A extremoChem is a start-up company aiming at the development and commercialisation of chemically synthesised novel excipients for the stabilisation of biologics.

1. 3 R D F E B R U A R Y 2 0 1 6

2. Team
• Founders:
- Rita Ventura
- Eva Lourenço
- Christopher Maycock
- Based on 15 years of academic research
• Business development team:
- Pedro Vilarinho, COTEC Portugal
- Filipe Aguiar, 73100 – Infraventus
- Founded on November 2013
- Investor: Setenta e Três Mil e Cem, Lda.

3. ExtremoChem is a start-up company aiming at the
development and commercialisa=on of chemically
synthesised novel excipients for the stabilisa=on of
biologics.

4. Problem/Opportunity

5. Problem/Opportunity
Ac=ve Protein Inac=ve Protein
Heat and cold
pH stress
Shaking

6. Current solu=on: cold chain
CerSfied container
Distributors
Current solu=on issues:
temperature excursions
Degrada=on - loss of efficacy and safety
Manufacturer
s
Pa=ent

7. “Improved thermostability of
vaccines is an area of interest for
us”
Senior Director External ScienSfic Affairs,
Merck & Co., USA
Market need

8. Our solu=on
Archaeoglobus fulgidus
Hydrothermal vents
• Chemically synthesised analogues of protein
stabilising natural compounds with improved
stabilisaSon properSes

9. Our solu=on
STABILISATION OF BIOPHARMACEUTICALS
Ac=ve Protein Ac=ve Protein
Chemical Compound
Heat and cold
pH stress
Shaking

10. Value Proposi=on
Synthesis of new compounds for stabilisaSon of
biopharmaceuScals over a wider range of
temperatures
PHARMACEUTICAL
INDUSTRY
Biopharmaceu=cals efficacy and safety
guaranteed all over the world
• The costs of cold chain failure are esSmated to be €5b

11. • Spin-off of the Imperial College London, 2007
• Excipient mixture derived from seeds and customised
to each vaccine - under tesSng
• Private company based in Cambridge, Massachuse]s,
founded in 2001
• Liposome encapsulaSon of vaccine - under clinical
trials
Compe==on

12. Development status
ü Caninsulin – Porcine insulin, for veterinary use
ü Lantus, Humulin Regular, Actrapid, Insuman Rapid,
Insuman Basal, Humulin NpH, Insulatard - Human
Insulin
ü Cervarix and Gardasil – Human papiloma virus vaccine
ü Erythropoie=n – Human, recombinant, CHO cells
ü Norditropin SimpleXx – Somatropine, human growth
hormone
ü Humira – monoclonal anSbody, autoimune diseases
• Stabilisa=on of commercially available biopharmaceu=cals in
the presence of ExtremoChem compounds

13. Development status
• StabilisaSon of biopharmaceuScals at room temperature
up to 45 days in the presence of ExtremoChem
compounds
• PrevenSon of biopharmaceuScal aggregaSon caused by
pH stress and shaking - improvement of produc=on
yields in the presence of ExtremoChem compounds
• Degrada=on of the proteins without added compounds
• The biological ac=vity of the tested proteins in the
presence of our compounds remained the same

14. IP Protec=on
• US Patent submiWed during 2014: Hexose
deriva4ves, prepara4on and uses thereof
• IP Legal advisers: Cooper & Dunham LLP – New
York
• PCT applicaSon under preparaSon
• New IP under prepara=on

15. Business model
• Co-development for each different indicaSon with
relevant pharmaceuScal companies
Op=mised formula=on for the stabilisa=on
of the Ac=ve Principle Ingredients (API’s)
• Revenue generated through licensing

16. Roadmap
2014 2015 2016 2017 2018 2019 ...
IP
Services/Colabora=ons
Insulins
R&D
2002…
Vaccines
Monoclonal an=bodies & Epoe=ns
EMA
Toxicity
Tests
FDA &
IPEC

17. Summary
• ExtremoChem is a tech based start-up
• CommercialisaSon of new excipients – distribuSon of
biopharmaceuScals without the need of cold chain
• New stabilisers for improvement of
biopharmaceu=cal produc=on yields during
downstream processing
• Ac=ve and safe biopharmaceuScals all over the world
• Addresses a recognised unmet market need

18. Stable BiopharmaceuScals
for a healthy world!

19. Thank you for your
a]enSon!
Rita Ventura, rita.ventura@extremochem.com
Eva Lourenço, eva.lourenco@extremochem.com
Christopher Maycock, chris.maycock@extremochem.com
Pedro Vilarinho, pedro.vilarinho@cotec.pt
Filipe Aguiar, filipe.aguiar@infraventus.com