A brief ppt on histoplasmosis

1. Raja Md
-RAJA MD
MICROBIOLOGY

2. CASE
STUDY Name : Emily
Age : 43
CHIEF COMPLAIN
• Fever
• Chronic Cough
• Chest Pain
• Rashes on shins
MEDICAL HISTORY
• HIV Positive
HISTORY
• Exploring Caves
• Renovate an abandoned poultry farm

3. CASE
STUDY
Erythema nodosum Hilar lymphadenopathy
BIOPSY CHEST X-RAY

4. CASE
STUDY
Yeasts like structure inside
neutrophils
CULTURE
BLOOD SMEAR
6 weeks
25-30° c
Antibody test – Negative
Antigen test – positive

5. Which one of the following do you think is
most likely the diagnosis?
i. Coccidioidomycosis
ii. Pulmonary aspergillosis
iii. Histoplasmosis
iv. Blastomycosis
v. Pulmonary aspergillosis

6. DIAGNOSTIC RESULT
Antigen test was being positive for Histoplasma Capsulatum
HISTOPLASMOSIS
● Histoplasma Capsulatum
pulmonary and disseminated infections
● Histoplasma Duboisii
skin and bone lesions

7. Yeast form
• 37°
• Body
Mold form
• 23-30°
• environment
THERMALLY DIMORPHIC

8. EPIDEMIOLOGY

9. PATHOGENESIS

10. CLINICAL MANIFESTATIONS
DISSEMINATED
HISTOPASMOSIS
MEDIASTINAL
GRANULOMA
FIBROSIS
ADENOPATHY
RARE
OCULAR
HISTOPLASMOSIS
MENINGITIS
PULMONARY
HISTOPLASMOSSIS
ACUTE SUB-ACUTE CHRONIC

11. DIAGNOSTIC TESTS

12. TREATMENT
Recover without therapy
Itraconazole
Amphotericin B

13. REFERENCES
https://www.jacmjournal.org/article.asp?issn=0972-
1282;year=2014;volume=16;issue=2;spage=70;epage=76;aulast=Remadevi
https://www.researchgate.net/publication/320086099_Disseminated_histoplasmosis_case_report_and_rev
iew_of_the_literature
https://www.semanticscholar.org/paper/Pulmonary-Histoplasmosis-in-a-patient-with-Cough%2C-
Britto/118936da7e7556cc4510c29f42755e05d5cb5656
https://www.sciencedirect.com/topics/medicine-and-dentistry/bilateral-hilar-lymphadenopathy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442517/

14. THANK YOU