The 10 Most Advanced Medical Imaging Solution Providers 2023.pdf

MAY | ISSUE : 02 | 2023
Pg.No: 24
Enriching the Global Healthcare
with Precise Imaging Solutions
Pg.No: 32
DR. MAX AHNEN
COO and Co-founder
POSITRIGO
JANNIS FISCHER
CEO and Co-founder
POSITRIGO
Global Exploration
Naviga ng the Complex
World of Medical Imaging
Demystifying Advancements
Understanding the
Technology and Applica ons
of Advanced Imaging

Positrigo’s vision is to
‘imaging everyone,’ which
means that it wants to
broaden the availability of
func onal imaging and to
allow a wide range of
pa ents with brain-related
disorders the access to
precision imaging.

Editor’s
Note
n the fast-paced world of healthcare, advanced
Imedical imaging has become an indispensable tool
for accurate diagnosis and treatment planning. As
technology continues to evolve, so does the need
for innovative and reliable medical imaging
solution providers. These companies play a crucial role in
equipping healthcare facilities with state-of-the-art imaging
equipment, software, and support services that enable
healthcare professionals to deliver optimal patient care.
The realm of advanced medical imaging encompasses a
wide range of modalities, including magnetic resonance
imaging, computed tomography, positron emission
tomography, and ultrasound. Each modality has its unique
advantages and applications, catering to the diverse needs
of different medical specialties. As such, medical imaging
solution providers must offer a comprehensive portfolio of
imaging systems, ensuring they can meet the specific
requirements of healthcare providers across various
disciplines.
In today’s interconnected world, interoperability and data
integration are paramount. Leading medical imaging
solutions providers offer solutions that seamlessly integrate
with hospital information systems and electronic medical
records, allowing for efficient data management and
streamlined workflows.
Global Facilitation
with Contemporary
Emulations

This interoperability enhances communication and
collaboration between healthcare providers, facilitating
better patient care and improved outcomes.
As we navigate the complex landscape of advanced medical
imaging, it is essential to recognize and acknowledge the
contributions of these solution providers. Their dedication
to innovation, customer support, and data integration is
instrumental in advancing the ﬁeld of medical imaging and
revolutionizing healthcare. By partnering with the right
medical imaging solution provider, healthcare facilities can
stay at the forefront of technology, providing the highest
standard of care to their patients.
Through the latest edition – The 10 Most Advanced
Medical Imaging Solution Providers 2023 of The CIO
World, we delve into the world of advanced medical
imaging solution providers, exploring their role,
innovations, and impact on healthcare delivery. We
highlight the importance of choosing the right partner in
advancing medical imaging capabilities and achieving
excellence in patient care.
-Prh D. Bombarde
CIO

Enriching the Global
Healthcare
with Precise
Imaging Solutions
08
JANNIS FISCHER
CEO and Co-founder
POSITRIGO
DR. MAX AHNEN
COO and Co-founder
POSITRIGO
C O V E R
S T O R Y

Stringing a Powerful Cord of Futuris c
Data-Centric Computer Vision
Encord Medical Imaging
Consultancy
20
Flourishing Healthcare
with Exquisite Solu ons
Mirada
Medical
An Anecdote of Health,
Hope, and Healing!
36
28
Global Exploration
Naviga ng the Complex
World of Medical Imaging
Understanding the
Technology and Applica ons
of Advanced Imaging
32
24

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RNI No.: MAHENG/2018/75953
ISSUE 02 | MAY | 2023
Renuka Kulkarni

S
David Westgate
Chairman, President & CEO
Carestream Health Healthcare
Carestream Healthcare
carestream.com
Carestream Healthcare serves
industrial markets globally
with non-destruc ve tes ng
products, enabling customers
to capture high-quality images
for applica ons such as aircra
inspec on, assemblies,
cas ngs and forensics.
Ted Mosler
CEO
Gilero
gilero.com
Gilero has become highly
sought-a er by industry
leaders and one of the
most trusted medical
device design companies.
From concept
development to contract
manufacturing and design.
Roger Gunn
PhD, Chief Scien fic Officer
Invicro LLC
invicro.com
Invicro is an integral part
of the REALM IDx, Inc.
group, which aims to
accelerate personalized
medicine, discover novel
therapeu c targets and
develop innova ve
therapeu c technologies
for unmet medical needs.
Deepak Behera
Managing Director
Medical Imaging
Consultancy
medicalimagingconsultancy.com
Medical Imaging
Consultancy approach is
strategy driven and
customized to each need,
understanding the
constraints of me,
resources and logis cs
unique to each
technology and company.
Eric Landau
Co-founder and CEO
Encord
encord.com
Encord offers a
comprehensive pla orm to
streamline data flows,
create high quality training
data through AI assisted
annota on, and find & fix
errors in your model to get
to produc on AI faster.
Featuring
Company
Brief
Featuring
Company
Brief
Featuring
Company
Brief
Kenji Sukeno
Representa ve Director &
Board Chairman
Fujifilm Holdings
holdings.fujifilm.com
FujiFilm Holdings is comprised
of more than 20 affiliate
companies spanning across a
broad spectrum of industries
including medical and life
sciences, electronic, chemical,
graphic arts, informa on
systems, mo on picture,
broadcast and photography.
Jon DeVries
CEO
Mirada Medical
mirada-medical.com
Mirada Medical's purpose
is to accelerate cancer
care. They believe that by
making cancer care
universally available, free
of delays and equipped to
use the latest techniques
they can improve pa ent
outcomes and experience.
Jannis Fischer (CEO) &
Dr. Max Ahnen (COO)
Co-founders
Positrigo
positrigo.com
Positrigo vision is to make
func onal imaging
accessible for people
worldwide and create a
las ng social impact.
Yasunori Yamamoto
President and CEO
Shimadzu Corpora on
shimadzu.com
The analy cal and
measuring instruments,
industrial machinery, and
aircra equipment that
Shimadzu Corpora on
provides are used in a
wide range of industries.
Dr. Bernd Montag
CEO
Siemens Healthcare
siemens-healthineers.com
Siemens Healthcare is at
the center of clinical
decision-making and
treatment pathways.
Pa ent-centered
innova on has been and
always will be at the core
of our company.

