EXXIM - all you need for cone beam tomography




             Dr. Horst Bruning
   CEO, Animage LLC and Exxim Computing

...
European – Silicon Valley
        Entrepreneurship
• What can we learn from European
  entrepreneurs (if anything)?
• Pers...
The Personal Story
Background in Germany and Switzerland
Studied Physics at Universities of Erlangen/Nurnberg and
   Freib...
The Personal Story -2
PhD work at CERN in Geneva, Switzerland:
Charm quarks, neutral currents, PSI-particles 3.1 GeV/c
Com...
Personal Story - 3
•   SIEMENS Healthcare in Erlangen Germany
•   CT, Angiography, cross-modality work
•   VP Engineering
...
Personal Story - 4
Founding of Exxim Computing Corporation
 in 2002 (Extreme X-ray IMaging)
  – 3 people, 2 products:
    ...
Exxim. Our team
Calculates tomographic slices from a set of 2-D projection
images: Cone Beam Tomography

COBRA supports a wide spectrum of...
Clockwise: transaxial slice, surface
 rendered insect, sagittal cut into
   volume rendered head image
Can be setup on a wide spectrum of computer hardware:
laptops, desktops, desktops with powerful graphics cards (nVidia
   ...
Based on Feldkamp’s algorithm




                                                 Raw (intensity values)
                ...
First step of Feldkamp’s algorithm: converting
          input data to attenuation projections




+


=
Second step of Feldkamp’s algorithm:
   filtering attenuation projections
Third step of Feldkamp’s algorithm:
 backprojecting and accumulation
Incorporates correction
   algorithms making
  output images more
 accurate and visually
       pleasant:

- post-reconstr...
Iterative metal artifact reduction (MAR)




Important for dental
   applications
water-level density auto-calibration
Useful optional features:

- DICOM output,

 - Arbitrary output volume size (cubes even bigger
than 4096x4096x4096 can be ...
Cobra performance

                            Dual-core 3 GHz PC
                     nVidia Geforce 285 GTX installed
  ...
Cobra software architecture
Cobra SDK
                                     Flexible and easy to integrate

char company[]           = "YourCompanyName...
Version 7. New look. Built-in visualization
Version 7.
Scan database. Full DICOM interface
Exxim is dedicated to continuous
improvement of Volume CT software

- Increase performance

- Add functionality

- Mitigat...
Founding of Animage, LLC in 1/2008
Serves the veterinary radiology market with a
multi-modality x-ray imager

    – Volume...
Conclusions
• Personal goals
• Deep expertise in at least one field
• Sufficient knowledge of all other fields of
  the co...
Horst Bruning Exxim Animage Stanford May409
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Horst Bruning Exxim Animage Stanford May409

  1. 1. EXXIM - all you need for cone beam tomography Dr. Horst Bruning CEO, Animage LLC and Exxim Computing Stanford School of Engineering May 4 2009
  2. 2. European – Silicon Valley Entrepreneurship • What can we learn from European entrepreneurs (if anything)? • Personal story • Exxim and Animage • What’s European about it? • What is Silicon Valley specific?
  3. 3. The Personal Story Background in Germany and Switzerland Studied Physics at Universities of Erlangen/Nurnberg and Freiburg/Germany
  4. 4. The Personal Story -2 PhD work at CERN in Geneva, Switzerland: Charm quarks, neutral currents, PSI-particles 3.1 GeV/c Competition with SLAC and MIT/Brookhaven  Do something of fundamental importance
  5. 5. Personal Story - 3 • SIEMENS Healthcare in Erlangen Germany • CT, Angiography, cross-modality work • VP Engineering • Head of Basic Research • Concept Intrapreneurship
  6. 6. Personal Story - 4 Founding of Exxim Computing Corporation in 2002 (Extreme X-ray IMaging) – 3 people, 2 products: • COBRA software and • LIDO active pixel array for detectors
  7. 7. Exxim. Our team
  8. 8. Calculates tomographic slices from a set of 2-D projection images: Cone Beam Tomography COBRA supports a wide spectrum of scanner hardware configurations
  9. 9. Clockwise: transaxial slice, surface rendered insect, sagittal cut into volume rendered head image
  10. 10. Can be setup on a wide spectrum of computer hardware: laptops, desktops, desktops with powerful graphics cards (nVidia Geforce), and network (Cobra Cluster Solutions)
  11. 11. Based on Feldkamp’s algorithm Raw (intensity values) projection Air raw (bright field) projection
  12. 12. First step of Feldkamp’s algorithm: converting input data to attenuation projections + =
  13. 13. Second step of Feldkamp’s algorithm: filtering attenuation projections
  14. 14. Third step of Feldkamp’s algorithm: backprojecting and accumulation
  15. 15. Incorporates correction algorithms making output images more accurate and visually pleasant: - post-reconstruction noise reduction, - metal artifact reduction, - water-level density auto-calibration Noise reduction when different factors applied
  16. 16. Iterative metal artifact reduction (MAR) Important for dental applications
  17. 17. water-level density auto-calibration
  18. 18. Useful optional features: - DICOM output, - Arbitrary output volume size (cubes even bigger than 4096x4096x4096 can be reconstructed), - Output volume origin offset and volume flips, - Built-in geometry calibration utility, - Accepting input projections containing intensity or logged attenuation values
  19. 19. Cobra performance Dual-core 3 GHz PC nVidia Geforce 285 GTX installed Windows 64-bit platform Input data Output Volume Reconstruction time 512x512 512x512x512 < 20 sec 512 projections 960x768 640x640x576 60 sec 600 projections 1024x1024 1024x1024x1024 180 sec 700 projections
  20. 20. Cobra software architecture
  21. 21. Cobra SDK Flexible and easy to integrate char company[] = "YourCompanyName"; char serialNumber[] = "YourLicense"; DWORD result = 0; // ************ Init ************ result = CobraDispatcher_Init(company, serialNumber); result = CobraDispatcher_Communicate(); result = CobraDispatcher_SetReconMode( BPMODETAG_CONEBEAM | MODE_OFFLINE); // ************ Set parameters from file ************ CobraDispatcher_SetParametersByFile(cParFileName); // ************ Reconstruct ************ result = CobraDispatcher_TerminateReconstruction(); result = CobraDispatcher_ResetReconstruction(); result = CobraDispatcher_StartReconstruction();
  22. 22. Version 7. New look. Built-in visualization
  23. 23. Version 7. Scan database. Full DICOM interface
  24. 24. Exxim is dedicated to continuous improvement of Volume CT software - Increase performance - Add functionality - Mitigate artifacts - Open for the future
  25. 25. Founding of Animage, LLC in 1/2008 Serves the veterinary radiology market with a multi-modality x-ray imager – Volume CT – Digital Radiography – Digital Fluoroscopy
  26. 26. Conclusions • Personal goals • Deep expertise in at least one field • Sufficient knowledge of all other fields of the corporate world • Access to venture capital questionable • A bit of luck

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