Why is the epidermis called \"dynamic\"? Solution Answer: The outermost layer of the skin is called the epidermis and is a semi-permeable barrier consisting of anuclear cells. Cells of the epidermis may either adhere to each other (cell-cell adhesion) or to extracellular matrix (ECM, cell stratum adhesion). The epidermis is called dynamic (both with respect to structure and function) because: (1) Keratinocytes are tightly packed to provide protection and support from daily wear and tear. So, these cells are replaced almost at regular intervals (28 days). New keratinocytes from the basal layer migrate upwards and get increasingly keratinized as they move towards the skin surface. (2) Melanocytes in the basal layer provide protection against UV rays. (3) Immune cells within the epidermis recognize and fight against small molecules penetrating the skin. (4) The epidermis communicates with the dermis through the basal membrane zone..