JANNIS FISCHER
CEO and Co-founder
POSITRIGO

C O V E R S T O R Y
Enriching the Global Healthcare
with Precise Imaging Solutions
As a medical device
manufacturer, we try to
support them by oﬀering a
state-of-the-art imaging
device at a fac on of
today´s cost.
The 10 Most Advanced Medical Imaging Solu on Providers 2023

Positrigo imaging solu ons
have paved a new dimension
in the crucial diagnosis of
rapidly evolving diseases of
Demen a, Alzheimer’s disease,
Lewy Body Demen a (LBD),
Vascular Demen a, and
Frontotemporal Demen a,
respec vely.
hile examining any critical health condition,
Wdoctors identify and ascertain the reason for the
patient’s health situation by checking primary
symptoms through the visible changes in skin, nails, hair,
and tongue to understand the eating and sleeping habits of
the patient.
Moving further to pinpoint the exact illness, doctors insist
to conduct pathological tests and several diagnostic
procedures, including medical imaging techniques. In
recent healthcare advancements, medical imaging plays a
significant role throughout the entire clinical process—from
diagnostics and treatment planning to—surgical procedures
and follow-up studies.
Modern advancements in medical science have brought
forward specific and accurate imaging methods that give a
clear idea through images of the internal body organs of the
patients and provide accurate diagnostic results.
Medical imaging gives an exact image of the affected organ
or the body parts to be studied, enabling the doctors in
having a clearer idea of the ailment and take decisions on
the subsequent treatments.
Providing innovative imaging solutions, Positrigo has
emerged as a reliable MedTech organization that has made
value-added functional imaging accessible to people
worldwide and has been creating a lasting social impact.
Headquartered in Zurich, Switzerland, Positrigo is guided
by its CEO Dr. Jannis Fischer and its COO Dr. Max
Ahnen (both co-founders), in its journey of excellence.
Positrigo has been advancing the clinical routine by
facilitating broad research in diagnostics, treatment
monitoring and the development of new therapies. With a
vision to make functional imaging accessible for people
worldwide and to create a lasting social impact. Positrigo
makes functional imaging scalable – “imaging everyone!”
Visionary Inspirations
In 2017, Prof. em. Dr. Alfred Buck – the former head of the
NeuroPET program at University Hospital Zurich - came to
Positrigo with a vision to develop a dedicated brain
Positron Emission Tomography (PET) system. One field of
use is Alzheimer’s disease, whose hallmarks can be seen in
PET. As more than 100 drugs are on the horizon – 2 of them
already FDA-cleared – as an urgent matter. Based on its
know-how from particle physics on how to design and build
complex detector systems, the Positrigo team went onto the
journey of making PET imaging more available and
more affordable. Within this year the company will
be ready to help Dr. Buck and thousands of his peers
to do the imaging their patients in need for a proper
diagnosis.
Guiding Leadership
Jannis studied physics at FU and HU Berlin with exchanges
to ETH Zurich, the University of California Los Angeles,
and CERN. During his PhD at ETH Zurich, he worked on
the development of SAFIR, a small animal PET system
with unprecedented temporal resolution. BPET (a SAFIR
spin-off) started in 2017 with the grant of an ETH Pioneer
Fellowship to Max and Jannis. Since then, other awards
have followed, e. g. VentureKick and Forbes Europe 30
under 30.
The saga of this phenomenal organization began when
Jannis Fischer and Max Ahnen were PhD students in
particle physics and the above idea was conceived. With
their background in detector design and construction as well
as software development, they managed to build a fully
functional prototype within two years. It was used to scan
ten patients in a pilot clinical trial. This system was the
basis for the company Positrigo, which has since built a
team of engineers working on making it a medical device.

JANNIS FISCHER
CEO and Co-founder
POSITRIGO
DR. MAX AHNEN
COO and Co-founder
POSITRIGO

Positrigo has been
advancing the clinical
rou ne by facilita ng
broad research in
diagnos cs, treatment
monitoring and the
development of new
therapies

By the end of 2023, the management expects to have
regulatory approval in Europe to start marketing the
device.
Driving Fundamentals
Positrigo’s vision is to “imaging everyone,” which
means that it wants to broaden the availability of
functional imaging and to allow a wide range of
patients with brain-related disorders the access to
precision imaging. The company is built around the
following core values:
1. Customer Focus - We put customers first
2. Quality - We demand excellence
3. Collaboration - We work well together
4. Passion and Commitment - We care
Key Differentiators
The product offering of Positrigo is unique as
NeuroLF, is one of the smallest dedicated brain PET
systems coming to market in 2023. Beside the ultra-
compact design, the device offers high patient comfort
and satisfaction, it comes with an attractive price-value
proposition and is intuitive and easy to use.
NeuroLF offers a variety of USPs, namely…
Ÿ Limited space requirements
Ÿ Intuitive and easy to use
Ÿ High patient comfort and satisfaction
Ÿ Compelling price-value proposition
Positrigo’s imaging solutions have paved a new dimension
in the crucial diagnosis of rapidly evolving diseases of
Dementia, including Alzheimer’s disease, Lewy Body
Dementia (LBD), Vascular Dementia, and Frontotemporal
Dementia, respectively.
Abnormal brain changes cause the disorders grouped under
the general term “dementia”. These changes trigger a
decline in thinking skills, also known as cognitive abilities,
severe enough to impair daily life and independent
function. When there is no test to determine if some patient
has dementia, the physicians diagnose types of dementia
based on a careful medical history, a physical examination,
laboratory tests and functional imaging. Among the various
tests, Positron Emission Tomography (PET) is known as the
gold standard in functional imaging for dementia diagnosis.
Alzheimer’s disease has been a serious concern that affects
around 40 million individuals worldwide, causing a
tremendous medical and socio-economic burden.
Specialized dementia diagnosis is critical to be able to offer
individualized therapy and to monitor treatment progress.
This is precisely why Positrigo has developed a solution
which assists in making specialized Alzheimer’s disease
diagnostic more broadly available.
LBD or the Lewy body dementia (LBD), is a disease
associated with abnormal deposits of a protein called alpha-
synuclein in the brain. These deposits, called Lewy bodies,
affect chemicals in the brain whose changes, in turn, can
lead to problems with thinking, movement, behavior, and
mood. The Positrigo imaging solutions help the doctors in
tracing alpha-synuclein and help to identify the possibilities
of LBD.
Vascular dementia is basically referring to describing
problems with reasoning, planning, judgment, memory, and
other thought processes caused by brain damage from
impaired blood flow to the brain. Factors that increase the
risk of heart disease and stroke — including diabetes, high
blood pressure, high cholesterol and smoking — also raise
the vascular dementia risk. Controlling these factors may
help lower the chances of developing vascular dementia.
Positrigo imaging helps in detecting after such and elements
that can identify the possibilities of severe diseases, thereby
offering the doctors with the right direction in diagnosis and
offering the proper consultation to the patients with
convincing evidence, making them aware of the gravity of
the situation and encourage their cooperation in the
treatments.
NeuroLF is an efficient and reliable imaging system that
can help in diagnosing Frontotemporal Dementia.
Frontotemporal dementia (FTD), a common cause of
dementia, is a group of disorders that occur when nerve
cells in the frontal and temporal lobes of the brain are lost.
This causes the lobes to shrink. These shrinkages are
neurodegeneration, which is visible through the NeuroLF
imaging of neurodegeneration tracers.
In Neuro Oncology, over the past decades, brain PET with
numerous radiolabelled molecules has been evaluated to
overcome limitations of conventional MRI in the Neuro-
Oncology assessment. The task force of the Response
Assessment in Neuro-Oncology (RANO) working group
emphasized that for gliomas, the additional clinical value of
radiolabelled amino acids compared with standard MRI is
outstanding and justifies the widespread clinical use.

