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TOCOPHEROL OR VITAMIN E It is also called anti-aging factor. The word tocopherol is derived from the word tocomeaning ch...
VITAMIN EALPHATOCOPHEROLALPHATOCOTRIENOLHOOHOO
TocopherolsHOOR1R3R2CH3CH3 CH3 CH3CH3R1 R2 R3 Relative activityα – tocopherol CH3 CH3 CH3 1β – tocopherol CH3 H CH3 0.4γ –...
VITAMIN E (Tocopherols)Alpha –tocopherol is the most active formsSOURCES Cottonseed oil Corn oil Sunflower oil Wheat g...
Sources Vitamin E is synthesized only by plants. Plants foods (oils) provide primarysource α -tocopherol in leaves and ...
 Different forms (α, β, γ, δ) , the mostactive form is (α ) Vit E is antioxidant for body fats (unsatlipids), preserve R...
11ABSORPTION small intestine it enters the blood streamvia the lymph.STORAGE  liver &fatty tissueEXCRETION  urine
1. Antioxidant role: Vitamin-E is the most potentnatural antioxidant.2. Removal of Free radicals: Vitamin-E removesfree ra...
3. Protective role: i. Vitamin-E prevents massivehepatic necrosis produced on diet deficient insulphur containing aminoaci...
5. Role in Heme Synthesis: Vitamin-Ealso takes part in the synthesis ofheme. Vitamin-E induces enzymesALA-synthase and ALA...
6. A derivative of vitamin-E is said to benecessary for the synthesis of CoQ which isthe component of mitochondrial electr...
Functions of vitamin E
VITAMIN E Functions & mechanisms of action Antioxidant role Free radical termination Singlet molecular oxygen destruct...
FUNCTIONS REPRODUCTIVE FUNCTION –it has got protective effect on reproduction andprevention of sterility. BLLOD FLOW AND...
 ELECTRON TRANSPORT SYSTEM -it functions as co factor in electron transportsystem
Functions of vitamin E
22 Men 8 – 10 mg Women 5 – 8 mg Children 8.3 mg Infants 4 – 5 mg
DEFICIENCY Muscular dystrophiesNocturnal muscular crampsIntermittent claudicationFibrocystic Breast DiseaseAtherosclerosi...
Deficiency causes: Slow tissue healing Dry hair or loss ofhair Gastrointestinaldiseases Leg cramps Muscular weakness
DEFICIENCY REPRODUCTIVE – abortion of fetus infemales & atrophy of spermatogenic structure inmales leading to permanent s...
ORAL MANIFESTATION – loss of pigmentation , atrophic degenerative changes in enamel Ofvitamin E deficient rat MANAGEMEN...
Misuse No known toxicity up to 3200 IU, though itshould not be taken by those who are allergicto vitamin E. It can eleva...
 Symptoms are dizziness, and headaches. It mayalso cause abdominal pain, diarrhea, fever,chapped lips, muscle aches, naus...
Vitamin E  MUHAMMAD MUSTANSAR
Vitamin E  MUHAMMAD MUSTANSAR
Vitamin E  MUHAMMAD MUSTANSAR
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Vitamin E MUHAMMAD MUSTANSAR

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Vitamin E MUHAMMAD MUSTANSAR

