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Dna repair
- 1. DNA REPAIR JENIFER LÓPEZ ECHEVERRY MEDICINE ESTUDENT PONTIFICAL BOLIVARIANA UNIVERSITY III SEMESTER
- 4. When the repair fails and the cell does not suffer apoptosis or senescence, it is important to make an external intervention to develope mechanisms to supply the disbalance between mutations/reparations INTRODUCTION
- 5. Johannes Gutenberg Universitaet Mainz. (June 30, 2017). How telomeres protect cells from premature senescence.
- 6. HOW TELOMERES PROTECT CELLS FROM PREMATURE SENESCENCE Over a cell's lifetime, telomeres get gradually shorter with each cell division and therefore the protective cap becomes less and less effective Stop division Older cell links
- 7. HOW TELOMERES PROTECT CELLS FROM PREMATURE SENESCENCE TERRA is an RNA species that accumulates specifically at the ends of critically short telomeres by binding directly to the DNA Signal to repair
- 8. HOW TELOMERES PROTECT CELLS FROM PREMATURE SENESCENCE • Rat1 and RNase H2 proteins bind preferentially to the long telomeres and ensure that TERRA is removed, but they are not present at the critically short telomeres.
- 9. STUDENT OPINION I think this new is so important. If scientists could apply this researches to human cells we would be in front of a possible cure of cancer and cells aging.
- 10. Stowers Institute for Medical Research. (June 22, 2017). Cancer cells may streamline their genomes in order to proliferate more easily
- 11. CANCER CELLS MAY STREAMLINE THEIR GENOMES IN ORDER TO PROLIFERATE MORE EASILY • The investigator saw a loss of ribosomal DNA copies in the cancer cells relative to the normal cells. The DNAr is a DNA sequence that codes for RNAr.
- 12. CANCER CELLS MAY STREAMLINE THEIR GENOMES IN ORDER TO PROLIFERATE MORE EASILY • The cells somehow managed to be highly proliferative, made more ribosomal RNA, and synthesized more protein, all with fewer copies of ribosomal DNA.
- 13. CANCER CELLS MAY STREAMLINE THEIR GENOMES IN ORDER TO PROLIFERATE MORE EASILY • He speculate less DNA to copy promotes proliferation but that is very sensitive to DNA damage
- 14. STUDENT OPINION I think this finding shows the DNAr important role in proliferation and that could be a therapeutic target.
- 15. MEDICAL UTILITY
- 16. MEDICAL UTILITY Both researches shows the proliferation importance and possible investigations objetives.
- 17. MEDICAL UTILITY • The importance of DNA repair is evident in both news so if this mechanism is efficient not only stops wrong proliferation but also the aging.
- 18. MEDICAL UTILITY • The importance of DNA repair is also demonstrated by the increased rate of mutation that follows the inactivation of a DNA repair gene.
- 19. BIBLIOGRAPHY ✓Stowers Institute for Medical Research. (June 22, 2017). Cancer cells may streamline their genomes in order to proliferate more easily. ScienceDaily. https://www.sciencedaily.com/releases/2017/06/170622142959.h tm ✓Johannes Gutenberg Universitaet Mainz. (June 30, 2017). How telomeres protect cells from premature senescence. ScienceDaily. https://www.sciencedaily.com/releases/2017/06/170630105013.h tm ✓Martinez Sanchez, Lina Maria. Biologia molecular.8.ed.Medellin: UPB.Fac.Medicina.