I am happy and proud
to say that we have
been very fortunate at
Positrigo to a ract the
right talent to develop
cu ng-edge imaging
technologies.

It is known that amino acid PET can help to define
metabolic hotspots for specific tumour tissue sampling, a
technique that can be particularly useful if biopsy rather
than open resection is considered.
For neuro-oncologists and medical professionals involved
in the diagnosis and care of patients with brain tumors, the
following three indications for PET imaging are of
particular clinical interest:
Ÿ The identification of neoplastic tissue, including the
delineation of tumor extent for the further diagnostic
and therapeutic management
Ÿ The differentiation of treatment related changes from
tumor progression at follow-up
Ÿ The assessment of response to a certain anticancer
therapy, including its (predictive) effect on the patients’
outcome
Epilepsy is one condition that might occur because of a
genetic disorder or an acquired brain injury, such as a
trauma or stroke. During a seizure, a person experiences
abnormal behaviour, symptoms, and sensations, sometimes
including loss of consciousness.
For patients with epilepsy a PET scan is used to localize the
part of the brain that is causing the seizure activity. There
are various PET tracers to measure glucose, serotonin and
oxygen metabolism, cerebral blood flow and receptor
binding in epilepsy. Imaging brain glucose metabolism with
18Fluoro-2-deoxyglucose (FDG) PET is the most utilized
technique in routine clinical practice.
Making an Impact
The vision and goals are designed to make functional
imaging accessible to everyone. Positrigo has planned to
accomplish this by developing a dedicated brain PET
system that is capable to offer functional imaging with the
same quality and performance standards as the much larger
whole-body devices but at a fraction of today’s cost. This
would allow even smaller neurologist offices to offer brain
PET imaging thus enabling much more patients to benefit
from this highly precise diagnostic modality.
From the Beginning to the End
Besides the initial product training Positrigo team is always
ready to help and be of support along the way. It offers
trainings on demand for the new employees and / or
prepares continuing education opportunities for the
previously trained clinicians. Positrigo provides the latest
updates on its developments through its clinical newsletters
on the following topics of
Ÿ Clinical Training on Demand
Ÿ Educational Webinars
Ÿ Whitepapers and Case Stories
Ÿ Continuing Education Opportunities
Expert Opinion
Speaking from the industry perspective, Jannis says, “The
healthcare sector is a very challenging sector where the
delivery of high-quality patient care contrasts with
permanent cost pressure. Therefore, it is – in my view -
critical for healthcare providers to constantly look for
improvements, process optimizations and to remain
innovative. As a medical device manufacturer, we try to
support them by offering a state-of-the-art imaging device
at a faction of today’s cost.”
Reflecting Experience
Replying as an advice to the young medical professionals,
Jannis said, “My advice to entrepreneurs and enthusiasts
aspiring to venture into the medical imaging niche is to stay
very close to clinicians who are using the imaging
technology on a daily basis. This will allow you to design a
solution-centred device and a technology that the end users
will accept.
In addition, it is prudent to bring a team of subject matter
experts together as the development of imaging technology
is highly complex and requires unique expertise and skill
sets. I am happy and proud to say that we have been very
fortunate at Positrigo to attract the right talent to develop
cutting-edge imaging technologies.”
Expanding in Newer Geographies
Positrigo’s plan to scale newer horizons is by bringing its
first product to market in Europe in 2023. Together with its
dedicated sales partners, it plans to deliver the first devices
and to recognize revenue by the end of this year. In 2024
the company expects to obtain FDA clearance for its
technology which will allow it to penetrate the US
geographies. For this reason, Positrigo aims to grow its
sales team in the US, focusing on becoming the market
leader for dedicated brain PET systems with the vision to
“imaging everyone”.