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  3. 3. TOCOPHEROL OR VITAMIN E It is also called anti-aging factor. The word tocopherol is derived from the word tocomeaning child birth and pheros meaning to bear. It is yellow oily liquid freely soluble in fat solvent. Tocopherol alpha, beta, gamma, lambda have beenobtained from the natural sources
  4. 4. VITAMIN EALPHATOCOPHEROLALPHATOCOTRIENOLHOOHOO
  5. 5. TocopherolsHOOR1R3R2CH3CH3 CH3 CH3CH3R1 R2 R3 Relative activityα – tocopherol CH3 CH3 CH3 1β – tocopherol CH3 H CH3 0.4γ – tocopherol H CH3 CH3 0.1 - 0.3δ – tocopherol H H CH3 0.01
  6. 6. VITAMIN E (Tocopherols)Alpha –tocopherol is the most active formsSOURCES Cottonseed oil Corn oil Sunflower oil Wheat germ oil Margarine Green leafyvegetablesRDA: 25-30 IU/day
  7. 7. Sources Vitamin E is synthesized only by plants. Plants foods (oils) provide primarysource α -tocopherol in leaves and other greenparts α -tocopherol in chloroplasts, β, γ, δ-tocopherols (nonchloroplasts) areoutside (soybeans) More vitamin E in green plants
  8. 8.  Different forms (α, β, γ, δ) , the mostactive form is (α ) Vit E is antioxidant for body fats (unsatlipids), preserve RBC from hemolysis ,control metabolism of (PUFA) such aslinoleic (18:2) and linolenic (18:3) . Daily req. 5 IU (infants) & 30 IU (adults).
  9. 9. 11ABSORPTION small intestine it enters the blood streamvia the lymph.STORAGE  liver &fatty tissueEXCRETION  urine
  10. 10. 1. Antioxidant role: Vitamin-E is the most potentnatural antioxidant.2. Removal of Free radicals: Vitamin-E removesfree radicals, prevents their peroxidativeeffects on unsaturated lipids of membrane andthus maintains integrity of membranes.
  11. 11. 3. Protective role: i. Vitamin-E prevents massivehepatic necrosis produced on diet deficient insulphur containing aminoacids.4. Role in reproduction: It is required for normalreproduction, muscle integrity and forresistance of erythrocytes to hemolysis.
  12. 12. 5. Role in Heme Synthesis: Vitamin-Ealso takes part in the synthesis ofheme. Vitamin-E induces enzymesALA-synthase and ALA-dehydratase.
  13. 13. 6. A derivative of vitamin-E is said to benecessary for the synthesis of CoQ which isthe component of mitochondrial electrontransport chain.
  14. 14. Functions of vitamin E
  15. 15. VITAMIN E Functions & mechanisms of action Antioxidant role Free radical termination Singlet molecular oxygen destruction Other roles Vitamin E & heart disease Vitamin E & eye health Other conditions
  16. 16. FUNCTIONS REPRODUCTIVE FUNCTION –it has got protective effect on reproduction andprevention of sterility. BLLOD FLOW AND CLOTTING MECHANISM –it dilates the capillaries & enables the blood toflow freely.
  17. 17.  ELECTRON TRANSPORT SYSTEM -it functions as co factor in electron transportsystem
  18. 18. Functions of vitamin E
  19. 19. 22 Men 8 – 10 mg Women 5 – 8 mg Children 8.3 mg Infants 4 – 5 mg
  20. 20. DEFICIENCY Muscular dystrophiesNocturnal muscular crampsIntermittent claudicationFibrocystic Breast DiseaseAtherosclerosis Hemolytic anemia- susceptibility ofRBCs to hemolysis Dietary hepatic necrosis Neurological disorders
  21. 21. Deficiency causes: Slow tissue healing Dry hair or loss ofhair Gastrointestinaldiseases Leg cramps Muscular weakness
  22. 22. DEFICIENCY REPRODUCTIVE – abortion of fetus infemales & atrophy of spermatogenic structure inmales leading to permanent sterility. HEART - there is necrosis & fibrosis of heartmuscle. BLOOD CAPILLARIES – may lead todegenerative changes in the blood capillaries
  23. 23. ORAL MANIFESTATION – loss of pigmentation , atrophic degenerative changes in enamel Ofvitamin E deficient rat MANAGEMENT –vitamin E is given in the doses of 100 to400mg.
  24. 24. Misuse No known toxicity up to 3200 IU, though itshould not be taken by those who are allergicto vitamin E. It can elevate blood pressure when first taken,so those with high blood pressure or heartdisease should not take more than 200 IU vitamin E may cause blood clots iftaken in doses above 800 lU/day.
  25. 25.  Symptoms are dizziness, and headaches. It mayalso cause abdominal pain, diarrhea, fever,chapped lips, muscle aches, nausea, upsetstomach, fatigue, weakness, and blurred vision,though these are rare. Allergies can also occur when vitamin E is usedin skin preparations, but these are extremely rare.

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