SlideShare a Scribd company logo

Friability testing

Information on Friability test explained in the presentation.

1 of 13
Download to read offline
Srinivasa Reddy. Edururi
Aurobindo Pharma Limited.
 Friability (the condition of being Friable)
testing is used to test the durability of
tablets during packing processes and
transit. This involves repeatedly dropping a
sample of tablets over a fixed time, using a
rotating drum with a baffle.
 In simple words, friability test tells how
much mechanical stress tablets are able to
withstand during their manufacturing,
distribution and handling by the customer.
 The friability tests should be performed for
compressed, uncoated tablets.
 For delayed release tablets, friability is
usually controlled on the tablet core prior to
the coating operation.
 Measurement of tablet friability
supplements other physical strength
measurements, such as tablet breaking
force.
 Throughout pharmaceutical industry,
friability testing has become an accepted
technology and the instrument used in to
perform this process is called Friabilator or
Friability Tester.
 Friability apparatus is having a drum with
following characteristics.
◦ Material of construction (MOC): Synthetic Polymer
with polished internal surfaces, and subject to
minimum static build-up
◦ Internal diameter: Between 283 mm and 291 mm
◦ Depth: Between 36 mm and 40 mm
◦ Inside radius: between 75.5 mm to 85.5 mm
◦ Rotating speed: 25±1 rpm.
Friability testing
Ad

Recommended

TABLET COMPRESSION MACHINE
TABLET COMPRESSION MACHINETABLET COMPRESSION MACHINE
TABLET COMPRESSION MACHINESagar Savale
 
Evaluation of tablet
Evaluation  of  tabletEvaluation  of  tablet
Evaluation of tablettasirsalman
 
Inprocess as per usp ip bp tablets
Inprocess as per usp ip bp tabletsInprocess as per usp ip bp tablets
Inprocess as per usp ip bp tabletsDeepak Jain
 
Quality control tests for tablets
Quality control tests for tabletsQuality control tests for tablets
Quality control tests for tabletsDr. Raja Abhilash
 
Disintegration and dissolution tests
Disintegration and dissolution testsDisintegration and dissolution tests
Disintegration and dissolution testsAmera Abdelelah
 

More Related Content

What's hot

Evaluation of capules
Evaluation of capulesEvaluation of capules
Evaluation of capulesShaik Sana
 
IPQC for capsule.
IPQC for capsule.IPQC for capsule.
IPQC for capsule.ganpat420
 
Evaluation of dosage forms
Evaluation of dosage formsEvaluation of dosage forms
Evaluation of dosage formsShaik Sana
 
TABLET COMPRESSION
TABLET COMPRESSIONTABLET COMPRESSION
TABLET COMPRESSIONSAJJAD AHMAD
 
quality control test for soft gelatin capsule and minim per gram factor
quality control test for soft gelatin capsule and minim per gram factorquality control test for soft gelatin capsule and minim per gram factor
quality control test for soft gelatin capsule and minim per gram factorSUJIT DAS
 
QUALITY CONTROL OF CAPSULES
QUALITY CONTROL OF CAPSULESQUALITY CONTROL OF CAPSULES
QUALITY CONTROL OF CAPSULESRamya priya
 
Tablet equipments
Tablet equipmentsTablet equipments
Tablet equipmentsMd Mohsin
 
Quality control tests of tablet
Quality control tests of tabletQuality control tests of tablet
Quality control tests of tabletSarangDalvi
 
IPQC Tests for capsules As per IP, BP & USP
IPQC Tests for capsules As per IP, BP & USPIPQC Tests for capsules As per IP, BP & USP
IPQC Tests for capsules As per IP, BP & USPPramod Ramane
 
Qc tets for tablets final
Qc tets for tablets finalQc tets for tablets final
Qc tets for tablets finalChowdaryPavani
 
Dissolution Testing Apparatus
Dissolution Testing ApparatusDissolution Testing Apparatus
Dissolution Testing ApparatusSourav Kar
 
DISSOLUTION TESTING APPARATUS
DISSOLUTION TESTING APPARATUSDISSOLUTION TESTING APPARATUS
DISSOLUTION TESTING APPARATUSBushra S
 
Disintegration Tester.pptx
Disintegration Tester.pptxDisintegration Tester.pptx
Disintegration Tester.pptxANANT NAG
 
In process & finished products quality control test for pharmaceuticals
In process & finished products quality control test for pharmaceuticalsIn process & finished products quality control test for pharmaceuticals
In process & finished products quality control test for pharmaceuticalsSuraj Ghorpade
 
Tablet friability,harness and dissolution testing
Tablet friability,harness and dissolution testingTablet friability,harness and dissolution testing
Tablet friability,harness and dissolution testingdonjacob81
 

What's hot (20)

Evaluation of capules
Evaluation of capulesEvaluation of capules
Evaluation of capules
 
Disintegration
DisintegrationDisintegration
Disintegration
 
IPQC for capsule.
IPQC for capsule.IPQC for capsule.
IPQC for capsule.
 
