The excretory system, including the urinary system, removes waste from the body. The kidneys filter blood and remove wastes, regulating fluid levels. The hypothalamus monitors fluid levels and signals the kidneys. The kidneys contain nephrons that filter blood, removing wastes and excess water into urine. Urine exits the kidneys and is stored in the bladder before leaving the body. Disease can occur if wastes build up due to issues with the urinary system. Dialysis is needed if both kidneys fail to filter blood.