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What is cost effectiveness? 
• There are infinite demands on our NHS, but a limited pot of money 
• Cost effectiveness analysis is a tool to help decide which interventions 
offer the best value for money and should be made available on the NHS 
• In theory, interventions that are low cost, but have high benefits in terms 
of health gains take priority over those with high costs and low health gains 
Costs 
• NHS costs of the 
health intervention 
minus the NHS costs 
saved by the 
intervention 
• Measured in £ 
Benefits 
• Health benefits gained 
by preventing /treating 
the health problem 
• Measured in quality of 
life years (QALYs) 
• 1 QALY = 1 year at full 
health 
*NHS costs also include personal social services costs
The cost effectiveness threshold 
• The NHS is currently valued at £20,000/QALY 
• All new interventions should cost £20,000/QALY or less, otherwise the 
NHS becomes less efficient (we end up spending more money on a given 
amount of health) 
Years of life saved 
PLUS 
Quality of life saved from 
preventing disease 
Vaccination costs 
MINUS 
Cost savings to NHS and 
social services from 
preventing disease 
The cost effectiveness assessment of Bexsero on which the JCVI based their 
interim statement gave a result which was considerably higher than £20,000 so 
they could not recommend the vaccine for routine use
Was the JCVI interim opinion correct? 
• A cost effectiveness model is a simplification 
of reality 
• The answer you get depends on the 
parameters that you feed into the model 
• MRF argued that the parameters 
underpinning the burden of meningococcal 
disease were undervalued

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What is cost effectiveness

  • 1. What is cost effectiveness? • There are infinite demands on our NHS, but a limited pot of money • Cost effectiveness analysis is a tool to help decide which interventions offer the best value for money and should be made available on the NHS • In theory, interventions that are low cost, but have high benefits in terms of health gains take priority over those with high costs and low health gains Costs • NHS costs of the health intervention minus the NHS costs saved by the intervention • Measured in £ Benefits • Health benefits gained by preventing /treating the health problem • Measured in quality of life years (QALYs) • 1 QALY = 1 year at full health *NHS costs also include personal social services costs
  • 2. The cost effectiveness threshold • The NHS is currently valued at £20,000/QALY • All new interventions should cost £20,000/QALY or less, otherwise the NHS becomes less efficient (we end up spending more money on a given amount of health) Years of life saved PLUS Quality of life saved from preventing disease Vaccination costs MINUS Cost savings to NHS and social services from preventing disease The cost effectiveness assessment of Bexsero on which the JCVI based their interim statement gave a result which was considerably higher than £20,000 so they could not recommend the vaccine for routine use
  • 3. Was the JCVI interim opinion correct? • A cost effectiveness model is a simplification of reality • The answer you get depends on the parameters that you feed into the model • MRF argued that the parameters underpinning the burden of meningococcal disease were undervalued