age in which the technology is
moving rapidly. everything is getting advanced, we are creating new fields
and wrapping up the existing old models and process.
 As we are moving on technology advancement in various sectors, here are
some opportunities that are emerging in the healthcare and pharmaceutical
sector also.

3.  Modern scientific and technological advances are accelerating the
discovery and development of innovative pharmaceuticals with improved
therapeutic efficiency and reduced side effects.
 The technological advancements in pharmaceuticals is bringing hope to
the patients. We are improving healthcare through the use of innovative
digital technologies.
 So, in the following sections let’s have a glimpse at some of the great
technological advancements in the pharmaceutical industry.

4. DRUG 3D-PRINTING TECHNOLOGY
 In 3D printing, active ingredients and excipients are sprayed through a
nozzle to deposit three-dimensional structures in solid dosage forms.
 This layer-by-layer deposition of the drug ingredient gives rise to a three-
dimensional tablet.
 3D printing builds the pill by spreading layers of the drug on the top of one
another until it reaches to the right dose.
 This technology delivers an orodispersible tablet, which dissolves in
seconds with very little water.
 This technology is called as zipdose technology.
 Zipdose technology produces a product layer-by-layer without using
compression forces, punches or dies.

5. ADVANTAGES OF 3D PRINTING:
 Highly porous structure
 It has lattice work
 Rapidly sucks in liquid when it touches a sip of water
 It allows very large doses of drug in a single tablet (up to 1 gm)
 Collapses to form a suspension
 Its unique structure can’t be achieved using traditional
manufacturing methods
 High dose tablet with rapid dispersion
 Can be given to patients who struggle to swallow pills

6.  This is the world’s first 3D printed drug approved by the FDA.
 In 2015, Aprecia Pharmaceuticals developed Zipdose, patented
technology for 3D printing drugs to enable high-dose medications in a
rapidly disintegrating form.
 Using this technology, they then produced Spritam,
which treats Epilepsy.
 Spirtam is a reformulation of the anti-epileptic drug levetiracetam.

7. POLYPILLS
 Polypills offers many pills in one tablet, which reduces the number of tablet
intakes.
 As an example, captopril, nifedipine, and glipizide — three drugs used to
treat hypertension and type two diabetes — can be made available as a
single pill.
 Chewable medicines and fast-dissolving tablets aid in drug consumption
for young children and elderly people.
 FabRX is a biotech start-up that specializes in 3D printing medicines.
 Polypills can also be custom-made for specific patients based on their
health conditions.

9. NANOBOTS
 Nanobots are robots that can be used for effective drug delivery.
 These robots are known as Nanobots or Nanomedibots.
 Nanobots are made up of two different words i.e. nanotechnology and
robots.
 The circulatory system is a natural highway for these devices and the
nanomedibots will cruise through the blood stream to the area of distress.
 Light in the 700-1000 nanometer range will pass through tissue with
minimal absorption.
 They may be used to attach themselves to specific cells, such as cancer
cells, and report the position and structure of these tissues.

10.  Special sensor nanorobots can be inserted in to blood under the skin.
 Nanorobots are used to monitor the sugar levels in the blood.
 Using an MRI to precisely place the nanomedibots in the cancerous region,
the light causes the devices to heat to 131 degrees Fahrenheit which
destroys the cancerous cells but doesn’t damage surrounding tissues.
 Ribonucleic acid interference is a method that attacks cancers on a genetic
level. Nanobots laden with interfering RNA that deactivates the protein
production of the cancer and kills the malignancy.
 In addition to removing plaque from arterial walls, they could also be used
to find areas of arterial weakness.

11.  Nanorobots may also be employed to detect specific chemicals or toxins
and could give early warning of organ failure or tissue rejection.
 These machines will be able to repair damaged or diseased tissues at the
molecular level.