Integration of Nanobots Into Neural Circuits As a Future Therapy for Neurodegenerative Disorders

1. Integration of Nanobots Into Neural Circuits As a
Future Therapy for Neurodegenerative Disorders
Presented By:
YUSUF ASAD

2. • Recent neuroscientific research indicates
that human brain altered by technological
devices.
• BMI for the :-
1. Neuroprosthetics for movement and
speech (Ipsihand).
2. Visual tactile and VR.
3. Genome editing Protien delivery (GFP-Cre) .
Introduction

3. • Nanotechnology for Neurodegenerative disorders -
Parkinson’s, Alzheimer’s disease.
• Neurosurgical mechanistic approach is not feasible.
1. cognitive & neural network function.
2. Chronic electrode degradation.
3. Microglial activated inflammation and scarring.
4. Rupture BBB.

4. Idea of a “endomyccorhizae-like interface” (ELI)
• Mechanism similar to endomyccorhizae form
of plant symbiosis.
• ELI designed to form webs, which connects
multiple neurons.
• Sense action potentials and deliver to
neurons.
• Compensate neuronal loss in
neurodegenerative disorders.

5. How ELI works ?
• seeks the perikarya of neuron
• action potential at tip of nanobots
• cation chamber mimics the natural
sodium channels
• electrical signal propogates to end of
neuron

6. Delivery of ELI into Brain Tissue
• ELI can be introduced directly into cerebrospinal fluid via piercing
~1mm into the subarachnoid space.
• ELIs would require their energy supply from thermal energy or fluid
flow, electrolytes in neurons or glial cells.
• ELI move in CSF to its destined neuronal site possibly with use of
propellers.
• Outside probe used to shut down any ELI that is not in a required
area.

7. Immune response
• Researchers used cationic coating to suppress immune response.
• Evidence that poly (b-amino alcohols) have the ability to weaken the
response to foreign bodies.
• Researchers suggest that zwitter ionic hydrogels, can inhibit encapsulation
and immune response to the foreign body.

8. Representative references
• Aflalo T, Kellis S, Klaes C, Lee B, Shi, Y, Pejsa K, et al. (2015). Decoding motor
imagery from the posterior parietal cortex of a tetraplegic human. Science. 348,
906–910. doi: 10.1126/science.aaa5417.
• Hebert LE, Scherr PA, Bienias JL, Bennett DA, and Evans DA (2003). Alzheimer
disease in the US population. Arch. Neurol. 60:1119. doi:
10.1001/archneur.60.8.1119.
• Brundrett MC (2002). Coevolution of roots and mycorrhizas of land plants. New
Phytol. 154, 275–304. doi: 10.1046/j.1469-8137.2002.00397.x
• Shih, J. J., Krusienski, D. J., andWolpaw, J. R. (2012). Brain-computer interfaces
in medicine. Mayo Clin. Proc. 87, 268–279. doi: 10.1016/j.mayocp.2011.12.008.
• Zhang L, Cao Z, Bai T, Carr L, Ella-Menye JR, Irvin C, et al. (2013). Zwitterionic
hydrogels implanted in mice resist the foreign-body reaction. Nat. Biotechnol. 31,
553–556. doi: 10.1038/nbt.2580
• Veiseh O, Doloff JC, Ma M, Vegas AJ, Tam HH, Bader AR, et al. (2015). Size-
and shape-dependent foreign body immune response to materials implanted in
rodents and non-human primates. Nat. Mater. 14, 643–651. doi:
10.1038/nmat4290

9. Thank you