This document provides an overview of the new VP.org website and its goals of promoting research on vulnerable plaque (VP). Key points: 1) The website will include an online library called "Atheroline" with medical literature and multimedia about atherosclerosis and VP. 2) A toolbar will provide one-click access to VP-related information resources. 3) Members can customize "Personal VP Watch" alerts on new science, patents, and industry news. 4) An upcoming VP symposium is announced to bring together researchers and industry. The overall aim is to accelerate VP detection and treatment to ultimately eradicate heart attacks.

1. www.VP.org

4. The New VP.org

5. Why VP.org?

6. Research = Re-Search!
• 1) Search for prior observations.
• 2) Make new observation.

15. Olcott 1931 “plaque rupture”
Leary 1934 “rupture of atheromatous abscess”
Wartman 1938 “rupture-induced occlusion”
Horn 1940 “plaque fissure”
Helpern 1957 “plaque erosion”
Crawford 1961 “plaque thrombosis”
Gore 1963 “plaque ulceration”
Friedman 1964 “macrophage accumulation”
Byers 1964 “thrombogenic gruel”
Chapman 1966 “plaque rupture”
Plaque Fissure in Human Coronary Thrombosis (Abstract) Fed. Proc. 1964, 23, 443
Constantinidis P.
“The destruction of the hyalinized wall separating lumen
from the atheroma was almost always observed to be
preceded by or associated with its invasion by lipid
containing macrophages.”
Friedman and van den Bovenkamp 1965

16. Recycling of Science and
Missed Opportunities to Save Lives
• If plaque rupture was broadly communicated between all investigators and
clinicians involved in the field of cardiovascular disease, in other words, if
cardiovascular pathologists, clinicians, and biologists in 1960s perhaps:
– Thermal detection could have been in clinical trial in 1970s. We could
not have OCT which needs fast computer processing but NIR
spectroscopy could have been a possibility as they were screening lean
meet from fat in food industry in 1970s
– Plaque immunology could have been fully investigated by 1980 and
specific immune markers of plaque inflammation might have been
available as a cheap bedside test to all primary care physicians in 2001.
– …
– Millions of lives including our grand parents and parents, friends
and relatives could have been saved to enjoy a few more years
with their families...

17. Internet
• No need to talk about.
Visit:
EverythingYouWant.Com!

18. Re-Search @ the Speed of Light
Mort Gates!!!

19. What’s new in VP.org?
• Medical Professional (VP Community and others)
• Industry
• Media
• Consumers (patients and their relatives) ACC 2002
• VP Biology and Pathology
• VP Detection
• VP Treatment

20. What’s new in VP.org?
• “Atheroline”; A new online library
powered by: Medline, Science Citation
Index, patent data bases (United States,
and PCT), multimedia presentations,
conference abstracts, and regular update
of clinical trials along with many novel
interactive features, all dedicated to the
field of Atherosclerosis and investigators
in the field of vulnerable plaque.

21. What’s new in VP.org?
• “Atheroline Toolbar” a truly one-click-
away option to the whole world of medical
literature and online information related to
atherosclerosis and vulnerable plaque

24. What’s new in VP.org?
• “Personal VP Watch” members of VP.org
can program their own VP Watch to
receive individualized VPW (science,
patents, industry…) on any periodical
basis, daily, twice a week, weekly, bi-
weekly…

25. Dear VP Scientist and Industry:
Rest assured and sleep well as I am up 24 hr 7
days a week / 365 days watching VP for you.
Looking forward to seeing you at the VP Dinner
Symposium in Anaheim, California Monday
November 12, 7-10pm @ the Hilton Convention
Center.
May God bless your heart with no VP.
Sincerely yours!
VP Watch

26. The New VP.org is
coming up in 36 days.
COUNT DOWN!
8pm
Monday November 12th
– Vulnerable Plaque Dinner Symposium
The Hilton @ Convention Center
AHA 2001 Anaheim, California
Please tell your Palm Pilot

28. Mohammad Madjid, MD
Reza Mohammadi, MDParsa Mirhaji, M.D.
Mohammed Reza Khan, MD
Khawar Gul, M.D.

29. New Members of VP.org Team
• Eric Jarvis
• Alireza Zarrabi
• Cornelius Nwora
• Shayda Katousian
• Mark Johnson
• Marilyn Sanders

30. 2001 2050
Genomic
Proteomic
2010 2020 2030 2040
Celomic?
VP Treatment
Home-based VP
Screening Test
Heart Attack
Eradicated
US Annual MI
<50,000
Heart Cloning
VP Rx as OTC or
Vaccine?
Eradication of Heart Attack
VP Detection
Mission Impossible!

31. Association for Eradication of Heart Attack
www.VP.org
www.AEHA.org