Jason just had a physical exam. This was necessary for him to enter the second grade at his school. He was voiding a urine sample for the school nurse, when a pink discoloration of the urine was noted. The urine also appeared somewhat foamy (Jason thought this was quite "neat"). Jason said his urine had been "real foamy" for a couple of days. When questioned by the nurse about Jason's past history, his mother explained that Jason had recently recovered from a strep throat infection that he got while the family was on vacation several weeks ago. The doctor examined Jason, noting his throat to be without erythema (redness) or other lesions (abnormalities). No genital abrasions or other sites of potential bleeding into the urine were noticed. Jason appeared to be a bit puffy in the skin. Auscultation ( listening to organ sounds, usually with a stethoscope) of the lungs revealed some sounds suggestive of fluid in the lungs. Several bruises were noted scattered over Jason's skin, not noted on his last visit. When asked about this, Jason's mother insisted that neither she nor her husband had hit Jason, and that Jason had not hurt himself playing. The doctor made a note of this, as he was required to report evidence of potential child abuse to the local authorities. Routine lab tests of Jason's blood and urine were remarkable in the microscopic urine examination showed red blood cells and red cellular (erythrocytes that are stuck together) in the urine sediment, and Jason's serum protein concentrations was significantly decreased. Case Background As blood course into the kidneys via the renal artery, it flows into smaller and smaller vessels, coursing toward the cortex of the kidney. Once in the cortex of the kidney, the blood vessels become small and torturous, forming capillary balls called glomeruli (about one million per kidney). The glomerulus are permeable to certain substances that filter across the glomerular capillary wall and enter the proximal convoluted tubule---forming an ultrafiltrate that is destined for the ureters, bladder, and urethra where it will ultimately be voided as urine.. Most substances that do not filter across the glomerular capillary will continue on through the kidneys blood supply, leaving the kidney to reenter the renal vein and ultimately the inferior vena cava (some substances that end up in the urine do so by active peritubular secretions from blood vessels distal to the glomeruli that surround the renal tubules.) Normally only small molecular weight substances are filtered at the renal glomeruli :sugars, fatty acids, ammonia acids, electrolytes, ( such as Na+, H+ K+) water and other small molecules. Large molecules weight substances ( such as albumin, protein, clotting proteins, certain hormones) and cells do not normally filter through the glomerular filtrations barrier (capillary wall) to enter the renal urinary tubules.) substances not normally filtered will tend to evaporate. If the glomeruli are significantl.