Please read.

1. Introduction of Biopharmaceutics
and Pharmacokinetics

2. Biopharmaceutics
Biopharmaceutics is the science that deals with
the relationship among the drug physicochemical
properties, the dosage form characteristics, the
route of drug administration, and the availability
of the drug to the site of drug action.

3. Pharmacokinetics
Pharmacokinetics is the study of the kinetics of
drug absorption, distribution, and elimination.
Elimination=Metabolism+Excretion.
ADME
“What body does to the drug.”

4. Clinical Pharmacokinetics
Clinical pharmacokinetics is the field of applying
the basic pharmacokinetic principles in the
individualization of drug therapy.

5. Pharmacodynamics
The branch of pharmacology concerned with the
effects of drugs with respect to dose and the
mechanism of their action.
“What drug does to the body”

6. APPLICATION OF BIOPHARMACEUTIC
AND PHARMACOKINETIC PRINCIPLES
• Drug formulation design
• Drug dosage form design
• Pharmacological testing
• Toxicological testing
• Evaluation of organ function
• Dosage regimen design

7. Plasma concentration-time profile

8. Linear Pharmacokinetics
Also known as dose independent
pharmacokinetics. It discusses pharmacokinetic
parameters which is not a function of drug dose.

9. Non-linear Pharmacokinetics
Also known as dose independent
pharmacokinetics. It discusses pharmacokinetic
parameters which is not a function of drug dose.

10. Pharmacokinetic Modeling
• Compartmental models
• Physiologic models
• Non-compartmental approach