This document discusses the connections between the pulp and periodontium, including through dentinal tubules, lateral canals, and apical foramina. It describes how pulpal disease and endodontic procedures can affect the periodontium, and vice versa, how periodontal disease and procedures can potentially impact the pulp. The document outlines various clinical diagnostic procedures and definitions. It then summarizes different clinical situations involving potential perio-endo lesions, including acute lesions, typical periodontal lesions, radiolucent lesions, lesions with sinus tract probing, and true combined perio-endo lesions.