Women are at much higher risk of sustaining season-ending knee injuries like ACL tears compared to men due to a combination of anatomical and athletic risk factors. Anatomically, women more often have risk factors like valgus alignment, joint laxity, narrow ACL notches, and smaller ACLs relative to their size. Athletically, women tend to land with straighter legs and increased dynamic valgus, placing greater stress on the ACL. This combination of risks leads to women having 2-8 times higher rates of ACL injuries in cutting, jumping and twisting sports compared to men. Prevention strategies focus on improving landing mechanics to reduce valgus moments and straight leg impacts.