Evaluation of dosage forms
Evaluation of dosage formsEvaluation of dosage forms
Evaluation of dosage forms
 
TABLET COMPRESSION
TABLET COMPRESSIONTABLET COMPRESSION
TABLET COMPRESSION
 
quality control test for soft gelatin capsule and minim per gram factor
quality control test for soft gelatin capsule and minim per gram factorquality control test for soft gelatin capsule and minim per gram factor
quality control test for soft gelatin capsule and minim per gram factor
 
QUALITY CONTROL OF CAPSULES
QUALITY CONTROL OF CAPSULESQUALITY CONTROL OF CAPSULES
QUALITY CONTROL OF CAPSULES
 
Tablet equipments
Tablet equipmentsTablet equipments
Tablet equipments
 
Quality control tests of tablet
Quality control tests of tabletQuality control tests of tablet
Quality control tests of tablet
 
IPQC Tests for capsules As per IP, BP & USP
IPQC Tests for capsules As per IP, BP & USPIPQC Tests for capsules As per IP, BP & USP
IPQC Tests for capsules As per IP, BP & USP
 
Qc tets for tablets final
Qc tets for tablets finalQc tets for tablets final
Qc tets for tablets final
 
Dissolution Testing Apparatus
Dissolution Testing ApparatusDissolution Testing Apparatus
Dissolution Testing Apparatus
 
DISSOLUTION TESTING APPARATUS
DISSOLUTION TESTING APPARATUSDISSOLUTION TESTING APPARATUS
DISSOLUTION TESTING APPARATUS
 
Disintegration Tester.pptx
Disintegration Tester.pptxDisintegration Tester.pptx
Disintegration Tester.pptx
 
Granulation ppt.
Granulation ppt.Granulation ppt.
Granulation ppt.
 
Single punch tablet press PPT
Single punch tablet press PPTSingle punch tablet press PPT
Single punch tablet press PPT
 
In process & finished products quality control test for pharmaceuticals
In process & finished products quality control test for pharmaceuticalsIn process & finished products quality control test for pharmaceuticals
In process & finished products quality control test for pharmaceuticals
 
Tablet Evaluation
Tablet EvaluationTablet Evaluation
Tablet Evaluation
 
Preformulation
PreformulationPreformulation
Preformulation
 
Tablet friability,harness and dissolution testing
Tablet friability,harness and dissolution testingTablet friability,harness and dissolution testing
Tablet friability,harness and dissolution testing
 

Similar to Friability testing

Quality control test of tablets
Quality control test of tabletsQuality control test of tablets
Quality control test of tabletsTanmayPanigrahy
 
QUALITY CONTROL OF TABLETS
QUALITY CONTROL OF TABLETSQUALITY CONTROL OF TABLETS
QUALITY CONTROL OF TABLETSTeny Thomas
 
Industrial Pharmacy, Quality control of tablets.pdf
Industrial Pharmacy, Quality control of tablets.pdfIndustrial Pharmacy, Quality control of tablets.pdf
Industrial Pharmacy, Quality control of tablets.pdfAlishaKhatun4
 
Ipqc tests for tablet
Ipqc tests for tabletIpqc tests for tablet
Ipqc tests for tabletMalay Jivani
 
dissolution test apparatus
dissolution test apparatusdissolution test apparatus
dissolution test apparatusDeepali69
 
Quality Control Test
Quality Control TestQuality Control Test
Quality Control TestTalhaAfzal13
 
Presentation on quality control and quality assurance of medicines by tite ...
Presentation  on quality control and quality assurance of medicines  by tite ...Presentation  on quality control and quality assurance of medicines  by tite ...
Presentation on quality control and quality assurance of medicines by tite ...UWAMBAJINEZATite
 
In Process Quality Control System (IPQC) for Solid Dosages Form (Tablets)
In Process Quality Control System (IPQC) for Solid Dosages Form (Tablets)In Process Quality Control System (IPQC) for Solid Dosages Form (Tablets)
In Process Quality Control System (IPQC) for Solid Dosages Form (Tablets)Gaurav kumar
 
