Caused by Rhabdoviridae family, Vesiculovirus. Development of vesicles on the mouth and feet. The virus, an arbovirus, is spread to cattle, horses, and pigs primarily by sandflies and blackflies. The mechanism of injury in vesicular stomatitis is cell dysfunction and lysis leading to intercellular edema with vesiculation, erosion, and ulceration of mucosae and skin. Pathogenesis of the disease is by the bite of the flies, entry of virus, viral replication in the cell and rupture of the cell, which form intercellular space that is fluid filled to form vesicles. Rupture of this vesicles leads to erosion/ulceration of overlying mucosa or skin.