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CIO

nnovations do not have to be always solving huge
Iproblems. Rather powerful innovations are those
which solve everyday issues for those who are the
most important social contributors like healthcare givers.
This is the story of such an innovative company which is
stringing a powerful cord between technology and
healthcare professionals by using futuristic data-centric
computer vision.
Doctors in the Division of Nephrology, at Stanford
Medicine, were facing a complex problem. They had to use
three different kinds of software to identify, annotate, and
count podocytes and glomeruli in microscopy images.
Similarly, King's College London had been using clinicians
to annotate pre-cancerous polyp videos had prohibitively
high costs to produce large datasets. Likewise, Memorial
Sloan Kettering Cancer Center staff were finding detecting
and classifying vena cava filters in complex label structures
(ontologies) rendered existing and open-source tools
unusable.
Simply, in the words of King's College's Director for
Gastroenterology and Endoscopy, this has been like mental
torture to them. As the director and many more heads of
such institutions were living in the agony thinking they had
to endure it lifelong, came along Encord and using the
power of advanced technologies like AI and ML, first its
Co-founder and CEO, Eric Landau convinced Stanford to
use Encord's annotation tools and SDK to automate
segmentations, count, and calculate sizes of segments. The
result was astonishing, as with Encord, Stanford researchers
reduced experiment duration from an average of 21 to 4
days (80%) while processing 3X the number of images.
Eric also convinced Dr Bu Hayee, the Director from King's
College to deploy Encord's micro-model module to increase
clinician labelling efficiency and automate 97% of produced
labels. Again the result was outstanding with the highest
expense clinician seeing 16X labelling efficiency
improvement, cutting down the model development time
from one year to two months and a 6.4X average increase in
labelling efficiency for GI videos.
Furthermore, MSK adopted Encord to build custom label
structures for pulmonary thrombosis projects, thus making
them entirely feasible for the company. Today, Machine
learning and data operations teams of all sizes use
Encord's collaborative applications, automation features,
and APIs to build models and annotate, manage, and
evaluate their datasets.
In Eric's words, "We work with some of the world's leading
AI companies, enterprises, hospitals, and research
institutions."
Elaborating on his own journey Erics shares that during his
undergrad, he studied physics. He began a PhD but left to
take a job in finance. After almost a decade of working in
finance, Eric was ready for a new challenge. He joined an
entrepreneur network here in London, which is where he
met Ulrik. Ulrik told Eric about his seed idea for Encord,
stressing the need to solve the data bottleneck by
automating data annotation in medical AI and beyond.
Erics reveals, "I thought it was the best startup idea I had
heard, and it was a lot better than the ones I had had, so we
founded the company and began solving the problems
associated with putting together and managing high-quality
training data for machine learning models."
In an interview with The CIO World, Eric spoke at length
about the inception, the journey and their future plans for
Encord.
Stringing a Powerful Cord of Futuris c
Data-Centric Computer Vision
10 Most Advanced Medical Imaging Solu on Providers 2023
www.thecioworld.com MAY, 2023
20

Encord was named by CB Insights as one of the 100 most promising private AI
companies of 2022. In this interview, King’s College Hospital’s Director for
Gastroenterology and Endoscopy Dr Bu Hayee discusses how Encord’s tool
eliminated the “mental torture” of manual data labelling.
In this NVIDIA post, Fareedc Iqbal, the CEO of SurgEase, a company that oﬀers
telepresence technology for gastroenterology, said, “Encord’s so ware has been
instrumental in aiding us in solving some of the hardest problems in endoscopic
disease assessment.”
Encord’s technology has been used by Stanford University, King’s College London,
and Memorial Sloan Ke ering. Case studies with links to academic papers are
available on Encord’s website h ps://encord.com/
Encord's
Hallof
Fame
Eric Landau
Co-founder and CEO
Encord
21

However, until recently, the AI world has been very model-
centric, so healthcare professionals haven't been able to use
AI to its full potential. By taking a data-centric approach to
AI and focusing on improving the quality and quantity of
the training data used to train medical AI models, we can
eliminate potential demographic biases and make model
predictions as realistic as possible to what happens in a
clinical setting. Because we want medical professionals to
be able to use AI in practice in a way that's consistent with
the values of the medical profession, Encord has focused on
delivering an efficient, user-friendly platform that allows
for all the security, privacy, and integrity expected when
handling patient data.
Kindly elaborate upon the services that make Encord
stand out as one of the most advanced medical imaging
solution providers in the modern healthcare industry.
We are technologically focused. We knew this problem
needed a more sustainable, long-term solution than the
current solutions which were built upon improving manual
labelling processes or increasing the amount of manual
labellers. Rather than continue to throw a lot of doctors at
the problem, we wanted to create a technological solution
that used doctors' time as efficiently as possible. The micro-
model technology we developed enables doctors to
automate data labelling with just a handful of manually
labelled images. We are the only company that provides an
automated solution to the problem of annotating training
data.
We are also very hands-on from a company-to-consumer
perspective. We don't throw one-size-fits-all solutions at a
problem; instead, we really try to understand each
individual customer's needs to make sure they get the
solution most likely to work for their existing issues.
What is your opinion on healthcare providers' aligning
their offerings with newer technological developments,
especially when it comes to catering to the dynamic
needs of the healthcare space?
We are technologically forward-thinking, so we encourage
healthcare providers to align their offerings with newer
technological developments. That said, those technological
solutions also have to work and deliver real-world value, so
the technology shouldn't just be used because of the hype
surrounding it. When it comes to machine learning, this is
where the power of data-centric AI really comes into play.
Encord's mission is to
accelerate the pace of
data-centric AI in
medicine so that
healthcare institutions
and medical
professionals can reap
the benefits of this
technology.
Herein are the highlights of that exclusive interview!
Eric, please brief our audience about Encord and kindly
tell us the source of inspiration for venturing into the
medical imaging niche.
We are an early-stage startup that provides a computer-
vision-first platform for annotating and managing training
data. When my co-founder Ulrik was studying at Imperial
College London, he worked on a project where he was
visualizing scale image datasets for medical AI. Through
this work, he realized the difficulties that doctors face when
labelling these images. Hand labelling medical images take
an enormous amount of time, so Encord started off working
in the medical imaging field because he understood how
suboptimal the data annotation process was, and how it
could be done a lot more efficiently if doctors had a
technological solution for it.
Can you elaborate upon the core values on which
Encord is built, what is its vision and mission?
At Encord, we value curiosity and a growth mentality. Our
team prioritizes humility– being willing to learn from
mistakes– and resourcefulness–being scrappy and creative
when solving new problems– which enables them to
develop great products and deliver high-quality customer
support.
Encord's mission is to accelerate the pace of data-centric
AI in medicine so that healthcare institutions and medical
professionals can reap the benefits of this technology. AI
has the potential to make healthcare and medical treatments
increasingly proactive rather than reactive.
22

