4. The main purpose of DNA
replication is to preserve the
genetic information
Enzymes involved in this
process, ensure the integrity
of the information. Any
enzymatic mutation can
cause a genomic damage.
5. “Forks colliding: How DNA breaks
during re-replication”
Whitehead Institute for Biomedical Research
(2015, June 4)
With this new system, Orr-Weaver and her
lab can begin to isolate the individual
components involved in the repair pathways,
resolve their precise roles, and perhaps
determine whether other genomic locations
are involved in the process.
6. The investigation was
done with Drosophila
ovarian follicle cells
because this is a unique
cell type whose DNA
replication is tightly
regulated during
organismal development.
“Forks colliding: How DNA breaks during re-replication”
9. “Forks colliding: How DNA breaks during re-
replication”
STUDENT’S
OBSERVATION
Research such as this are very
important, because knowing the
cleavage sites of double -strand
breaks and how cells try to repair
the damage, science will have more
and more elements to regulate
DNA replication or failing to repair
damage to this process , avoiding
thus the proliferation of malignant
cells as in the case of cancer .
10. “Bacteria use DNA replication to time
key decision”
Rice University
(2015, July 9)
Successful sporulation requires two complete copies of the
bacterial chromosome, so coordination between the
sporulation decision and the completion of DNA
replication is very important.
If the organism waits too long, it
can starve before it finishes
transforming into a spore. If it
acts too early and forms a spore
too soon, it can be overwhelmed
and out-reproduced by
competitors.
11. “Bacteria use DNA replication to time key decision”
If food gets scarce, B. subtilis must
decide between two possible paths:
shut down, form a dormant spore
"sporulation" and wait for better
times or split into two cells and
gamble that there is enough food for
at least one more generation.
12. “Bacteria use DNA replication to time key decision”
Spo0F excess inhibits the Kina activity
through negative feedback ,which
means the circuit output works to
counteract the input that triggers it.
This ensures a relatively constant cycle
13. “Bacteria use DNA replication to time key decision”
The location of the KinA and Spo0F
genes is crucial because If one were
located near the point where DNA
replication began, the cell would
contain two copies of that gene,
throughout the DNA replication
period but If the other gene were
located on the part of the circle
that was copied last, the ratio of
KinA to Spo0F would be one-to-
one only when DNA replication
was nearly completed.
14. “Bacteria use DNA replication to time key decision”
STUDENT’S
OBSERVATION
I think that research like this, are very
important because knowing the
mechanism by which more than 30
species of bacteria coupled DNA
replication cycle in a critically form and
to favor of one or another, gives
benefits to current science to develop
new modifications of this type of
bacteria that represent a risk to
human health and to bring him big
impact; offering him greater quality in
him health.
16. Thanks to the replication of
DNA, genetic information can
be passed from one species
another , retaining typical
features to recognize and
differentiate one organism
from another
Medical Utility
17. Medical UtilityMedical Utility
Knowing carefully how DNA
replication occurs in researches as
these, These and new scientific have
more facilities to recognize
mutations or incorrect transmission
of genetic material and thus can act
more promptly.
18. Reproduction of cancer cells, in most
cases , is given by poor replication. Now,
with these new scientific advances , the
cure for cancer or a less invasive
treatment , is getting closer with the help
of genetics
The bacteria pose a serious threat to
human health . By knowing how the
cell cycle is given , medicine may
intervene easier in their development
and reproduction and thus lessen
frequent infections and bacterial
colonization
Medical Utility
19. BIBLIOGRAPHYBIBLIOGRAPHY
Whitehead Institute for Biomedical Research.
(2015, June 4). Forks colliding: How DNA breaks
during re-replication. ScienceDaily. Retrieved
August 1, 2015 from http://
www.sciencedaily.com/releases/2015/06/15060414152
Rice University. (2015, July 9). Bacteria use DNA
replication to time key decision. ScienceDaily.
Retrieved August 1, 2015 from http://
www.sciencedaily.com/releases/2015/07/15070916242
Martinez Sánchez, Lina María. Biología Molecular.
7.ed. Medellín: UPB. Fac. Medicina, 2015. 101-115
p
