Dengue fever

1. 1
Amjad Khan Afridi Date: 12th
May, 2017
DENGUE FEVER
THE DENGUE FEVER
 Dengue virus (DENV) belong to the Flavivirus genus of the Flaviviridae family.
 Transmitted by Aedes Aegypti.
 The disease:
 Dengue fever.
 Dengue hemorrhagic fever ( DHF).
 Dengue shock syndrome.
 Threats:
 50 million infections per year.
 500000 develop DHF.
 22000 deaths per year.
 Current treatment :
 No vaccine.
 Limited efficiency of antiviral drugs.
 Treatment for DHF is blood transfusion.
Dengue serotypes
 There are 5-dengue virus serotypes Den1- Den5.
 All dengue i.e flaviviruses have common group epitopes on the envelope proteins.
 Results in extensive cross- section of Ag and Ab complex.
TRANSMISSION:
 Global warming
 Virus unable to transmitted at <26c
 Peak season is 15 April---15 Oct
 Source is infected person
 Incubation period: 4---7 days

2. 2
Amjad Khan Afridi Date: 12th
May, 2017

3. 3
Amjad Khan Afridi Date: 12th
May, 2017
 NS1: it is imp for viability of den V. And is present in high conc, in blood of patient.
 NS3: it is a serine protease and RNA helicase and its co factor is NS2B.
 NS5: it codes for RNA dept RNA polymerase.
 NS4B: it is hydrophobic protein located in a association with ER. It blocks phosphorylation of
STAT1 (Signal transducer and activator of transcription) after induction by IF a, beta.
 NS2A, NS4A are cofactors.
Replication

4. 4
Amjad Khan Afridi Date: 12th
May, 2017
Symptoms of Dengue fever
Diagnosis and treatment:
 Dx: CBC,LFTs
 Dengue serology,PCR(Ns1)
 Treatment: panadol only, no antibiotics NSAIDs etc
 Fresh juices of fruits and papaya leaves are better to give.
Prepared by
Amjad Khan Afridi Date: 12th
May, 2017