A healthcare provider could use a very sophisticated model,
but if the model hasn't been trained on a vast amount of data
that is reflective of the patient population, then the
technology and its outputs will be fundamentally flawed.
Healthcare providers need to put processes in place that
validate the technology and make sure it delivers valuable,
real-world patient care. Conditional upon that, they
shouldn't be shy about or afraid of using technology
because it can be immensely useful in delivering patient
care.
What advice would you like to give to the budding
entrepreneurs and enthusiasts aspiring to venture into
the medical imaging niche that you are catering to?
Don't assume you know the answer to the problem or even
the problem itself. You need to talk to a lot of people to
understand the problem and its solution. Don't be shy about
talking to people.
Talk to doctors, nurses, AI professionals, and as many other
stakeholders as you can. Really listen to them to understand
their experience and the challenges they're encountering. A lot
of entrepreneurs will speak first and say, "This is what I think
the problem is," but that's not the right approach.
First, you listen, then you synthesize the information you've
learned in all of these conversations to understand the
problem, and finally, you begin to formulate a solution from
that starting point.
How do you envision scaling Encord's services and
operations in 2023 and beyond?
We're going to continue the growth of the team and expand
geographically, with a particular focus on the U.S. market
where we are working to establish a stronger presence. We
also have exciting new healthcare-focused partnerships in the
works, with some of the world's best academic institutions and
industrial AI partners.
23

Navigating
of
Complex
the WORLD
MEDICAL
IMAGING
edical imaging is a rapidly evolving field that
Mplays a vital role in modern healthcare. It
encompasses various imaging modalities and
technologies that enable healthcare professionals to
visualize and diagnose a wide range of medical conditions.
Further, we embark on a global exploration of the complex
world of medical imaging, delving into its advancements,
challenges, and impact on patient care!
The Evolution of Medical Imaging
The journey of medical imaging began with the discovery
of X-rays by Wilhelm Conrad Roentgen in 1895. Since
then, the field has experienced remarkable advancements,
with the development of technologies such as ultrasound,
computed tomography (CT), magnetic resonance imaging
(MRI), and nuclear medicine. Each imaging modality offers
unique capabilities and is used for specific diagnostic
purposes, contributing to the comprehensive toolkit
available to healthcare professionals.
Advancements in Imaging Technology
In recent years, medical imaging technology has undergone
significant advancements, revolutionizing the field. Digital
imaging has replaced traditional film-based techniques,
providing enhanced image quality, faster image acquisition,
and improved storage and accessibility of patient data.
Furthermore, the integration of artificial intelligence (AI)
algorithms has revolutionized medical imaging by
automating processes, assisting in image interpretation, and
aiding in the detection of abnormalities.
Applications in Diagnostic Medicine
Medical imaging plays a critical role in the diagnosis and
management of various medical conditions. X-rays are
commonly used to evaluate fractures, detect lung diseases,
and assess dental health. Ultrasound is invaluable in
prenatal care, assessing cardiac function, and detecting
abnormalities in organs such as the liver, kidneys, and
reproductive system. CT scans provide detailed cross-
sectional images, aiding in the diagnosis of cancer,
cardiovascular diseases, and neurological conditions. MRI
offers exceptional soft tissue contrast, making it particularly
valuable in diagnosing brain, spinal, and musculoskeletal
disorders. Nuclear medicine techniques, including positron
emission tomography (PET), enable the visualization of
metabolic activity, aiding in the detection and staging of
cancer, cardiac diseases, and neurological conditions.
Challenges and Limitations
While medical imaging has transformed healthcare, it is not
without challenges and limitations. One significant concern
is the increasing demand for imaging services, leading to
longer wait times and potential delays in diagnosis.
24

Global Exploration
25

To Conclude,
The complex world of medical imaging holds immense
significance in modern healthcare. From its humble
beginnings to the current era of cutting-edge technology,
medical imaging has revolutionized diagnostics, treatment
planning, and patient care. Advancements in imaging
technology, the wide range of applications, and ongoing
research and innovation have propelled the field forward.
However, challenges such as access, wait times, radiation
exposure, and resource disparities persist. It is crucial to
address these challenges through collaborative efforts,
technological advancements, and policy changes.
Promoting equitable access to imaging services, enhancing
training programs, and fostering international collaborations
are key steps in navigating the complex world of medical
imaging on a global scale.
Moving forward, the future of medical imaging holds
tremendous promise. Advancements in AI, machine
learning, and data analytics will further enhance image
analysis, improve diagnostic accuracy, and expedite patient
care. Emerging technologies, such as molecular imaging
and functional imaging, will unlock new possibilities in
personalized medicine and targeted therapies. Ethical
considerations and patient-centered care must remain at the
forefront, ensuring the responsible and beneficial use of
medical imaging technologies.
As healthcare continues to evolve, the global exploration of
medical imaging will remain essential in transforming
patient outcomes and shaping the future of healthcare
delivery. With continued dedication, collaboration, and
innovation, we can navigate the complexities of medical
imaging and unlock its full potential in improving
healthcare worldwide.
-P.D.Bombarde
Limited access to imaging facilities, particularly in remote
or underserved areas, poses another obstacle. Additionally,
ensuring patient safety, minimizing radiation exposure, and
managing the increasing volume of imaging data are
ongoing challenges that require careful attention and
innovative solutions.
Global Perspectives on Medical Imaging
Medical imaging practices vary across countries and
healthcare systems globally. Developed nations often have
well-established infrastructure, advanced imaging
technologies, and comprehensive quality control measures.
In contrast, developing regions face resource constraints,
limited access to advanced imaging modalities, and a
shortage of trained personnel. Efforts are underway to
bridge these gaps through initiatives like telemedicine,
mobile imaging units, and training programs for healthcare
professionals. Collaborative partnerships between
organizations, governments, and global health agencies are
crucial for sharing expertise, knowledge, and resources to
improve access to medical imaging services worldwide.
Research and Innovation
Medical imaging serves as a foundation for research and
innovation in healthcare. The analysis of large datasets of
medical images allows researchers to identify patterns,
develop predictive models, and gain new insights into
disease mechanisms. Collaboration between imaging
specialists, clinicians, and researchers is crucial for
advancing the field and translating research findings into
clinical practice. Furthermore, ongoing research aims to
develop novel imaging techniques, enhance imaging
protocols, and explore innovative applications in areas such
as precision medicine and image-guided therapies.
Ethical Considerations and Patient-Centered Care
As medical imaging continues to advance, ethical
considerations and patient-centered care become
increasingly important. Protecting patient privacy, ensuring
informed consent, and maintaining data security are critical
aspects of the provision and utilization of medical imaging.
Additionally, maintaining a patient-centered approach
involves effective communication with patients, addressing
their concerns, and providing clear explanations about the
imaging procedures and their implications.
26

