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Jason just had a physical exam. This was necessary for him to enter the second grade at his
school. He was voiding a urine sample for the school nurse, when a pink discoloration of
the urine was noted. The urine also appeared somewhat foamy (Jason thought this was
quite "neat"). Jason said his urine had been "real foamy" for a couple of days.
When questioned by the nurse about Jason's past history, his mother explained that Jason
had recently recovered from a strep throat infection that he got while the family was on
vacation several weeks ago.
The doctor examined Jason, noting his throat to be without erythema (redness) or other
lesions (abnormalities). No genital abrasions or other sites of potential bleeding into the
urine were noticed.
Jason appeared to be a bit puffy in the skin. Auscultation ( listening to organ sounds,
usually with a stethoscope) of the lungs revealed some sounds suggestive of fluid in the
lungs. Several bruises were noted scattered over Jason's skin, not noted on his last visit.
When asked about this, Jason's mother insisted that neither she nor her husband had hit
Jason, and that Jason had not hurt himself playing. The doctor made a note of this, as he
was required to report evidence of potential child abuse to the local authorities.
Routine lab tests of Jason's blood and urine were remarkable in the microscopic urine
examination showed red blood cells and red cellular (erythrocytes that are stuck together)
in the urine sediment, and Jason's serum protein concentrations was significantly
decreased.
Case Background
As blood course into the kidneys via the renal artery, it flows into smaller and smaller
vessels, coursing toward the cortex of the kidney. Once in the cortex of the kidney, the
blood vessels become small and torturous, forming capillary balls called glomeruli (about
one million per kidney). The glomerulus are permeable to certain substances that filter
across the glomerular capillary wall and enter the proximal convoluted tubule---forming
an ultrafiltrate that is destined for the ureters, bladder, and urethra where it will
ultimately be voided as urine.. Most substances that do not filter across the glomerular
capillary will continue on through the kidneys blood supply, leaving the kidney to reenter
the renal vein and ultimately the inferior vena cava (some substances that end up in the
urine do so by active peritubular secretions from blood vessels distal to the glomeruli that
surround the renal tubules.)
Normally only small molecular weight substances are filtered at the renal glomeruli
:sugars, fatty acids, ammonia acids, electrolytes, ( such as Na+, H+ K+) water and other
small molecules. Large molecules weight substances ( such as albumin, protein, clotting
proteins, certain hormones) and cells do not normally filter through the glomerular
filtrations barrier (capillary wall) to enter the renal urinary tubules.) substances not
normally filtered will tend to evaporate.
If the glomeruli are significantly damaged (by infection or inflammation) substances not
normally filtered will tend to entrap immune system complexes (composed of antigens
bound to antibodies) circulating in the vascular system. Following certain infections, most
notably beta hemolytic Streptococcus pyrogens ( the bacterium common ls responsible for
strep throat), antibodies to this bacterium combine with bacterial, antigen (bacterial
molecules) circulating in the blood; the antibody-antigen complexes frequently get
entrapped in the glomeruli. Such immune complexes bind special serum protein molecules
called complement. Complement then attracts white blood cells that release enzymes
destructive to any thing in the vicinity of the immune complex-----in this case the kidney
glomeruli. Such immune mediated destruction of the renal glomeruli will lead to
inflammation of the glomeruli, with subsequent leakage of even large molecules weight
serum proteins and often times red blood cells into the renal tubules.
What do red blood cells casts in the urine always indicate?
Why was Jason's serun protein level low?
Why was Jason's skin pffuy?
Why was Jason's skin bruised?
Why was the urine foamy?
Why did the lungs sound wet on auscultaion?
Is the recent infections significant?
How does it relate to the disease process occurring with Jason"s kidney?

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Jason just had a physical exam- This was necessary for him to enter th.pdf

  • 1. Jason just had a physical exam. This was necessary for him to enter the second grade at his school. He was voiding a urine sample for the school nurse, when a pink discoloration of the urine was noted. The urine also appeared somewhat foamy (Jason thought this was quite "neat"). Jason said his urine had been "real foamy" for a couple of days. When questioned by the nurse about Jason's past history, his mother explained that Jason had recently recovered from a strep throat infection that he got while the family was on vacation several weeks ago. The doctor examined Jason, noting his throat to be without erythema (redness) or other lesions (abnormalities). No genital abrasions or other sites of potential bleeding into the urine were noticed. Jason appeared to be a bit puffy in the skin. Auscultation ( listening to organ sounds, usually with a stethoscope) of the lungs revealed some sounds suggestive of fluid in the lungs. Several bruises were noted scattered over Jason's skin, not noted on his last visit. When asked about this, Jason's mother insisted that neither she nor her husband had hit Jason, and that Jason had not hurt himself playing. The doctor made a note of this, as he was required to report evidence of potential child abuse to the local authorities. Routine lab tests of Jason's blood and urine were remarkable in the microscopic urine examination showed red blood cells and red cellular (erythrocytes that are stuck together) in the urine sediment, and Jason's serum protein concentrations was significantly decreased. Case Background As blood course into the kidneys via the renal artery, it flows into smaller and smaller vessels, coursing toward the cortex of the kidney. Once in the cortex of the kidney, the blood vessels become small and torturous, forming capillary balls called glomeruli (about one million per kidney). The glomerulus are permeable to certain substances that filter across the glomerular capillary wall and enter the proximal convoluted tubule---forming an ultrafiltrate that is destined for the ureters, bladder, and urethra where it will ultimately be voided as urine.. Most substances that do not filter across the glomerular capillary will continue on through the kidneys blood supply, leaving the kidney to reenter the renal vein and ultimately the inferior vena cava (some substances that end up in the urine do so by active peritubular secretions from blood vessels distal to the glomeruli that surround the renal tubules.) Normally only small molecular weight substances are filtered at the renal glomeruli :sugars, fatty acids, ammonia acids, electrolytes, ( such as Na+, H+ K+) water and other small molecules. Large molecules weight substances ( such as albumin, protein, clotting proteins, certain hormones) and cells do not normally filter through the glomerular filtrations barrier (capillary wall) to enter the renal urinary tubules.) substances not normally filtered will tend to evaporate.
  • 2. If the glomeruli are significantly damaged (by infection or inflammation) substances not normally filtered will tend to entrap immune system complexes (composed of antigens bound to antibodies) circulating in the vascular system. Following certain infections, most notably beta hemolytic Streptococcus pyrogens ( the bacterium common ls responsible for strep throat), antibodies to this bacterium combine with bacterial, antigen (bacterial molecules) circulating in the blood; the antibody-antigen complexes frequently get entrapped in the glomeruli. Such immune complexes bind special serum protein molecules called complement. Complement then attracts white blood cells that release enzymes destructive to any thing in the vicinity of the immune complex-----in this case the kidney glomeruli. Such immune mediated destruction of the renal glomeruli will lead to inflammation of the glomeruli, with subsequent leakage of even large molecules weight serum proteins and often times red blood cells into the renal tubules. What do red blood cells casts in the urine always indicate? Why was Jason's serun protein level low? Why was Jason's skin pffuy? Why was Jason's skin bruised? Why was the urine foamy? Why did the lungs sound wet on auscultaion? Is the recent infections significant? How does it relate to the disease process occurring with Jason"s kidney?