IPQC and FPQC tests for Tablets
IPQC and FPQC tests for TabletsIPQC and FPQC tests for Tablets
IPQC and FPQC tests for TabletsSonali Pradhan
 
Friability test presentation
Friability test presentationFriability test presentation
Friability test presentationAsgharullahKhan
 
Non sterile manufacturing process technology
Non sterile manufacturing process technologyNon sterile manufacturing process technology
Non sterile manufacturing process technologyPRANJAY PATIL
 
Non sterile manufacturing process technology
Non sterile manufacturing process technologyNon sterile manufacturing process technology
Non sterile manufacturing process technologyPRANJAY PATIL
 
Ipqc for tablets correctd
Ipqc for tablets correctdIpqc for tablets correctd
Ipqc for tablets correctdceutics1315
 
Quality Control Tests For Tablets and Capsules(QC)
Quality Control Tests For Tablets and Capsules(QC)Quality Control Tests For Tablets and Capsules(QC)
Quality Control Tests For Tablets and Capsules(QC)mdpavel
 

Similar to Friability testing (20)

Quality control test of tablets
Quality control test of tabletsQuality control test of tablets
Quality control test of tablets
 
QUALITY CONTROL OF TABLETS
QUALITY CONTROL OF TABLETSQUALITY CONTROL OF TABLETS
QUALITY CONTROL OF TABLETS
 
Industrial Pharmacy, Quality control of tablets.pdf
Industrial Pharmacy, Quality control of tablets.pdfIndustrial Pharmacy, Quality control of tablets.pdf
Industrial Pharmacy, Quality control of tablets.pdf
 
IPQC TEST
IPQC TEST IPQC TEST
IPQC TEST
 
IPQC TESTS
IPQC TESTSIPQC TESTS
IPQC TESTS
 
Ipqc tests for tablet
Ipqc tests for tabletIpqc tests for tablet
Ipqc tests for tablet
 
dissolution test apparatus
dissolution test apparatusdissolution test apparatus
dissolution test apparatus
 
Quality Control Test
Quality Control TestQuality Control Test
Quality Control Test
 
Tablets- A Detailed Review
Tablets- A Detailed Review Tablets- A Detailed Review
Tablets- A Detailed Review
 
Quality control complete notes
Quality control complete notesQuality control complete notes
Quality control complete notes
 
Table quality control test
Table quality control test Table quality control test
Table quality control test
 
Presentation on quality control and quality assurance of medicines by tite ...
Presentation  on quality control and quality assurance of medicines  by tite ...Presentation  on quality control and quality assurance of medicines  by tite ...
Presentation on quality control and quality assurance of medicines by tite ...
 
In Process Quality Control System (IPQC) for Solid Dosages Form (Tablets)
In Process Quality Control System (IPQC) for Solid Dosages Form (Tablets)In Process Quality Control System (IPQC) for Solid Dosages Form (Tablets)
In Process Quality Control System (IPQC) for Solid Dosages Form (Tablets)
 
IPQC and FPQC tests for Tablets
IPQC and FPQC tests for TabletsIPQC and FPQC tests for Tablets
IPQC and FPQC tests for Tablets
 
Tablets
TabletsTablets
Tablets
 
Friability test presentation
Friability test presentationFriability test presentation
Friability test presentation
 
Non sterile manufacturing process technology
Non sterile manufacturing process technologyNon sterile manufacturing process technology
Non sterile manufacturing process technology
 
Non sterile manufacturing process technology
Non sterile manufacturing process technologyNon sterile manufacturing process technology
Non sterile manufacturing process technology
 
Ipqc for tablets correctd
Ipqc for tablets correctdIpqc for tablets correctd
Ipqc for tablets correctd
 
Quality Control Tests For Tablets and Capsules(QC)
Quality Control Tests For Tablets and Capsules(QC)Quality Control Tests For Tablets and Capsules(QC)
Quality Control Tests For Tablets and Capsules(QC)
 

Recently uploaded

2.20.24 The March on Washington for Jobs and Freedom.pptx
2.20.24 The March on Washington for Jobs and Freedom.pptx2.20.24 The March on Washington for Jobs and Freedom.pptx
2.20.24 The March on Washington for Jobs and Freedom.pptxMaryPotorti1
 
Chromatography-Gas chromatography-Principle
Chromatography-Gas chromatography-PrincipleChromatography-Gas chromatography-Principle
Chromatography-Gas chromatography-Principleblessipriyanka
 
