Targeted drug delivery, also known as smart drug delivery, is a method of treatment that involves the increase in medicament in one or few body parts in comparison to others.

1. PRESENTATION ON
TARGETED DRUG DELIVERY
SYSTEM USING
NANOPARTICLES
And abide in your houses and do not display yourselves as
[was] the display of the former times of ignorance. And
establish prayer and give zakah and obey Allah and His
Messenger. Allah intends only to remove from you the
impurity [of sin], O people of the [Prophet's] household, and
to purify you with [extensive] purification [33. Al-Ahzab:33].

2. CONTENTS :
• Introduction
• Advantages
• Disadvantages
• Classifications of Nanoparticles
• Applications
• Nano Drug Delivery For Anticancer Agents
• Mode of Action
• Methods of Preparation
• Factors Affecting Nanoparticles
• Conclusion

3. INTRODUCTION :
• Targeted drug delivery, also known as smart drug delivery, is a
method of treatment that involves the increase in medicament
in one or few body parts in comparison to others.
• Therefore, it delivers the medication only to areas of interest
within the body.
• Passive targeting : Drug delivery systems which are targeted to
systemic circulation and based on the accumulation of drug at
areas around the site of interest, such as in case of tumor tissues
is called passive targeting.
• Active targeting : In this approach carrier system bearing drug
reaches to specific site on the basis of modification made on its
surface rather than natural uptake. It works through the use of
ligand-receptor interactions.

4. INTRODUCTION CONT….
• To improve the pharmacokinetic and pharmacodynamics activity of the
drug medication system like nanoparticles has made a break through by
means of physical application.
• Nanotechnology is the science which deals with small; the very small
particles.
• Through novel drug delivery systems various drugs can be delivered to the
desired (specific) sites showing its pharmacological activity by
minimizing side effects.
• Nanostructures have the ability to cross the cell and tissue barriers as its
particle size is very small which makes them widely applicable in
biomedical sciences.

5. ADVANTAGES :
• The Novel drug delivery system (Nanoparticles) is used to
deliver drugs through oral, nasal, parenteral, intra-ocular etc.
• Through nanoparticles particle size can be easily altered
resulting in attaining both active and passive drug targeting
after parenteral administration
• Nanoparticles have the ability to control and sustain the drug
before reaching the specific site of action and protects drug
from rapid degradation and maintains drug concentration at
specific sites or in target tissues
• One more important advantage of nanoparticles is high levels
of drug can be incorporated without any chemical reaction
resulting in the preservation of pharmacological activity of the
drug
• It avoids hepatic first pass metabolism.
• Reduces in the frequency of the dosages taken by the patient.

6. DISADVANTAGES :
• In spite of many advantages nanoparticles have some
limitations which make researches to work more on it to
attain even more best therapeutic efficacy with lesser side
effects.
• Aggregation of particles may takes place due to its altered
physical properties especially in liquid and dry forms
because of its smaller particle size and larger surface area.
• Due to its particle size (smaller) and larger surface area
nanoparticles are very reactive in the cellular environment .

7. CLASSIFICATION OF
NANOPARTICLES:

8. APPLICATIONS :

9. NANODRUG DELIVERY
SYSTEMS FOR ANTI-
CANCER AGENTS :Anticancer agents Mode of action Findings
Paclitaxel Stabilize the drug particle
And prevents any risk of
Obstruction.
Help endothelial
transcystosis
Of protein bound and
unbound plasma
constituents.
Pluronics Interact with multidrug
Resistant cancer cells
Drastic sensitization of
cancer cells.
Endostatin Inhibit the growth of a
variety of human tumor
by inhibiting
neovascularization
Expensive, thus limits their
clinical application.
Osteonectin Present in some neoplasms,
Leading to the
accumulation
Of albumin in some tumors
Facilitate tumor
accumulation of albumin
bound drugs.

10. MODE OF ACTION :

11. METHODS OF
PREPARATION

12. FACTORS AFFECTING
NANOPARTICLES:
• Particle size : Smaller particles have a larger surface area-to-volume
ratio; therefore, most of the drug associated with small particles would be
at or near the particle surface, leading to faster drug release. In contrast,
larger particles have large cores, which allow more drug to be encapsulated
per particle and give slower release. Thus, control of particle size provides
a means of tuning drug release rates.
• Drug loading : A successful nanodelivery system should have a high
drug-loading capacity, thereby reducing the quantity of matrix materials
for administration.
• Drug Release : In the case of nanospheres, where the drug is uniformly
distributed, drug release occurs by diffusion or erosion of the matrix. If the drug
is loaded by the incorporation method, then the system has a relatively small
burst effect and sustained release characteristics .

13. FACTORS AFFECTING
CONT…..
• Surface Properties of Nanoparticles :
Hydrophobicity influences the in vivo fate of nanoparticles.
Indeed, once in the blood stream, surface non-modified
nanoparticles (conventional nanoparticles) are rapidly
opsonized and massively cleared by the Mononuclear
Phagocyte System (MPS).To increase the likelihood of
success in drug targeting, it is necessary to minimize the
opsonization and prolong the circulation of nanoparticles in
vivo.

14. CONCLUSION :
• Nanotechnology is truly a multidisciplinary science where
chemists, physicist, biologists and pharmaceutical scientist
all have played major roles to develop novel treatment and
diagnosing modalities.
• It is evident through this review that application of
nontechnology in drug delivery and medicine has paved new
pathways and opened many doors for providing
customizable and safer treatment option.
• The treatment of cancer and HIV/AIDS, non-invasive
imaging as well as nutraceutical delivery have all progressed
with the application of nanotechnology. Ultimately, through
the manipulation of molecular size and surface properties,
researchers are able to deliver drugs for longer period of
time with less frequent dosing (sustained release) and with