This presentation is made to act as a guide and a short reminder to clinicians and medical students on Volkmann's Ischaemic Contracture, which is a medical condition that can lead to activities limitation and public participation restriction. This presentation explore aspects of the condition such as what it is, causes, how it can be diagnosed, how it can be managed and others.
This presentation is made to act as a guide and a short reminder to clinicians and medical students on Volkmann's Ischaemic Contracture, which is a medical condition that can lead to activities limitation and public participation restriction. This presentation explore aspects of the condition such as what it is, causes, how it can be diagnosed, how it can be managed and others.
ANKLE FRACTURES
Pott’s fracture
A Pott’s fracture is a type of ankle fracture that is characterized by a break in one or more bony prominences on the sides of the ankle known as the malleoli.
Also known as Broken Ankle, Ankle Fracture and malleolar fracture.
Pott’s fracture often occurs in combination with other injuries such as a sprained ankle or other fractures of the foot, ankle or lower leg.
ANKLE FRACTURES
Pott’s fracture
A Pott’s fracture is a type of ankle fracture that is characterized by a break in one or more bony prominences on the sides of the ankle known as the malleoli.
Also known as Broken Ankle, Ankle Fracture and malleolar fracture.
Pott’s fracture often occurs in combination with other injuries such as a sprained ankle or other fractures of the foot, ankle or lower leg.
1.Anatomy
a.Course
b.Motor distribution
c.Sensory distribution
2.Common sites affected
3.Level of median nerve injury
4.Clinical feature with various test performed
5.Various syndromes related to median nerve
6.Treatment
7.Summary
After completion of this session, students should be able to discuss, identify, and describe:
The anatomical factors predisposing to nerve injuries.
The anatomy of deformity, weakness and sensory loss following the nerve injury.
The applied anatomy of clinical examination for specific nerves.
Surgical anatomy of treating nerve injuries.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
2. VOLKMANN’S ISCHEMIC CONTRACTURE
• Definition :A condition which is characterized
by ischemic necrosis of the structures contained
within the volar compartment of the forearm
associated with crippling contractures and varying
degrees of neurologic deficit.
3. • HISTORY
• 1881, Volkmann stated
that paralytic
contractures that
develop within a few
hours after injury are
caused by arterial
insufficiency or ischemia
of muscles.
4. • HISTORY
• 1906,Hildebrand first used the term
"Volkmann ischemic contracture“ to describe the final
result of any untreated compartment syndrome.
• 1909, Thomas found that paralytic contractures
followed severe contusions of the forearm without
fractures.
• 1914, Murphy reported that increased internal
pressures in the deep compartments of the forearm
and effusion in the muscles resulted in ischemia.
6. • Volkmann’s ischemic
contracture is a late
sequelae of untreated
or inadequately
treated compartment
syndrome in which
necrotic muscle and
nerve tissue are
replaced with fibrous
tissue .
7. ANATOMY
• At the entrance to the
flexor compartment of
the forearm , lacertus
fibrosus fans medially
from the biceps tendon.
• Beneath the lacertus
fibrosus the brachial
artery and median
nerve pass to enter the
flexor compartment.
8. ANATOMY
• The brachial artery divides into
radialand ulnar arteries.
• The radial artery courses
superficially and is not crossed by
any structure in the forearm.
• The ulnar artery passes beneath
the pronator teres where it gives
a branch, the common
interosseus artery.
• The common interosseus artery
further divides into volar and
dosal interosseus arteries.
9. ANATOMY
• The median nerve
accompanies the brachial
artery beneath the
lacertus fibrosus and
enters the substance
of the pronator teres
passing between its
humeral and ulnar heads.
10. ANATOMY
• Compartments of the
forearm.
• 1. Superficial
volar compartment.
• 2. Deep volar
compartment.
• 3. Dorsal compartment.
• 4. Mobile wad of Henry.
11. ETIOLOGY
• Supracondylar
fractures of the
humerus in children is
the most common
precipitating injury.
• The brachial artery may
get impinged on the
sharp proximal
fragment against which
it is held by lacertus
fibrosus.
15. TOLERANCE OF TISSUE
• 1. Muscle :-
• Functional impairment after
2-4 hours of ischemia.
• Irreversible functional loss
after 4-12 hours.
• 2. Nerves :-
• Functional impairment after
30 mins of ischemia.
• Irreversible function loss
after 12-24 hrs.
16. CLINICAL PICTURE
• Acute compartment syndrome
(Impending Volkmann’s
ischemic contracture)
• 1. If local compression is the
cause :
• Pulses intact ( in early stages)
• Paresis
• Stretch pain
• Parasthesia (median nerve
sensory zone commonly)
• Good capillary filling.
