Excess amyloid β-peptide is believed to be a main contributor to the dysfunction and degeneration of neurons that occurs in Alzheimer’s disease. Aβ is a 38 to 43 amino acid peptide that is derived from the β amyloid precursor protein, APP.

1. CD Creative Diagnostics
®
CD Creative Diagnostics
®
APP Processing and
Plaque Formation

2. CD Creative Diagnostics
®
CD Creative Diagnostics
®
APP
Aβ
Aβ Plaque
Neuronal dysfunction
& degeneration
Alzheimer’s disease

3. CD Creative Diagnostics
®
CD Creative Diagnostics
®
APLP1APLP2APP
TM domain
N-terminal
C-terminal
Aβ
APP superfamily protein family

4. CD Creative Diagnostics
®
CD Creative Diagnostics
®
90%
10%
APP processing
Amyloidogenic Pathway
Amyloid Plaque Formation
Canonical Pathway
Non-amyloidogenic
APPCleared

5. CD Creative Diagnostics
®
CD Creative Diagnostics
®
The non-amyloidogenic pathway
APPC83CTF
P3
sAPPα
γ-secretase
α-secretase
Aβ

6. CD Creative Diagnostics
®
CD Creative Diagnostics
®
The Amyloidogenic Pathway
APP C99 AICD
sAPPβ
γ-secretase
β-secretase
Aβ
Aβ

7. CD Creative Diagnostics
®
CD Creative Diagnostics
®
The Amyloidogenic Pathway
Endosom
e
Aβ
Aβ Plaque
Aβ oligomer

8. CD Creative Diagnostics
®
CD Creative Diagnostics
®
Aβ 1-42
Structure of Aβ1-40
Structure of
Aβ1-42
VS.

9. CD Creative Diagnostics
®
CD Creative Diagnostics
®
www.creative-diagnostics.com
45-1 Ramsey Road, Shirley, NY 11967, USA
info@creative-diagnostics.com
APP processing │