Prof. Ota~o

1. THE ENHANCEMENT OF
ALUMINUM SURFACE
AREA BY POLYMERS
TEMPLATE ASSISTANCE
Prof. Otaño
RISE Spring 2015
Sara Diaz
Patricia Rodriguez
Camille Ruiz
Justin Cotto

2. SIGNIFICANCE
Cancer therapy and bio imaging enhancement:
Theranostic probes
AuNP’s are biocompatible
Have vivid optical properties, and the flexibility to have
different molecules and materials attached to their shell
Scattering: AuNP’s become visible to imaging processes
Absorption: Phototermal ablation
Minimal damage to body cells
Gold nanoshells are shuttled into tumors by phagocytosis
A macrophage is formed
 Alternative:
 Placing drugs inside nanoparticle and using it as a vehicle
 Accomplished by coating outside of a nanoparticle with
iron oxide
Once the tumor area is coated with drug filled
nanoparticles, they are activated
(Loo 2005)

3. NANOSHELLS
UTILITY
THERAPY

4. TECHNIQUES
UTILIZED
 Electrospinning
 Cellulose Acetate
 Poly(vinyl alcohol) –Poly(acrylic
acid)
 Regenerated Cellulose
 Sputtering Deposition

5. ELECTROSPINNING
(Ning et. al. 2013)

6. SPUTTERING
UTILITIES
AND
ADVANTAGES
 Utility:
 Semiconductor industries
 Optical applications: glasses and telescopes
 Thin film transistors
 Low emissivity coatings on glass
 Fabrication of CD’s and DVD’s
 Efficient Photovoltaic solar cells
 Advantages:
 Materials with very high melting points are easily sputtered.
 Sputtered films typically have stronger adhesion on the substrate
 Target contains large amount of material and is maintenance free
 Sputtering sources contain no hot parts and are compatible with
reactive gases
 Size and relative thickness of the nanoshell can be controlled by
changing reaction time and plating concentration

7. PROBLEM
 Which polymer is easier to detach from the
deposited Aluminum, in order to acquire an
Aluminum nano-shell?
 Hypothesis
Cellulose acetate detaches easily.
Poly(vinyl alcohol) –Poly(acrylic acid) will
only detach when soaked in water.
Regenerated cellulose will not detach.

8. METHODOLOGY

9. SPUTTERING
DEPOSITION

10. METHODOLOGY

11. DETAILED
METHODOLOGY

12. METHODOLOGY

13. METHODOLOGY

14. METHODOLOG
Y
Deionized
water
Deionized
water +
Ethanol

15. RESULTS
✓Obtained:
✓Deposition of Al on fibers’ surface
✓Technical Issues

16. CONCLUSION
✓Hypothesis was unable to be proven
✓Future projects:
✓Evaluation of fibers through electron
microscope
✓Characterization of fiber morphology
✓Comparison of optimal templates

17. CITED
LITERATURE
Loo C, Lowery A, Halas N, West J, Dezek R. 2005.
Immunotargeted Nanoshells for Integrated Cancer Imaging and
Therapy. Nano Lett. [Internet; cited May 14]. Doi:
10.1021/nl050127s. Recovered at:
http://faculty.washington.edu/markeh/MSE599/Loo_Nanolett_2005.
pdf
Ning Z, Xiongbiao C. 2013. Biofabrication of Tissue Scaffolds in
book entitled. Advances in Biomaterials Science and Biomedical
Applications. Recovered at: http://ppl.ippt.gov.pl/18-few-words-
about/17-electrospinning

18. ACKNOWLEDGMENTS
 RISE PROGRAM
 Dr. Eneida Diaz
 Dr. Elena Gonzalez
 Mr. Giovanni Cruz
 Professor Ota-o and his students:
 Xavier Ortiz
 Normarieli Passalacqua
 Alejandra De Jesus

19. THE ENHANCEMENT OF
ALUMINUM SURFACE
AREA BY POLYMERS
TEMPLATE ASSISTANCE
Prof. Otaño
RISE Spring 2015
Sara Diaz
Patricia Rodriguez
Camille Ruiz
Justin Cotto