Bringing new products and technologies to market in
the healthcare field can be a challenging feat to
manage, given the complexities of today’s global
market trends, cultural considerations, and need for value
driven solutions.
A business’s need and vision, the impact on stakeholders,
and marketplace forces, may need careful balancing. A
symbiotic relationship among various stakeholders sought
and nurtured in a business venture allows not just co-
existence, but also the synergistic possibility of untapped
growth potential.
In recent years, we have seen a paradigm shift in healthcare
and new-gen technologies. This includes the rapidly
advancing area of radiopharmaceuticals and medical
imaging technologies. There is a high need and demand for
partners with relevant expertise to support the incoming
growth in this extremely specialized and niche area.
Deepak Behera, MD at Medical Imaging Consultancy,
has set out to support this need by bringing together
distinctive proficiencies towards development and
commercialization of products and technologies in medical
imaging.
We discussed with Deepak Behera on his journey towards
founding Medical Imaging Consultancy, his core principles,
and his views on the changing landscape of healthcare
space in general.
Here are some of the highlights of the discussion:
Please brief our readers about Medical Imaging
Consultancy and kindly tell us the source of your
inspiration for venturing into the medical imaging
niche.
I think clinical development, regulatory approval, and
market adoption of medical imaging products, especially
using radiopharmaceuticals, is a complex and niche
environment. There are numerous and significant
differences to be considered between this type of medicine
and other pharma and device industries, including
regulatory pathways, clinical study designs, business needs
assessment, logistics, and scale of manufacturing and
supply chain, as well as eventual clinical market
positioning.
This can be daunting to understand and navigate, and new
entrants into this field often struggle to manage these
complexities.
At the same time, medical imaging and
radiopharmaceuticals are a rapidly growing field, and new
products addressing a multitude of clinical needs are
constantly entering the market. There is a mismatch
between innovators and people with relevant experience
and understanding of the multiple aspects in this field
necessary to take such products to market.
This was the inspiration for establishing Medical Imaging
Consultancy, or MiC in short.
Flourishing Healthcare with Exquisite Solu ons
10 Most Advanced Medical Imaging Solu on Providers 2023
Medical
Consultancy
28

Dr. Behera is a physician-scien st turned
execu ve with more than 20 years of
experience across the pharmaceu cal
industry, health technologies, academia,
and clinical health care fields.
He began as a Nuclear Medicine physician
and transi oned into “bench-to-bedside”
academic and scien fic research at Stanford
University. A er that, he gained experience
in the industry of medical affairs and clinical
development.
He pairs his training as a physician with his
ability to think as an academic, allowing
clients to receive expert knowledge in
clinical development & FDA interac ons.
There are many facets to understanding
payer and clinical adop ons, the logis cs
unique to radiopharmaceu cals, medical
affairs strategy, product launch, and
commercializa on.
These are all necessary components when
naviga ng the complex
radiopharmaceu cal first-in-human to
market pathway, and Dr. Behera excels at
maneuvering through these nuances.
Dr. Behera enjoys the challenge of balancing
the structured medical and regulatory
environments with the innova ve realm of
crea ng commercial value by iden fying,
defining, and ar cula ng the best product-
market fits and establishing new clinical
pathways via educa onal marke ng.
TheVersatile
Leader
Deepak Behera
MD
Medical Imaging Consultancy

My team and I set out to solve this need by using our
existing and growing knowledge of this industry and
partnering with early to mid-stage pharma, biotech, and
device companies to provide strategic and operational
advice related to radiopharmaceutical and medical imaging
products.
In addition to having an in-house knowledge base, MiC also
leverages a network of adjacent service providers in
marketing, payer engagement, regulatory operations,
clinical operations, chemistry, physics, statistics, medical
writing, dosimetry, CROs, clinical trial sites, etc. to fill gaps
and needs for our partners.
Over the years, MiC has built fundamental relationships
with major manufacturers and suppliers of
radiopharmaceuticals and imaging products, most major
universities and academic centers in the US, as well as a
vast number of community radiologists and nuclear
medicine physicians. We are able to strategically utilize this
network to prepare for launching products onto the market.
We offer our clients a variety of services such as clinical
development strategy and planning, a customized strategy
plan, product-market analysis, commercialization, and
product launch activities.
Medical Imaging Consultancy is built and its mission?
The goal of Medical Imaging Consultancy is to nudge
healthcare towards a better patient outcome while
generating value along the way for all stakeholders.
My team and I aim to be the support information system
companies need to launch them towards future growth and
success. We are vested in our client’s success, and our
mission is to guide them to a place where they have the
tools and knowledge to operate self-sufficiently.
MiC’s goal is to become an extension of our client’s team,
get in their shoes, and endeavor toward our mutual success.
Given the nature of industry needs, this is much better
appreciated by our partners and clients as opposed to a
transactional model, where service providers are recruited
and paid for specific deliverables without a solid attachment
to the client’s problems and overall vision and strategy.
Our belief is that if we do good, good will come to us.
Kindly elaborate upon the services that make Medical
Imaging Consultancy stand out from the competition.
What makes us stand out is our ability to bring synergy
from various fields and interest in the success of our clients
as opposed to simply completing a project or getting further
business.
Our organization comprises experts in research
development, medical affairs, clinical trial design and
support, and regulatory strategy. We are committed to
helping businesses design thoughtful and successful
development & marketing plans to minimize time and cost.
At the same time, maximize efforts for product positioning
for marketing, development, and investment potential.
MiC offers a wide range of services, including:
• Clinical development strategy and planning.
• Regulatory support in clinical questions and decisions,
including FDA interactions.
• Clinical trial design, including image analysis
strategies.
• Clinical/Medical executive representative for sponsor.
(e.g., fractional CMO roles)
• Medical/clinical support for clinical operations –
drafting and reviewing of clinical trial protocols and
other study documents, reviewing the interpretation of
clinical trial data, site visits for training and education.
• US representative for non-US companies.
• Medical advice, strategy, and management for
investigator-sponsored studies.
• Medical monitoring and consulting for
pharmacovigilance, including being client’s medical
safety officer.
• Clinical/scientific support for business development
activities and strategic collaborations.
• Product launch and post-marketing medical affairs,
including development reader training programs,
training, and educational materials for field personnel.
If we do good,
good will come
to us.
,,
,,
30

