Syphilis is caused by the bacteria Treponema pallidum. Penicillin is the drug of choice for treating all stages of syphilis. For early syphilis, a single injection of 2.4 million units of benzathine penicillin G is adequate. For late syphilis, this dose may be repeated weekly for 3 weeks. Alternative drugs like tetracycline can be used in patients allergic to penicillin, except in cases of neurosyphilis, pregnancy, or HIV infection which require desensitization to penicillin first. Patients treated for syphilis require follow up testing to monitor the effectiveness of treatment.

1. Treatment
for Syphilis
S.Yogeeswara Reddy
Roll no-108
MBBS- IInd yr
PESIMSR

3. Syphilis is caused by an bacteria
(Treponema pallidum). Any disease
caused by bacteria is commonly
treated with antibiotics.
Once upon a time, Penicillin is most
commonly used antibiotic for
treatment of many bacteria causing
diseases.

4. Syphilis is easy to cure in its early stages.
1. Penicillin is the drug of choice for all the
stages of syphilis.
(a). Early syphilis:-
A single Injection of 2.4million units of
benzathine Penicillin G is adequate.
(b). Late syphilis:-
The above dose may be repeated
weekly for 3 weeks.

5. 2. Alternative drugs is used in patients with
Penicillin allergy:-
For 1°, 2°, latent , syphilis, CVS or benign 3°
syphilis -- tetracycline is recommended.
For neurosyphilis or in pregnancy or
associated HIV-- desensitization to
penicillin has to be done, following which
penicillin is administered.

6. Note:-
Jarisch - Herxheimer is a condition
that results due to a reaction to
lipoproteins released by the death of
Treponema pallidum, during the
antibiotic treatment to syphilis.

7. Monitoring after treatment:-
Patients treated for 1°& 2° syphilis should have
follow-up VDRL testing at 6, & 12 months after
treatment.
Patients with HIV infection should be
monitored at 3, 6, 9, & 12 months, as they
are known to have more rapid progression
of disease.