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Vitamin a deficiency disorder /Complication
1. Xeropthalmia
2. Blindness
3. Conjunctival xerosis
4. Bitot’s spots
5. Corneal xerosis
6. Keratomalacia
1.XEROPTHALMIA
 An eye disease caused by vitamin A deficiency,
marked by dryness and ulceration of the conjunctiva
and cornea.
 If untreated, it may cause blindness.
 Etiology:
a. Dietary deficiency:
 Lack of food
 Lack of knowledge
 Low socioeconomic condition
 Faulty eating habit
b. Defective absorption:
 Chronic diarrhoea
 Malabsorption
 Inflammatory bowel syndrome
c. Increase utilization of vitamin A
 Pregnancy
 Growing age (6months- 6 yrs)
 Viral diseases e.g. measles
d. PEM & infection
WHO CLASSIFICATION :
i. XN : Night blindness
ii. X1A: Conjunctival xerosis
iii. X1B: Bitot’s spot
iv. X2: Corneal xerosis
v. X3A: Keratomalacia/ Corneal ulcer with ≤1/3
corneal involvement.
vi. X3B: Keratomalacia/ Corneal ulcer with ≥ 1/3
corneal involvement.
vii. XS: Corneal scar due to xerophthalmia.
viii.XF: Xerophthalmic fundus
Management:
i. Local ocular therapy: for conjunctival xerosis-
artificial tear drop.
ii. Vitamin A therapy:
 Above the age of 1 year 2 lakh IU of vitamin
A/oral 6 monthly.
 6 months to 1yrs (<8 kg) 1 lakh IU of vit. A /oral
6 monthly.
 Less than 6months 50,000 IU of vit. A 1st,2nd
days and 2 weeks.
iii. Treatment of underlying condition :
 PEM & other nutritional disorders infection.
 Diarrhoea, parasitic condition.
iv. Prophylaxis:
 Routine supplement of vit. A according to
national schedule.
 Public awareness
 Increase the intake of vit. A containing food.
 Routine vaccination (e.g. Measles)
2. Blindness
 Best corrected ‘visual acuity of less than 3/60
(snellen’s) or its equivalent’ or inability to count
finger in day light at a distance of 3 meters.
Causes:
 Cataract
 Trachoma
 Glaucoma
 Xerophthalmia
 Trauma/ injury
 Corneal opacity
 others
CONJUNCTIVAL XEROSIS
BITOT’S SPOTS
CORNEAL XEROSIS
KERATOMALACIA

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Vitamin a deficiency disorder

  • 1. Vitamin a deficiency disorder /Complication 1. Xeropthalmia 2. Blindness 3. Conjunctival xerosis 4. Bitot’s spots 5. Corneal xerosis 6. Keratomalacia
  • 2. 1.XEROPTHALMIA  An eye disease caused by vitamin A deficiency, marked by dryness and ulceration of the conjunctiva and cornea.  If untreated, it may cause blindness.  Etiology: a. Dietary deficiency:  Lack of food  Lack of knowledge  Low socioeconomic condition  Faulty eating habit
  • 3. b. Defective absorption:  Chronic diarrhoea  Malabsorption  Inflammatory bowel syndrome c. Increase utilization of vitamin A  Pregnancy  Growing age (6months- 6 yrs)  Viral diseases e.g. measles d. PEM & infection
  • 4. WHO CLASSIFICATION : i. XN : Night blindness ii. X1A: Conjunctival xerosis iii. X1B: Bitot’s spot iv. X2: Corneal xerosis v. X3A: Keratomalacia/ Corneal ulcer with ≤1/3 corneal involvement. vi. X3B: Keratomalacia/ Corneal ulcer with ≥ 1/3 corneal involvement. vii. XS: Corneal scar due to xerophthalmia. viii.XF: Xerophthalmic fundus
  • 5. Management: i. Local ocular therapy: for conjunctival xerosis- artificial tear drop. ii. Vitamin A therapy:  Above the age of 1 year 2 lakh IU of vitamin A/oral 6 monthly.  6 months to 1yrs (<8 kg) 1 lakh IU of vit. A /oral 6 monthly.  Less than 6months 50,000 IU of vit. A 1st,2nd days and 2 weeks.
  • 6. iii. Treatment of underlying condition :  PEM & other nutritional disorders infection.  Diarrhoea, parasitic condition. iv. Prophylaxis:  Routine supplement of vit. A according to national schedule.  Public awareness  Increase the intake of vit. A containing food.  Routine vaccination (e.g. Measles)
  • 7. 2. Blindness  Best corrected ‘visual acuity of less than 3/60 (snellen’s) or its equivalent’ or inability to count finger in day light at a distance of 3 meters. Causes:  Cataract  Trachoma  Glaucoma  Xerophthalmia  Trauma/ injury  Corneal opacity  others