In this include brain targeted drug delivery we can see that in a brain there are a barrier it is known as blood brain barrier. so how we can cross those barrier is a important discussion for us to target the drug in brain.

1. DEPARTMENT OF PHARMACY
GURU GHASIDAS VISHWAVIDYALAYA
PRESENTATIONON
ROLE OF NANO-PARTICLE IN BRAIN TARGETED DRUG DELIVERY
SUBMITTED BY
PRABHAT DEWANGAN
M. PHARM 1ST (PHARMACEUTICS)

2. CONTENT:
Introduction
Role of nanoparticles in brain specific delivery
Mechanism for transport
Advantage
Limitations

3. INTRODUCTION:
• The treatment of brain disease ( Parkinson’s, Epilepsy, Meningitis ) is a
complex and limited due to the presence of blood brain barrier.
• The BBB protecting brain from harmful substances but it is metabolic barrier
and transport regulator of nutrient and because of this reason brain delivery
system mostly based on nanotechnology.
• Nanoparticles drug delivery system is one of the advanced technology that
can be utilized to deliver drug molecules directly into the brain and proved
to be very effective against several CNS disorders.
• Nanoparticle mainly reduce side effect increase drug concentration in the

4. site of action therefore increase therapeutic effect.
ROLE OF NANOPARTICLE IN BRAIN SPECIFIC DELIVERY:
The nanoparticles as a targeting drug delivery system may include,
• The particle size ranging from 1 to 100 nm, having ability to target particular
organ or tissue.
• Having property of hydrophobicity and lipophilicity are made up of
biocompatible and biodegradable polymers.
There are different types of nanoparticles,
1. Nano-spheres 2. Nano-capsules

5. MECHANISM FOR TRANSPORT:
• The mechanism for transport of lipoprotein to be endocytosis via the low
density lipoprotein.
• Receptor of the endothelial cells after adsorption of lipoproteins from blood
plasma to the nanoparticles.
• It is suggested that the recognition and interaction with lipoprotein
receptors on brain capillary endothelial cells is responsible for the brain
uptake of the drug.

6. ADVANTAGE OF USING NANOPARTICLES FOR CNS TARGETED DRUG DELIVERY SYSTEM:
• Nanoparticles protect drugs against chemical and enzymatic degradation.
• Due to their small size nanoparticles penetrate into even small capillaries
and are taken up within cells, allowing an efficient drug accumulation at the
targeted sites in the body degradation.
• The use of biodegradable materials for nanoparticles preparation, allows
sustained drug release at the targeted site after injection over a period of
days or even weeks.
• They are also able to reduce side effects of some active drugs.

7. LIMITATION FOR USING NANOPARTICLES FOR CNS TARGETED DRUG DELIVERY:
• Their small size and large surface area can lead to particle- particle
aggregation, making physical handling of nanoparticles difficult in liquid and
dry forms.
• In addition, small particles size and large surface area readily result in
limited drug loading and burst release.

8. Thankyou
REFERENCE:
• A. Misra, S. Ganesh, A. Shahiwala, and S.P. Shah, "Drug delivery to the central nervous system: a review", J Pharm
Pharm Sci, Vol. 6, pp. 252-73,2003.
• W. M. Pardridge, "Blood-brain barrier drug targeting: the future of brain drug development", Molecular
interventions, Vol. 3, pp. 90,2003.
• R. Singh and J.W. Lillard, "Nanoparticle-based targeted drug delivery", Experimental and molecular pathology, Vol.
86, pp. 215- 223,2009.