Shapley Tech Talk - SHAP and Shapley Discussion
Shapley Tech Talk - SHAP and Shapley DiscussionShapley Tech Talk - SHAP and Shapley Discussion
Shapley Tech Talk - SHAP and Shapley DiscussionTushar Tank
 
Overview of Databases and Data Modelling-2.pdf
Overview of Databases and Data Modelling-2.pdfOverview of Databases and Data Modelling-2.pdf
Overview of Databases and Data Modelling-2.pdfChristalin Nelson
 
BTKi in Treatment Of Chronic Lymphocytic Leukemia
BTKi in Treatment Of Chronic Lymphocytic LeukemiaBTKi in Treatment Of Chronic Lymphocytic Leukemia
BTKi in Treatment Of Chronic Lymphocytic LeukemiaFaheema Hasan
 
2.20.24 Asian Americans and the Myth of the Model Minority.pptx
2.20.24 Asian Americans and the Myth of the Model Minority.pptx2.20.24 Asian Americans and the Myth of the Model Minority.pptx
2.20.24 Asian Americans and the Myth of the Model Minority.pptxMaryPotorti1
 
UniSC Moreton Bay Library self-guided tour
UniSC Moreton Bay Library self-guided tourUniSC Moreton Bay Library self-guided tour
UniSC Moreton Bay Library self-guided tourUSC_Library
 
Diploma 2nd yr PHARMACOLOGY chapter 5 part 1.pdf
Diploma 2nd yr PHARMACOLOGY chapter 5 part 1.pdfDiploma 2nd yr PHARMACOLOGY chapter 5 part 1.pdf
Diploma 2nd yr PHARMACOLOGY chapter 5 part 1.pdfSUMIT TIWARI
 
ICSE English Literature Class X Handwritten Notes
ICSE English Literature Class X Handwritten NotesICSE English Literature Class X Handwritten Notes
ICSE English Literature Class X Handwritten NotesGauri S
 
2.15.24 Making Whiteness -- Baldwin.pptx
2.15.24 Making Whiteness -- Baldwin.pptx2.15.24 Making Whiteness -- Baldwin.pptx
2.15.24 Making Whiteness -- Baldwin.pptxMaryPotorti1
 
mean stack mean stack mean stack mean stack
mean stack mean stack  mean stack  mean stackmean stack mean stack  mean stack  mean stack
mean stack mean stack mean stack mean stackNuttavutThongjor1
 
Data Modeling - Entity Relationship Diagrams-1.pdf
Data Modeling - Entity Relationship Diagrams-1.pdfData Modeling - Entity Relationship Diagrams-1.pdf
Data Modeling - Entity Relationship Diagrams-1.pdfChristalin Nelson
 
50 ĐỀ THI THỬ TỐT NGHIỆP THPT TIẾNG ANH 2024 CÓ GIẢI CHI TIẾT - GIỚI HẠN KHO...
50 ĐỀ THI THỬ TỐT NGHIỆP THPT TIẾNG ANH 2024 CÓ GIẢI CHI TIẾT - GIỚI HẠN KHO...50 ĐỀ THI THỬ TỐT NGHIỆP THPT TIẾNG ANH 2024 CÓ GIẢI CHI TIẾT - GIỚI HẠN KHO...
50 ĐỀ THI THỬ TỐT NGHIỆP THPT TIẾNG ANH 2024 CÓ GIẢI CHI TIẾT - GIỚI HẠN KHO...Nguyen Thanh Tu Collection
 
Evaluation and management of patients with Dyspepsia.pptx
Evaluation and management of patients with Dyspepsia.pptxEvaluation and management of patients with Dyspepsia.pptx
Evaluation and management of patients with Dyspepsia.pptxgarvitnanecha
 
Food Web SlideShare for Ecology Notes Quiz in Canvas
Food Web SlideShare for Ecology Notes Quiz in CanvasFood Web SlideShare for Ecology Notes Quiz in Canvas
Food Web SlideShare for Ecology Notes Quiz in CanvasAlexandraSwartzwelde
 
CONCEPTS OF ENVIRONMENT & ECOSYSTEM.pptx
CONCEPTS OF ENVIRONMENT & ECOSYSTEM.pptxCONCEPTS OF ENVIRONMENT & ECOSYSTEM.pptx
CONCEPTS OF ENVIRONMENT & ECOSYSTEM.pptxAnupkumar Sharma
 