• Technology evaluation for investment and business
decisions.
• Clinical support for intellectual property creation.
What is your opinion on healthcare providers’ aligning
especially when it comes to catering to the dynamic
needs of the healthcare space?
Healthcare is in a major evolutionary re-vamp right now.
We have seen a dynamic shift in the practice and
management of healthcare over the last few years due to
COVID-19. This has created the need for a more fluid
healthcare space, which requires integrated and patient-
focused technology to be developed.
Healthcare is currently undergoing the transformation that
transportation went from a ‘taxi only’ to a co-existing ‘taxi
& Uber’ or vacationing went from a ‘hotel only’ to a co-
existing ‘hotel & AirBnB’ stage.
Healthcare is rapidly adopting a hybrid old-school clinic
plus telemedicine scenario.
In addition, the traditionally closed and siloed healthcare
environment is opening up to myriads of possibilities by
beginning to allow data from various silos to interact with
each other. The potential for data science, machine learning,
and even artificial intelligence to impact healthcare is
enormous at both individual and population levels.
We are re-training ourselves on what the healthcare model
should look like, and this is a great place to be for the
growth and development of new ideas and tools which will
improve the practice of medicine.
Need drives change, which is often the most challenging
roadblock regarding new product design and integration.
The need is here, and we are committed to helping to bring
the change.
the medical imaging niche you are catering to?
There is a significant need in the medical imaging and
radiopharmaceutical development area. We wholeheartedly
welcome more interest in this area. This is a multi-specialty,
multi-dimensional area in need of very many skill-sets.
My advice to entrepreneurs venturing into this will be two-
fold: one, identify and understand what they want to
achieve; two, realize that it takes a village to accomplish
anything related to medical imaging. Engaging the people
with the right skill-set to achieve their goals will be the key
to success.
We always encourage new ideas because those will
ultimately be the future. Big things always start small, and
we aim to help turn those ideas into reality.
How do you envision scaling Medical Imaging
Consultancy in 2023 and beyond?
Our offering is our personnel and subject matter expertise.
We plan to expand by bringing on more expert consultants
as well as our footprint on social media and continue our
participation in networking events, thus allowing us to
expand our community of partners and product placement
experts.
We are committed to continuous learning so that we can
bring new ideas to the table for our clients. Individuals
interested in learning more and becoming a part of Medical
Imaging Consultancy are always welcome for a chat over a
cup of coffee.
31

Understanding the
Technology and
Applications of
Advanced Imaging
A
dvanced imaging technologies have
revolutionized the field of healthcare, enabling
healthcare professionals to visualize and
diagnose medical conditions with
unprecedented detail and accuracy.
Further, we delve into the intricacies of advanced imaging,
exploring the technology behind it and the wide range of
applications that benefit patients and healthcare providers!
The Technology Behind Advanced Imaging
Advanced imaging encompasses a variety of technologies,
each offering unique capabilities for capturing and
interpreting medical images. These technologies include
magnetic resonance imaging (MRI), computed tomography
(CT), positron emission tomography (PET), and single-
photon emission computed tomography (SPECT). Each
imaging modality utilizes different principles and equipment
to generate detailed images of the human body.
MRI relies on powerful magnets and radio waves to create
detailed images of soft tissues, organs, and internal
structures. CT scans utilize a combination of X-rays and
computer algorithms to produce cross-sectional images of
the body. PET and SPECT employ radioactive tracers that
32

emit gamma rays to detect metabolic and molecular activity
within the body.
Applications in Diagnostics
Advanced imaging technologies have significantly
improved the accuracy and speed of diagnoses across
various medical specialties. In radiology, advanced imaging
plays a crucial role in the detection and characterization of
tumors, identification of abnormalities in the cardiovascular
system, evaluation of musculoskeletal injuries, and
assessment of brain disorders. In cardiology, advanced
imaging techniques aid in the diagnosis of heart diseases,
evaluation of blood flow, and assessment of cardiac
function. Additionally, advanced imaging is invaluable in
oncology for staging tumors, monitoring treatment
response, and guiding surgical interventions.
Advancements in Image-Guided Interventions
Advanced imaging has also transformed the field of image-
guided interventions, where medical procedures are
performed with real-time imaging guidance. Techniques
such as interventional radiology, image-guided surgery, and
minimally invasive procedures rely on advanced imaging
technologies to precisely target and treat specific areas of
the body. These advancements have led to shorter procedure
times, reduced invasiveness, improved patient outcomes,
and faster recovery.
Innovations in Artificial Intelligence
Artificial intelligence (AI) has emerged as a powerful tool
in advanced imaging, revolutionizing image analysis and
interpretation. AI algorithms can analyze large datasets of
medical images, identify patterns, and assist healthcare
professionals in diagnosing diseases. For example, AI
algorithms can aid radiologists in detecting subtle
abnormalities in mammograms for early breast cancer
detection or assist in the detection of lung nodules on CT
scans. AI-powered software can also help radiologists
prioritize urgent cases, streamline workflow, and improve
diagnostic accuracy.
Challenges and Considerations
While advanced imaging technologies offer numerous
benefits, they also present challenges and considerations.
Accessibility and affordability of advanced imaging can
vary, especially in resource-limited settings.
33

Maintenance and operational costs of imaging equipment
can be significant, requiring healthcare institutions to
carefully manage their resources. Additionally, patient
safety, radiation exposure, and the ethical use of patient
data are critical concerns that must be addressed.
Future Directions and Possibilities
The future of advanced imaging holds tremendous promise.
Ongoing research aims to enhance the speed and resolution
of imaging techniques, develop novel contrast agents, and
refine image reconstruction algorithms. Furthermore,
advancements in hybrid imaging, combining multiple
imaging modalities, may lead to even more precise and
comprehensive diagnostic capabilities. Integration with
other technologies, such as robotics and virtual reality, may
further enhance surgical interventions and training.
To Conclude,
Advanced imaging technologies have become invaluable
tools in modern healthcare, empowering healthcare
professionals to provide accurate diagnoses, guide
interventions, and improve patient outcomes.
Understanding the technology behind advanced imaging
and its vast applications is essential for healthcare providers
and patients alike. As advancements continue, it is crucial
to address challenges, promote accessibility, and ensure the
responsible use of advanced imaging technologies. With
ongoing research, we can expect even more remarkable
developments in the field of advanced imaging. The
integration of artificial intelligence and machine learning
will further enhance image analysis and interpretation,
leading to more precise and efficient diagnoses. Moreover,
advancements in imaging technology will likely result in
improved image quality, faster acquisition times, and
reduced radiation exposure for patients.
To fully harness the potential of advanced imaging,
collaboration between researchers, healthcare professionals,
and technology developers is vital. By working together,
they can address challenges, share knowledge, and drive
innovation in the field. Additionally, ongoing efforts to
improve access to advanced imaging technologies,
particularly in underserved areas, will help ensure that
patients around the world can benefit from these life-saving
advancements.
As we navigate the complex world of advanced imaging, it
is crucial to prioritize patient safety, data security, and
ethical considerations. Striking a balance between
technological advancements and patient-centered care will
be key to delivering the best possible outcomes for
individuals.
-P.D.Bombarde
34

