3. Pharmacokinetics
Pharmacokinetics is the quantitative study of the drug movement in through
and out of the body.
The intensity of the action of any drug is related to its concentration at the
site of action, which depends on the Pharmacokinetic properties of that drug.
Therefore,Pharmacokinetics determine the routes of administration.
4. Absorption, Distribution, Metabolism,
Excretion
Absorption is the study of movement from its site of administration into the
circulation.
Distributionn, after reaching to the blood stream drug get distributed to the
other tissues that initially har no drug.
Metabolismm, biochemical conversion of the drug into another chemical
form.
Excretion, is the elimination of the systemically absorbed drug.
6. Importance of Pk in Drug Development
A major cause of failure of orall drugs during their development is the
discovery that in humans they have low intestinal absorption and/or high
clearance causing low and variable bioavailability.
Pk studies are important for the assessment of the bioavailability, half-life,
metabolic properties, clearance profile of a given drug compound.
Some drugs shows high activity in in-vitro but in in-vivo doesn’t show the
same activity or show high toxicity, this alteration or toxic effect can be
understand by the Pharmacokinetic studies.
7. Importance of Pk in Drug Development
With poor pharmacokinetics it can be difficult to achieve a suitable dosage regimen for the
required pharmacodynamic action.
PK studies in drug discovery is to screen multiple compounds, evaluate their
intrinsic DMPK properties, and then perform additional metabolism studies
to proceed to drug development. Therefore, an understanding of drug
candidate metabolic profiles is essential to the selection of compounds with
desirable DMPK properties in early drug discovery.
Therefore, the study of pharmacokinetics and metabolism is essential.
8. Reference
Essentials of Medical Pharmacology, K.D. Tripathi, Jaypee Prakashan.
Biopharmaceutics and Pharmacokinetics The Treaties by D.M. Brahmankar &
Sumit B. Jaiswal, Vallabh Prakashan.
https://www.bruker.com/applications/pharma-biopharma/drug-
discovery/adme-toxicology/dmpk.html
https://pubmed.ncbi.nlm.nih.gov/12682673/