The document discusses the mucosal immune system and the role of IgA antibodies. It defines the mucosal immune system and how it differs from cutaneous immunity. IgA is produced in mucosal tissues and transported through epithelial cells to act as a first line of defense against pathogens. IgA deficiency is also discussed, noting that while prevalent, it is often asymptomatic but can cause infections in symptomatic cases due to immune dysfunction.

1. “ Mucosal Immune System, &
the Role of IgA in the Mucosal
Immunity ”
Muhammed Al Bashir
MBBS student
at SulaimanAlRajhiUniversity
@M7mdAlBashir

2. 1) Mucosal Immune System
• Definition
• Deference between it and the
cutaneous immune system.
• commensal organisms

3. • Composition & 3 examples
• Quantity of lymphocytes
• Why not react with
commensal organisms

4. 2) Role of IgA in the Mucosal
Immunity
• Site of
production, course, &
site of action
• Another name
• Percentage of IgA
• Why B cells in
mucosal epithelial
tissues produce IgA
• B-1 cells
• Intestinal mucosal B
cells location
• Transport through the
epithelium, protease,
secretory component
• poliovirus infection

5. 3) IgA Deficiency
• Prevalence
• Serum &
secretory
• Symptomatic-
e.g- &
asymptomatic
• What makes
symptomatic
• The basis
(cytokine, BAFF)

6. @M7mdAlBashir
ThanQAny ?