UniSC Fraser Coast library self-guided tour
UniSC Fraser Coast library self-guided tourUniSC Fraser Coast library self-guided tour
UniSC Fraser Coast library self-guided tourUSC_Library
 
Website Fixer-Upper Series to Boost your Online Presence
Website Fixer-Upper Series to Boost your Online PresenceWebsite Fixer-Upper Series to Boost your Online Presence
Website Fixer-Upper Series to Boost your Online PresenceSamantha Russell
 
The Ministry of Utmost Happiness by Arundhati Roy
The Ministry of Utmost Happiness by Arundhati RoyThe Ministry of Utmost Happiness by Arundhati Roy
The Ministry of Utmost Happiness by Arundhati RoyTrushali Dodiya
 

Recently uploaded (20)

2.20.24 The March on Washington for Jobs and Freedom.pptx
2.20.24 The March on Washington for Jobs and Freedom.pptx2.20.24 The March on Washington for Jobs and Freedom.pptx
2.20.24 The March on Washington for Jobs and Freedom.pptx
 
Chromatography-Gas chromatography-Principle
Chromatography-Gas chromatography-PrincipleChromatography-Gas chromatography-Principle
Chromatography-Gas chromatography-Principle
 
Shapley Tech Talk - SHAP and Shapley Discussion
Shapley Tech Talk - SHAP and Shapley DiscussionShapley Tech Talk - SHAP and Shapley Discussion
Shapley Tech Talk - SHAP and Shapley Discussion
 
Overview of Databases and Data Modelling-2.pdf
Overview of Databases and Data Modelling-2.pdfOverview of Databases and Data Modelling-2.pdf
Overview of Databases and Data Modelling-2.pdf
 
BTKi in Treatment Of Chronic Lymphocytic Leukemia
BTKi in Treatment Of Chronic Lymphocytic LeukemiaBTKi in Treatment Of Chronic Lymphocytic Leukemia
BTKi in Treatment Of Chronic Lymphocytic Leukemia
 
2.20.24 Asian Americans and the Myth of the Model Minority.pptx
2.20.24 Asian Americans and the Myth of the Model Minority.pptx2.20.24 Asian Americans and the Myth of the Model Minority.pptx
2.20.24 Asian Americans and the Myth of the Model Minority.pptx
 
UniSC Moreton Bay Library self-guided tour
UniSC Moreton Bay Library self-guided tourUniSC Moreton Bay Library self-guided tour
UniSC Moreton Bay Library self-guided tour
 
first section physiology laboratory.pptx
first section physiology laboratory.pptxfirst section physiology laboratory.pptx
first section physiology laboratory.pptx
 
Diploma 2nd yr PHARMACOLOGY chapter 5 part 1.pdf
Diploma 2nd yr PHARMACOLOGY chapter 5 part 1.pdfDiploma 2nd yr PHARMACOLOGY chapter 5 part 1.pdf
Diploma 2nd yr PHARMACOLOGY chapter 5 part 1.pdf
 
ICSE English Literature Class X Handwritten Notes
ICSE English Literature Class X Handwritten NotesICSE English Literature Class X Handwritten Notes
ICSE English Literature Class X Handwritten Notes
 
2.15.24 Making Whiteness -- Baldwin.pptx
2.15.24 Making Whiteness -- Baldwin.pptx2.15.24 Making Whiteness -- Baldwin.pptx
2.15.24 Making Whiteness -- Baldwin.pptx
 
mean stack mean stack mean stack mean stack
mean stack mean stack  mean stack  mean stackmean stack mean stack  mean stack  mean stack
mean stack mean stack mean stack mean stack
 
Data Modeling - Entity Relationship Diagrams-1.pdf
Data Modeling - Entity Relationship Diagrams-1.pdfData Modeling - Entity Relationship Diagrams-1.pdf
Data Modeling - Entity Relationship Diagrams-1.pdf
 
50 ĐỀ THI THỬ TỐT NGHIỆP THPT TIẾNG ANH 2024 CÓ GIẢI CHI TIẾT - GIỚI HẠN KHO...
50 ĐỀ THI THỬ TỐT NGHIỆP THPT TIẾNG ANH 2024 CÓ GIẢI CHI TIẾT - GIỚI HẠN KHO...50 ĐỀ THI THỬ TỐT NGHIỆP THPT TIẾNG ANH 2024 CÓ GIẢI CHI TIẾT - GIỚI HẠN KHO...
50 ĐỀ THI THỬ TỐT NGHIỆP THPT TIẾNG ANH 2024 CÓ GIẢI CHI TIẾT - GIỚI HẠN KHO...
 