An Anecdote of Health, Hope, and Healing!
cience and society have always been working in
Standem. Be it the ever-evolving technological
transformation, rediscovering algorithms, or
transgressing software advantages for diagnostics segments
of healthcare, the scientific inventions have been
transforming society for the better.
Understanding this bridging role of technology that
integrates science with society, it is important to scout,
learn and acknowledge the hustles of healthcare disruptors
who are paving the way for the next generational
innovations in the diagnostics segment, specifically in the
radiology niche.
And, if one scouts around the modern trends of diagnostics
marvel, it is hardly possible to be inconsiderate towards
medical imaging solution providers. Instigated with such
mindboggling thought, we at The CIO World investigated
around the globe and dropped by one of the leading
imaging and radiotherapy companies. Known for its agile
development and trustworthy approach is Mirada Medical.
As a leading platform for the powerful image registration,
visualization, and contour editing software, Mirada
exemplifies the true meaning of technology leadership
while twirling the wind and ensuring that every cancer
patient finds hope in the healthcare community.
Standing at the helm of this transformation is its Chief
Executive Officer, Jon DeVries, an influential leader for
the Miradaites. He is an expert in world-leading medical
software systems, and since he joined Mirada, he has been
dedicated to delivering transformative innovation in the
cancer care segment.
To know more about the Mirada and its executive leader-
Jon DeVries, explore the further excerpts from the interview!
Jon, please enlighten us about Mirada Medical and
kindly tell us about your source of inspiration for
venturing into the medical imaging niche.
Mirada is a world leader in software for quantitative image
analysis and disease characterization used to diagnose
cancer and guide the delivery of radiation-based treatments.
Mirada's software is currently used in over 2,000 hospitals
globally and sold directly to hospitals as well as through
strategic partnerships with the world's leading imaging and
radiotherapy companies, including GE, Boston Scientific,
Canon, Philips, Varian, and Change Healthcare.
We are at a key stage in
Mirada's evolution with some
new solutions and partnerships
in development that will once
again see Mirada break ground
in a new category.
36

Seasoned business leader Jon
DeVries joined Mirada Medical as
CEO in September 2021. DeVries
is a renowned tech visionary
known for advancing ar ficial
intelligence (AI) adop on in
healthcare and commercializing
medical imaging solu ons.
Since joining Mirada Medical, Jon
has sort to comprehended the
world-leading scien fic, so ware,
and medical capabili es of the
organiza on and focused them on
clear areas of cancer care where
it can deliver the most value.
Having already established the AI-
Autocontouring category in
cancer care, Jon's work paves the
way for Mirada to deliver
transforma onal innova on in
exci ng new areas of cancer care.
An Adept
Leadership
Jon DeVries
CEO
Mirada Medical
Mirada Medical is built, what is its mission and vision
for the modern healthcare industry?
Our purpose is to accelerate cancer care. We believe that by
making cancer care universally available, free of delays,
and equipped to use the latest techniques, we can improve
patient outcomes and experience. Medical imaging sits at
the heart of this, and through our scientific advancement,
technical innovation, and clinical expertise we deliver
solutions that personalize image-guided cancer treatment
and help clinicians achieve this goal.
Kindly elaborate upon the services that positioned
Mirada Medical as one of the advanced medical imaging
solution providers in the healthcare industry.
Mirada's leadership and innovation are founded on its
scientific credentials and proactive willingness to work with
industry partners. Solutions, such as RTx, Mirada's
powerful image registration, visualization, and contour
editing software, are so well respected that when GE
Healthcare sort of enhancing their own cancer visualization
and diagnostic capabilities, they integrate it fully into their
solutions. Equally, this 'Mirada Inside' approach sees its
37

technologies integrated into solutions offered by industry
heavyweights such as Canon, Reflexion, SORNA, and
Boston Scientific.
What is your opinion on healthcare providers' aligning
especially when it comes to catering to the ever-evolving
needs of the healthcare sector?
Healthcare providers have always had to innovate their
offerings and stay in touch with developments, in order to
improve patient outcomes. The challenge today is the
phenomenal pace of change that clinics have to contend
with and the sophisticating demands of the patient.
Healthcare providers need to be agile and equipped to move
quickly to evaluate and adopt the latest technologies. At the
same time, vendors like Mirada need to bring to market
solutions that can be seamlessly integrated into workflows
with zero to minimal impact on the operations of the clinic.
the medical imaging niche?
Have a focus and purpose that puts the patient at the heart
of everything that you do. You may never engage directly
with a patient, but through your service or your partner's,
patient outcomes should drive everything that you do.
How do you envision scaling Mirada Medical's services
and operations in 2023 and beyond?
We are at a key stage in Mirada's evolution with some new
solutions and partnerships in development that will once
again see Mirada break ground in a new category. We're
tremendously excited, but I'm afraid that launch
announcements will come later in the year. So, watch this
space.
Please give us a few testimonials from your clients and
awards or recognition that accurately highlight your
organization's position in the market.
''Mirada RTx has become an indispensable part of the
treatment preparation workflow in our clinic. The software
provides us with a ton of options for image registration and
contouring in a user-friendly environment that enables you
to generate your own layouts and macros. Mirada
employees are very communicative and helpful, offering
support via online meetings when necessary. During live
visits, they dive into our clinical workflows to be able to
adapt the software to our specific needs.''
Ÿ Ellen Brunenberg, Medical Physicist, Department of
Radiation Oncology, Radboudumc, Nijmegen, The
Netherland
''The Mirada application has exceeded my expectations. XD
is so much better than anything I've read on before.''
Ÿ Phillip Kuo, MD, PhD, Professor, Medical Imaging,
University Medical Center Tucson, AZ
38

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