18. CLINICAL PICTURE
• Two point
discrimination is more
than 1 cm in in the
sensory zone of the
median nerve.
• Diminished perception
of vibratory sense of
256cycles/sec
stimulus.
20. CLINICAL PICTURE
• Evaluating the intracompartmental pressure.
• Range between 10 ± 20 mmHg below the
diastolic pressure - cessation of blood flow is
eminent.
• 40± 50 mmHg - muscle threatening compression
and ischemia are present.
• Pressure of 30 mmHg or greater - criterion
for fasciotomy.
21. Deformities in Volkmann’s ischemic
contracture
• Mild type :
• Deep flexors are partially
involved particularly,
Flexor digitorum profundus.
• Flexion contractures of one
or more fingers which can be
extended on hyperflexing
the wrist.
• Resistant pronation
contracture involving either
the pronator teres or
pronator quadratus.
22. Deformities in Volkmann’s ischemic
contracture
• Moderate type :
• Involves most of the
flexor digitorum profundus,
flexor pollicis longus and part
of flexor digitorum superficialis.
• Neurological deficit involving
median nerve more than
ulnar nerve is present.
• Deformity is intrinsic minus
hand.
• Diminished sensations in
median and ulnar nerve zones.
23. Deformities in Volkmann’s ischemic
contracture
• Severe type :
• All the flexor muscles are
involved.
• Neurological deficit is
severe.
• Joint contractures are
marked.
• Wasting of forearm
muscles .
25. MANAGEMENT - ACUTE COMPARTMENT
SYNDROME (IMPENDING VIC)
• Forearm fasciotomy
• Incision :A volar
curvilinear liberal
incision medial to the
biceps tendon, crossing
the elbow flexion
crease at an angle
carring it distally to the
palm to release the
carpal tunnel.
26. MANAGEMENT - ACUTE COMPARTMENT
SYNDROME (IMPENDING VIC)
• Exploration must extend deeply
to the FDPand FPL.
• Necrotic muscle tissue is excised.
• Median nerve freed beneath the
lacertus fibrosus.
• Ulnar nerve is freed and
transplanted anteriorly .
• Brachial artery must be inspected
and decompressed .
• Surgical wound is left open
for secondary closure later when
swelling subsibes.
• Extremity supported with splint in
funtional position.
27. CONSERVATIVE MANAGEMENT
ESTABLISED DEFORMITIES
• Robert Jones
method(1930s).(1930s).
• Wooden tongue
depressors were used to
correct established
deformities gradually
from distal to proximal
over a prolonged period
of time .
28. CONSERVATIVE MANAGEMENT
ESTABLISED DEFORMITIES
• Banjo splint :
• Banjo splint used
with rubber bands
fastened to adhesive
tape on the fingers
permits the fingers to
be exercised at all
times and is most
efficient.
30. INGLIS & COOPER
• Incision on the medial aspect of volar side of
the arm 5 cm proximal to medial
epicondyle and distally to midpoint of forearm
over the ulna.
31. INGLIS & COOPER
• Ulnar nerve is identified, released from the cubital tunnel and
protected.
• Tendinous origins of muscles on the medial epicondyle are cut.
• Flexor carpi ulnaris and Flexor digitorum profundus are completely
released from the medial epicondyle and ulna.
32. INGLIS & COOPER
• Lacertus fibrosus is divided along with any
remaining portions of the flexor muscle origin.
• Ulnar nerve is trasposed anteriorly.
33. WILLIAMS & HADDAD
• Medial aspect of arm and forearm anterior to the medial
epicondyle of the humerus, beginning 5 cm proximal to the
elbow extending distally to 5cm proximal to the elbow
extending distally to 5cm proximal to the wrist.
34. WILLIAMS & HADDAD
• Structures anterior and medial to the elbow
are exposed.
35. WILLIAMS & HADDAD
• Lacertus fibrosus is divided.
• Origins of the superficial flexors are released from the
medial epicondyle.
• Origin of flexor digitorum superficialis is released from
radius.
36. WILLIAMS & HADDAD
• Origin of Flexor carpi ulnaris is released from
olecronon.
• Common origin of flexor carpi ulnaris and
flexor digitorum profundus are released from ulna.
37. WILLIAMS & HADDAD
• Origin of flexor digitorum profundus is
released from volar aspect of ulna and
interosseous membrane.
38. WILLIAMS & HADDAD
• Origin of flexor digitorum profundus to the
index finger is released from radius.
39. WILLIAMS & HADDAD
• Ulnar nerve is transplanted anteriorly into
brachialis muscle.
40. AFTER SURGERY
• Sutures are removed after 3 weeks.
• Extension hand splint should be worn for 3
months.
• Occupation and physiotherapy should be
continued until desirable function is attained.