In great details about Vitamin B1 for your dog

1. Vitamin B1 for
Your Pooch

2. Hello!
I am Dr. Preethi Sudarshanie
Dassanayake (B. V. Sc., M. Sc., MBA)
from Veterinary Teaching Hospital,
University of Peradeniya, Sri Lanka.
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3. Vitamin B1 (Thiamine)
⬡ Also known as aneurine.
⬡ Water soluble.
⬡ Sparingly soluble in alcohol.
⬡ Insoluble in fat solvents.
⬡ Stable at acidic solutions.
⬡ Unstable in alkaline solutions.
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4. Thiamine
⬡ Unstable to heat.
⬡ Stable during frozen.
⬡ Unstable when exposed to UV light.
⬡ Is not stored in the body.
⬡ Must be supplied daily.
⬡ Impossible to toxic to your pooch.
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5. Isolation
First isolated from rice bran in
1912 by Casimir Funk.
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6. Robert R. William from US
isolated thiamine in crystalline
form in 1936.
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7. Structure of
Vitamin B1
Consists of an
aminopyrimidine and a
thiazolium ring linked by
methylene bridge.
Formula: C12 H17 N4 O S
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8. Functions of Thiamine
⬡ Supports carbohydrate metabolism.
⬡ Produce energy (ATP).
⬡ Acetyl choline synthesis.
⬡ Transmission of nerve impulses.
⬡ Maintains normal growth.
⬡ It acts as a coenzyme.
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9. Absorption & Transport
Mechanisam of absorption
 Active transport.
 Simple diffusion.
Transport
 After absorption , bind with carrier
plasma protein.
 Through portal vein transported to the
liver.
Absorption
 Precondition for absorption is
presence of sufficient hydrochloric
acid from stomach.
 Phosphoric acid esters of thiamine are
split in the intestine.
 Free thiamine is soluble in water.
 Absorbed in the jejunum.
Thiamine phosphorylation mainly takes place in the liver and forms thiamine pyrophosphate (TPP). Total
body thiamine mainly present as TPP (80%). 10% of total body thiamine present as thiamine
triphosphate (TTP).
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10. Excretion
Mainly by urine. Followed by
faeces.
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11. Causes for Thiamine Deficiency
⬡ Inadequate dietary intake.
⬡ High carbohydrates diet.
⬡ Intestinal diseases (malabsorption)
⬡ Liver diseases (inhibits B1) utilization.
⬡ Prolonged diuretics usage.
⬡ Preservatives in the diet (sulphur dioxide or
sulphite)
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12. In Thiamine deficiency
General
Anorexia
Vomiting
Stunted growth
Loss of hair
coprophagy
Muscular
Kyphosis
Ventroflexion of the
neck
Muscle weakness
Recumbence
Neurological
Seizures
Circling
Exaggerated reflexes
Reduced menace
reflex
Tremors.
Nystagmus.
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13. Requirements NRC (2006)
Pups- 1.38 mg / Kg of diet.
Adults – 2.25 mg /Kg of diet.
1.0 mg / Kg of Feed.
For all life stages of dogs AAFCO (2007) recommendation:
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SOURCES:
Spinach, eggs.
Carrots, broccoli.
Fish, geen peas.
Milk, asparagus.
Peanut butter.
Watermelon.
Eggplant.
Beef, pork, liver.

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Thanks!
Any questions?
You can find me at:
dassanayakepreethi@gmail.com

16. Credits
Special thanks to all the people who made
and released these awesome resources for
free:
⬡ Presentation template by SlidesCarnival
⬡ Photographs by google image.
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