Evaluation and management of patients with Dyspepsia.pptx
Evaluation and management of patients with Dyspepsia.pptxEvaluation and management of patients with Dyspepsia.pptx
Evaluation and management of patients with Dyspepsia.pptx
 
Food Web SlideShare for Ecology Notes Quiz in Canvas
Food Web SlideShare for Ecology Notes Quiz in CanvasFood Web SlideShare for Ecology Notes Quiz in Canvas
Food Web SlideShare for Ecology Notes Quiz in Canvas
 
CONCEPTS OF ENVIRONMENT & ECOSYSTEM.pptx
CONCEPTS OF ENVIRONMENT & ECOSYSTEM.pptxCONCEPTS OF ENVIRONMENT & ECOSYSTEM.pptx
CONCEPTS OF ENVIRONMENT & ECOSYSTEM.pptx
 
UniSC Fraser Coast library self-guided tour
UniSC Fraser Coast library self-guided tourUniSC Fraser Coast library self-guided tour
UniSC Fraser Coast library self-guided tour
 
Website Fixer-Upper Series to Boost your Online Presence
Website Fixer-Upper Series to Boost your Online PresenceWebsite Fixer-Upper Series to Boost your Online Presence
Website Fixer-Upper Series to Boost your Online Presence
 
The Ministry of Utmost Happiness by Arundhati Roy
The Ministry of Utmost Happiness by Arundhati RoyThe Ministry of Utmost Happiness by Arundhati Roy
The Ministry of Utmost Happiness by Arundhati Roy
 

Friability testing

  • 2.  Friability (the condition of being Friable) testing is used to test the durability of tablets during packing processes and transit. This involves repeatedly dropping a sample of tablets over a fixed time, using a rotating drum with a baffle.  In simple words, friability test tells how much mechanical stress tablets are able to withstand during their manufacturing, distribution and handling by the customer.
  • 3.  The friability tests should be performed for compressed, uncoated tablets.  For delayed release tablets, friability is usually controlled on the tablet core prior to the coating operation.  Measurement of tablet friability supplements other physical strength measurements, such as tablet breaking force.
  • 4.  Throughout pharmaceutical industry, friability testing has become an accepted technology and the instrument used in to perform this process is called Friabilator or Friability Tester.
  • 5.  Friability apparatus is having a drum with following characteristics. ◦ Material of construction (MOC): Synthetic Polymer with polished internal surfaces, and subject to minimum static build-up ◦ Internal diameter: Between 283 mm and 291 mm ◦ Depth: Between 36 mm and 40 mm ◦ Inside radius: between 75.5 mm to 85.5 mm ◦ Rotating speed: 25±1 rpm.
  • 8.  Number of tablets to be taken: ◦ Tablets with a unit weight equal to or less than 650 mg: Take sample of whole tablets corresponding as near as possible to 6.5 g. ◦ Tablets with a unit weight of more than 650 mg: Take a sample of 10 whole tablets.
  • 9.  The tablets should be carefully dedusted prior to testing.  Accurately weigh the tablet sample, and place the tablets in the drum.  Rotate the drum 100 times, with a speed of 25 rpm and remove the tablets.  Remove any loose dust from the tablets as before, and accurately weigh.
  • 10.  Calculate the percentage loss of tablet weigh by following formula; (W1 –W2)  Friability (%) =---------------- X 100 W1 Where, W1 = Weight of Tablets (Initial / Before Tumbling) & W2 = Weight of Tablets (After Tumbling or friability) Limit : Friability (%) = Not More Than 1.0 %
  • 11.  Generally, the test is run once.  If obviously cracked, cleaved, or broken tablets are present in the tablet sample after tumbling, the sample fails the test.  If the results are difficult to interpret or if the weight loss is greater than the targeted value, the test should be repeated twice and the mean of the three tests determined.  The maximum mean weight loss from the three samples of not more than 1.0% is considered acceptable for most products.  Effervescent tablets and chewable tablets may have different specifications as far as friability is concened.
  • 12.  If tablet size or shape causes irregular tumbling, the drum base should be adjusted, so that the base forms an angle of about 10° with the bench top and the tablets do not bind together when lying next to each other, which prevents them from falling freely.  An appropriate humidity controlled environment is required for testing of hygroscopic tablets.
  • 13.  Ph.Eur. 2.9.7. Friability of Uncoated Tablets,  JP General Information 26. Tablet Friability Test, and  USP <1216> Tablet Friability