Nanoparticle Drug Delivery Systems Explained
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Advantages of targeted drug delivery system
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Nanoparticle Drug Delivery Systems Explained
- 1. Nanoparticle in Drug Delivery System (NDDS) By: Hashem Ghezelsofla
- 2. 2 Drug delivery systems Nanoparticle in Drug Delivery System
- 3. 3 Drug levels in the blood with (a) traditional drug dosing and (b) controlled-delivery dosing Advantages of targeted drug delivery system Nanoparticle in Drug Delivery System
- 4. Nanoparticles as a drug delivery system Nanoparticle in Drug Delivery System
- 5. Magnetic Drug Targeting (MDT) Magnetic Targeted Carriers (MTC) Nanoparticle in Drug Delivery System
- 6. application of magnetic nanoparticles in medicine Diagnosis Invitro Bio-Sensing Cell separation Transfection Biological separation Enzyme stabilizationInvivo MRI Therapy Drug delivery Hyperthermia Magnetic nanoparticles are used for a wide range of clinical applications Nanoparticle in Drug Delivery System
- 7. Nanoparticle in Drug Delivery System
- 8. Magnetic nanoparticles in drug delivery Nanoparticle in Drug Delivery System Particle size 3-30 nm Particle size distribution 10-20% Dissolved in water Dextran Kitosan
- 9. Magnetic nanoparticles in medical applications Nanoparticle in Drug Delivery System
- 10. Processes of magnetic particles preparation for drug delivery Nanoparticle in Drug Delivery System
- 11. Methods for Magnetic Nanoparticles (MNPs) Synthesis Reduction Copercipitation Reverse microemulsion polyol Thermal Decomposition Sonochemical Hydrothermal Microwave Nanoparticle in Drug Delivery System
- 12. Copercipitation method Nanoparticle in Drug Delivery System
- 13. Reverse microemulsion synthesis method Nanoparticle in Drug Delivery System
- 14. Polyol synthesis method Nanoparticle in Drug Delivery System
- 15. Thermal decomposition method Nanoparticle in Drug Delivery System
- 16. Design of nanoparticles for bioapplications Biocompatibility Size (10- 20 nm) Secretion (PEG) Stable Nanoparticle in Drug Delivery System
- 17. Methods for Magnetic Nanoparticle Synthesis and Functionalization Insitu Post synthetic coating Direct exchange Ligand exchange Nanoparticle in Drug Delivery System
- 18. Characterization techniques for nanomaterials (XRD) X-ray diffraction DLS (dynamic light scattering) zeta potential VSM(vibrating-sample magnetometer) Squid magnetometer IR Spectroscopy TEM (Transmission electron microscopy) TGA (Themal Gravimetry Analysis) XPS (X-ray photoelectron spectroscopy) Mössbauer spectroscopy Nanoparticle in Drug Delivery System
- 19. XRD (X-ray diffraction) DLS (dynamic light scattering) Zeta potential Nanoparticle in Drug Delivery System
- 20. VSM (vibrating-sample magnetometer) Squid magnetometer Nanoparticle in Drug Delivery System
- 21. TGA(Themal Gravimetry Analysis) XPS (X-ray photoelectron spectroscopy) Mössbauer spectroscopy Nanoparticle in Drug Delivery System
- 22. Targeted Drug Delivery Passive Targeting EPR(enhanced permeability and retention) Physical features Nano carrier size linkage Localised delivery Active Targeting Antibodies Ligands Aptamers Nanoparticle in Drug Delivery System
- 23. Nanoparticle–biomolecule conjugate Nucleic acids antibody Peptides Proteins Phospholipides Carbohydrates Hormons aptamer Nanoparticle in Drug Delivery System
- 24. Targeted drug delivery agents Nanoparticle in Drug Delivery System
- 25. Applications of Magnetic Nanoparticles in Targeted Drug Delivery System Magnetic nanoparticles as the nucleus for delivering targeted drugs A High Field Gradient Magnet for Magnetic Drug Targeting Enzyme-responsive nanoparticles for drug release change in thephysiological condition (PH- Temperature) MRI Nanoparticle in Drug Delivery System
- 26. Applications of Magnetic Nanoparticles in Targeted Drug Delivery System Hyperthermia directed specifically to cancer cells through the use of magnetic nanoparticles heated with alternating magnetic fields has been used as a novel cancer therapy Nanoparticle in Drug Delivery System
- 27. Nanoparticle in Drug Delivery System
- 28. Magnetic Assisted Transfection Nanoparticle in Drug Delivery System
- 29. Magnetically-triggered drug release system. Schematics of nanoparticles, molecular machines, assembly and remote- controlled drug release. The particles and machines are not drawn to scale (reproduced with permission from [142], Copyright 2010, American Chemical Society). Druge release + Hyperthermia Nanoparticle in Drug Delivery System
- 30. Conclusions 30 • Improve the medicinal and therapeutic properties • Transfer the drug to a specified amount • Transferring medicine to a specific place in the body • The effects of medications and the distribution of medicine in the body The ability to control the movement of magnetic particles in the body is possible using an external magnetic field. Due to their low toxicity, these particles are used in various branches, including medicine, MRI and hyperthermia and gene therapy and DNA transducer. Nanoparticle in Drug Delivery System