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Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
Horst Bruning Exxim Animage Stanford May409
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Horst Bruning Exxim Animage Stanford May409

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  • 1. EXXIM - all you need for cone beam tomography Dr. Horst Bruning CEO, Animage LLC and Exxim Computing Stanford School of Engineering May 4 2009
  • 2. European – Silicon Valley Entrepreneurship • What can we learn from European entrepreneurs (if anything)? • Personal story • Exxim and Animage • What’s European about it? • What is Silicon Valley specific?
  • 3. The Personal Story Background in Germany and Switzerland Studied Physics at Universities of Erlangen/Nurnberg and Freiburg/Germany
  • 4. The Personal Story -2 PhD work at CERN in Geneva, Switzerland: Charm quarks, neutral currents, PSI-particles 3.1 GeV/c Competition with SLAC and MIT/Brookhaven  Do something of fundamental importance
  • 5. Personal Story - 3 • SIEMENS Healthcare in Erlangen Germany • CT, Angiography, cross-modality work • VP Engineering • Head of Basic Research • Concept Intrapreneurship
  • 6. Personal Story - 4 Founding of Exxim Computing Corporation in 2002 (Extreme X-ray IMaging) – 3 people, 2 products: • COBRA software and • LIDO active pixel array for detectors
  • 7. Exxim. Our team
  • 8. Calculates tomographic slices from a set of 2-D projection images: Cone Beam Tomography COBRA supports a wide spectrum of scanner hardware configurations
  • 9. Clockwise: transaxial slice, surface rendered insect, sagittal cut into volume rendered head image
  • 10. Can be setup on a wide spectrum of computer hardware: laptops, desktops, desktops with powerful graphics cards (nVidia Geforce), and network (Cobra Cluster Solutions)
  • 11. Based on Feldkamp’s algorithm Raw (intensity values) projection Air raw (bright field) projection
  • 12. First step of Feldkamp’s algorithm: converting input data to attenuation projections + =
  • 13. Second step of Feldkamp’s algorithm: filtering attenuation projections
  • 14. Third step of Feldkamp’s algorithm: backprojecting and accumulation
  • 15. Incorporates correction algorithms making output images more accurate and visually pleasant: - post-reconstruction noise reduction, - metal artifact reduction, - water-level density auto-calibration Noise reduction when different factors applied
  • 16. Iterative metal artifact reduction (MAR) Important for dental applications
  • 17. water-level density auto-calibration
  • 18. Useful optional features: - DICOM output, - Arbitrary output volume size (cubes even bigger than 4096x4096x4096 can be reconstructed), - Output volume origin offset and volume flips, - Built-in geometry calibration utility, - Accepting input projections containing intensity or logged attenuation values
  • 19. Cobra performance Dual-core 3 GHz PC nVidia Geforce 285 GTX installed Windows 64-bit platform Input data Output Volume Reconstruction time 512x512 512x512x512 < 20 sec 512 projections 960x768 640x640x576 60 sec 600 projections 1024x1024 1024x1024x1024 180 sec 700 projections
  • 20. Cobra software architecture
  • 21. Cobra SDK Flexible and easy to integrate char company[] = "YourCompanyName"; char serialNumber[] = "YourLicense"; DWORD result = 0; // ************ Init ************ result = CobraDispatcher_Init(company, serialNumber); result = CobraDispatcher_Communicate(); result = CobraDispatcher_SetReconMode( BPMODETAG_CONEBEAM | MODE_OFFLINE); // ************ Set parameters from file ************ CobraDispatcher_SetParametersByFile(cParFileName); // ************ Reconstruct ************ result = CobraDispatcher_TerminateReconstruction(); result = CobraDispatcher_ResetReconstruction(); result = CobraDispatcher_StartReconstruction();
  • 22. Version 7. New look. Built-in visualization
  • 23. Version 7. Scan database. Full DICOM interface
  • 24. Exxim is dedicated to continuous improvement of Volume CT software - Increase performance - Add functionality - Mitigate artifacts - Open for the future
  • 25. Founding of Animage, LLC in 1/2008 Serves the veterinary radiology market with a multi-modality x-ray imager – Volume CT – Digital Radiography – Digital Fluoroscopy
  • 26. Conclusions • Personal goals • Deep expertise in at least one field • Sufficient knowledge of all other fields of the corporate world • Access to venture capital questionable • A bit of luck

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