Folding Aleja Ramírez


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Folding Aleja Ramírez

  1. 1. METHOD OF DNA REPAIR LINKED TO HIGHER LIKELIHOOD OF GENETIC MUTATION AND UNLOCKING THE SECRETS OF DNA <br />Mª Alejandra Ramirez Ruiz <br />Medicine Student <br />3rd Semester<br />
  2. 2. FOLDING<br />
  3. 3. FOLDING<br />
  4. 4. INTRODUCTION<br />
  5. 5. Method of DNA repair linked to higher likelihood of genetic mutationScienceDaily (Feb. 15, 2011)<br />
  6. 6. Method of DNA repair linked to higher likelihood of genetic mutation<br />A method by which cells repair breaks in their DNA, known as Break-induced Replication (BIR), is up to 2,800 times more likely to cause genetic mutation than normal DNA synthesis. <br />Representation of a DNA ligase repairing double-stranded <br />
  7. 7. Method of DNA repair linked to higher likelihood of genetic mutation<br />When BIR occurs, instead of using a "band aid" to repair, the broken piece invades another chromosome and initiates replication which happens at the wrong place and at the wrong time.<br />When the cell use this method accuracy is lost. <br />Dna Damage<br />
  8. 8. Method of DNA repair linked to higher likelihood of genetic mutation<br />There are at least four changes to the replication machinery that might occur to create a perfect storm or synergy that make BIR repair so mutagenic, and the mutagenesis caused occurs in surges.<br />This study could help to prevent mutations that can cause cancer.<br />Cancer cells<br />
  9. 9. OBSERVATION<br />Contrary to the common idea that all repair mechanisms are beneficial, the BIRrepair system brings fatal consequences in the replication process generated by an excess concentration of nucleotides.<br /> <br />It is clear that not all mutations are harmful because evolutionary processes also occur as a result.<br />
  10. 10. Unlocking the Secrets of DNAScienceDaily (Jan. 28, 2011)<br />
  11. 11. Unlocking the Secrets of DNA<br />Neutron scattering gives information about the correlation between base pairs during denaturation, which is not possible using other techniques. <br /><ul><li>It is used to measure the characteristic size of the denatured regions as the temperature is changed</li></ul>DNA components: Form and structure determination by neutron scattering<br />
  12. 12. Unlocking the Secrets of DNA<br />A range of temperatures, will cause that the bonds between base pairs break, or denature, causing the two strands of DNA to separate.<br />The experiment could only measure the first stage: when the strands become 50% denatured they are too floppy to remain ordered. The DNA sample literally falls to pieces.<br />
  13. 13. Unlocking the Secrets of DNA<br />The experiment follows from the pioneering work of Rosalind Franklin, who showed that x-ray scattering from DNA fibres would give structural information. Based on her work, James Watson and Francis Crick deduced the well-known double helix structure of DNA in 1953.<br />James Watson and Francis Crick <br />
  14. 14. OBSERVATION<br />The use of advanced techniques for the study of DNA, allows to continuous learning about the most important molecule in molecular biology. <br /> <br />Know in detail the formation and operation brings great advances, not only in the field of medicine, but also in the developing world of technology and information.<br />
  15. 15. MEDICAL UTILITY<br />
  16. 16. MEDICAL UTILITY<br />Understand the workings of DNA allows for breakthroughs in medical issues such as genetic recombination, inheritance, mutations, congenital diseases, repair mechanisms, among others. <br />
  17. 17. MEDICAL UTILITY<br />Knowing the molecule that contains all the genetic information is like deciphering the map of life.<br />Find different mechanisms to counteract the effect of diseases that have a direct attack in the genome<br />M<br />E<br />A<br />N<br />S<br />
  18. 18. MEDICAL UTILITY<br />It’s useful to employ new techniques to investigate the genome, and also explore some mechanisms of the cell that can go against their preservation. <br />Science can develop strategies about them and could act against which represents a major threat human such as cancer. <br />
  19. 19. BIBLIOGRAPHY<br />MARTINEZ S., Lina María. Biología molecular. 6. ed. Medellín : UPB. Fac. de Medicina,  2009. 56 p. <br />Public Library of Science (2011, February 15). Method of DNA repair linked to higher likelihood of genetic mutation. ScienceDaily. Retrieved February 19, 2011, from<br />Institut Laue-Langevin (ILL) (2011, January 28). Unlocking the secrets of DNA. ScienceDaily. Retrieved February 18, 2011, from­ /releases/2011/01/110124120848.htm<br />
  20. 20. ¡THANKS!<br />